Daniel Sessler

Prof. Daniel Sessler

Cleveland Clinic
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Research Focus & Metrics

Academic Career Length

36Years (1991-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 May 2019 in British Journal of Anaesthesia
Verified
Journal Article
Closed access
Daniel SesslerDaniel Sessler
Daniel Sessler
JBJoshua A. Bloomstone
Joshua A. Bloomstone
SASolomon Aronson
Solomon Aronson
CBColin Berry
Colin Berry
TGTong J. Gan
Tong J. Gan
MHMark Hamilton
Mark Hamilton

1 August 2008 in Anesthesiology
Verified
Journal Article
Open access
PDF file
Daniel SesslerDaniel Sessler
Daniel Sessler
Most clinically available thermometers accurately report the temperature of whatever tissue is being measured. The difficulty is that no reliably core-temperature-measuring sites are completely noninvasive and easy to use-especially in patients not undergoing general anesthesia. Nonetheless, temperature can be reliably measured in most patients. Body temperature should be measured in patients undergoing general anesthesia exceeding 30 min in duration and in patients undergoing major operations during neuraxial anesthesia. Core body temperature is normally tightly regulated. All general anesthetics produce a profound dose-dependent reduction in the core temperature, triggering cold defenses, including arteriovenous shunt vasoconstriction and shivering. Anesthetic-induced impairment of normal thermoregulatory control, with the resulting core-to-peripheral redistribution of body heat, is the primary cause of hypothermia in most patients. Neuraxial anesthesia also impairs thermoregulatory control, although to a lesser extent than does general anesthesia. Prolonged epidural analgesia is associated with hyperthermia whose cause remains unknown.

12 June 1997 in New England Journal of Medicine
Verified
Journal Article
Closed access
Daniel SesslerDaniel Sessler
Daniel Sessler
Mammals need to maintain a nearly constant internal temperature. If the internal temperature deviates substantially from normal, metabolic functions generally deteriorate. The human thermoregulatory system usually maintains a core body temperature near 37°C. Perioperative hypothermia, however, is common because of the inhibition of thermoregulation induced by anesthesia and the patient's exposure to a cool environment. Hypothermia leads to numerous complications, including coagulopathy, morbid cardiac events, and a decreased resistance to surgical-wound infection.Normal ThermoregulationThe processing of thermoregulatory information has three components: afferent thermal sensing, central regulation, and efferent responses. Together, they work to maintain the normal core body temperature. . . .

1 June 2016 in The Lancet
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Journal Article
Closed access
Daniel SesslerDaniel Sessler
Daniel Sessler

1 August 2001 in Anesthesiology
Verified
Journal Article
Closed access
Daniel SesslerDaniel Sessler
Daniel Sessler

1 December 1997 in Anesthesiology
Verified
Journal Article
Closed access
RLRainer Lenhardt
Rainer Lenhardt
EMElvine Marker
Elvine Marker
VGVeronika Goll
Veronika Goll
HTHeinz Tschernich
Heinz Tschernich
AKAndrea Kurz
Andrea Kurz
FLFranz Lackner
Franz Lackner
Background: Intraoperative hypothermia is common and persists for several hours after surgery. Hypothermia may prolong immediate recovery by augmenting anesthetic potency, delaying drug metabolism, producing hemodynamic instability, or depressing cognitive function. Accordingly, the authors tested the hypothesis that intraoperative hypothermia prolongs postoperative recovery. Methods: Patients undergoing elective major abdominal surgery (n = 150) were anesthetized with isoflurane, nitrous oxide, and fentanyl. They were randomly assigned to routine thermal management (hypothermia) or extra warming (normothermia). Postoperative surgical pain was treated with patient-controlled analgesia. Fitness for discharge from the postanesthesia care unit was evaluated at 20-min intervals by investigators blinded to group assignment and postoperative core temperatures. Scoring was based on a modification of a previously published system that included activity, ventilation, consciousness, and hemodynamic responses. Patients were considered fit for discharge when they sustained a score of 80% (13 points) for at least two consecutive measurement periods. Results: Morphometric characteristics and anesthetic management were similar in each group. Final intraoperative core temperatures differed by approximately 2 degrees C: 34.8 +/- 0.6 versus 36.7 +/- 0.6 degrees C (mean +/- SD, P < 0.001). Postoperative pain scores and postoperative use of patient-controlled opioid were similar. Hypothermic patients required approximately 40 min longer (94 +/- 65 vs. 53 +/- 36 min) to reach fitness for discharge, even when return to normothermia was not a criterion (P < 0.001). Duration of recovery in the two groups differed by approximately 90 min when a core temperature >36 degrees C was also required (P < 0.001). Conclusion: Maintaining core normothermia decreases the duration of postanesthetic recovery and may, therefore, reduce costs of care.