Multidrug‐resistant (MDR) pathogens have created a fatal problem for human health and antimicrobial treatment. Among the currently available antibiotics, many are inactive against MDR pathogens. In this context, heterocyclic compounds/drugs play a vital role. Thus, it is very much essential to explore new research to combat the issue. Of the available nitrogen‐bearing heterocyclic compounds/drugs, pyridine derivatives are of special interest due to their solubility. Encouragingly, some of the newly synthesized pyridine compounds/drugs are found to inhibit multidrug‐resistant S. aureus (MRSA). Pyridine scaffold bearing poor basicity generally improves water solubility in pharmaceutically potential molecules and has led to the discovery of numerous broad‐spectrum therapeutic agents. Keeping these in mind, we have reviewed the chemistry, recent synthetic techniques, and bacterial preventative activity of pyridine derivatives since 2015. This will facilitate the development of pyridine‐based novel antibiotic/drug design in the near future as a versatile scaffold with limited side effects for the next‐generation therapeutics.

Insights into the factors and mechanisms of degradation, along with potential solutions.

The growing threat of environmental pollution to global environmental health necessitates a focus on the search for sustainable wastewater remediation materials coupled with innovative remediation strategies.