Mahejibin Khan

Dr. Mahejibin Khan

Microbiology & Fermentation Technology, Central Food Technological Research Institute, Mysore, Karnātaka, International
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Research Focus & Metrics

Academic Career Length

24Years (2003-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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13 August 2018 in Frontiers in Immunology
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Journal Article
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ETElden Berla Thangam
Elden Berla Thangam
EJEbenezer Angel Jemima
Ebenezer Angel Jemima
HSHimadri Singh
Himadri Singh
MBMirza Saqib Baig
Mirza Saqib Baig
MKMahejibin Khan
Mahejibin Khan
RSRohit Saluja
Rohit Saluja
Histamine and its receptors (H1R–H4R) play a crucial and significant role in the development of various allergic diseases. Mast cells are multifunctional bone marrow-derived tissue-dwelling cells that are the major producer of histamine in the body. H1R are expressed in many cells, including mast cells, and are involved in Type 1 hypersensitivity reactions. H2R are involved in Th1 lymphocyte cytokine production. H3R are mainly involved in blood–brain barrier function. H4R are highly expressed on mast cells where their stimulation exacerbates histamine and cytokine generation. Both H1R and H4R have important roles in the progression and modulation of histamine-mediated allergic diseases. Antihistamines that target H1R alone are not entirely effective in the treatment of acute pruritus, atopic dermatitis, allergic asthma, and other allergic diseases. However, antagonists that target H4R have shown promising effects in preclinical and clinical studies in the treatment of several allergic diseases. In the present review, we examine the accumulating evidence suggesting novel therapeutic approaches that explore both H1R and H4R as therapeutic targets for histamine-mediated allergic diseases.

1 January 2015 in Clinical and Translational Allergy
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Journal Article
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RSRohit Saluja
Rohit Saluja
MKMahejibin Khan
Mahejibin Khan
MCMartin K. Church
Martin K. Church
MMMarcus Maurer
Marcus Maurer
Interleukin‐33 (IL‐33) is a member of the interleukin‐1 (IL‐1) cytokine family. It is preferentially and constitutively expressed in different structural cells such as epithelial cells, endothelial cells, and smooth muscle cells. During necrosis of these cells (after tissue injury or cell damage), the IL‐33 that is released may be recognized by different types of immune cells, such as eosinophils, basophils and, especially, mast cells. IL‐33 needs the specific receptor ST2 (membrane‐bound receptor) and Interleukin‐1 receptor accessory protein heterodimer for its binding, which instigates the production of different types of cytokines and chemokines that have crucial roles in the exacerbation of allergic diseases and inflammation. IL‐33 and mast cells have been influentially associated to the pathophysiology of allergic diseases and inflammation. IL‐33 is a crucial regulator of mast cell functions and might be an attractive therapeutic target for the treatment of allergic and inflammatory diseases. In this review, we summarize the current knowledge regarding the roles of IL‐33 and mast cells in the pathogenesis of allergies and inflammation.

28 February 2013 in Annual Review of Food Science and Technology
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Journal Article
Closed access
MKMahejibin Khan
Mahejibin Khan
ENEkambaram Nakkeeran
Ekambaram Nakkeeran
SUSukumaran Umesh-Kumar
Sukumaran Umesh-Kumar
The understanding that enzymatic degradation of fruit pectin can clarify juices and improve juice yields resulted in the search for microbial pectinases and application in vegetable- and fruit-processing industries. Identified enzymes were classified on the basis of their catalytic activity to pectin or its derivatives and in terms of industrial use. Discovery of gene sequences that coded the enzymes, protein engineering, and molecular biology tools resulted in defined microbial strains that over-produced the enzymes for cost-effective technologies. Recent perspectives on the use of pectin and its derivatives as dietary fibers suggest enzymatic synthesis of the right oligomers from pectin for use in human nutrition. While summarizing the activities of pectin-degrading enzymes, their industrial applications, and gene sources, this review projects another application for pectinases, which is the use of enzymatically derived pectin moieties in functional food preparation.

13 October 2014 in Journal of Food Science
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Journal Article
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TST.A. Sathya
T.A. Sathya
MKMahejibin Khan
Mahejibin Khan

22 January 2020
Verified
Book Chapter
Open access
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TVThiraviam Vanitha
Thiraviam Vanitha
MKMahejibin Khan
Mahejibin Khan
Pectin is a branched heteropolysaccharide consisting of long-chain galacturonan segments and other neutral sugars such as rhamnose, arabinose, galactose, and xylose. It forms a matrix with celluloses and hemicelluloses and contributes to the cell structure. Due to the presence of several sugar moieties and different levels of methyl esterification, pectin does not have defined molecular weight like other polysaccharides. Pectin has wide applications. It is used as emulsifier, gelling agent, thickener, stabilizer, and fat or sugar replacer in low-calorie foods. Pectin and pectin-derived oligosaccharides can also be used as an important ingredient in functional foods. In recent past, a new application envisaged for pectin polymers as edible films or coating. These films act as natural barrier for exchange of moisture, gases, lipids, and volatiles between food and environment, and protect fruits and vegetable from microbial contamination. The degree of esterification of pectin and other structural modifications defines the functional properties. Herein, various functional properties of pectin in relation to food processing and packaging are discussed.

31 May 2017 in Journal of Nutritional Health & Food Engineering
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Journal Article
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MKMahejibin Khan
Mahejibin Khan
PSPragya Singh
Pragya Singh
HHHailu Hailemariam
Hailu Hailemariam
Hibiscus sabdariffa commonly named as "red sorrel" or "roselle" is a member of malvaceae family. It is a medicinal plant with a worldwide fame and has more than three hundred species which are distributed in tropical and subtropical regions around the world. Roselle can adapt to a variety of soil in a warmer and more humid climate. Roselle is rich in organic acids including citric, malic, tartaric and allo-hydroxycitric acids. The plant is also known for its Beta carotene, vitamin C, protein and total sugar. Roselle, having various medically important compounds called photochemical, is well known for its nutritional and medicinal properties. Many parts of Roselle including seeds, leaves, fruits and roots are used in various foods as well as in herbal medicine as a potential non-pharmacological treatment. Different extracts from Roselle plays a crucial role in treating different medical problems including many cardiovascular disorders, helmenthic disease and cancer. The plant also act as an anti oxidant and used in obesity management