Alberto Mantovani

Dr. Alberto Mantovani

Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, viale Regina Elena, Roma, Italy
orcid

Research Focus & Metrics

Academic Career Length

53Years (1974-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 July 2008 in Nature
Verified
Journal Article
Closed access
Alberto MantovaniAlberto Mantovani
Alberto Mantovani
PAPaola Allavena
Paola Allavena
ASAntonio Sica
Antonio Sica
FBFrances Balkwill
Frances Balkwill

1 February 2001 in The Lancet
Verified
Journal Article
Closed access
FBFran Balkwill
Fran Balkwill
Alberto MantovaniAlberto Mantovani
Alberto Mantovani

1 July 2014 in Immunity
Verified
Journal Article
Closed access
PMPeter J. Murray
Peter J. Murray
JAJudith E. Allen
Judith E. Allen
SBSubhra K. Biswas
Subhra K. Biswas
EFEdward A. Fisher
Edward A. Fisher
DGDerek W. Gilroy
Derek W. Gilroy
TWThomas A. Wynn
Thomas A. Wynn

1 December 2004 in Trends in Immunology
Verified
Journal Article
Closed access
Alberto MantovaniAlberto Mantovani
Alberto Mantovani
ASA Sica
A Sica
SSSilvano Sozzani
Silvano Sozzani
PAPaola Allavena
Paola Allavena
AVA Vecchi
A Vecchi
MLMassimo Locati
Massimo Locati

1 March 2012 in Journal of Clinical Investigation
Verified
Journal Article
Open access
PDF file
ASAntonio Sica
Antonio Sica
Alberto MantovaniAlberto Mantovani
Alberto Mantovani
Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes of a continuum in a universe of activation states. Progress has now been made in defining the signaling pathways, transcriptional networks, and epigenetic mechanisms underlying M1-M2 or M2-like polarized activation. Functional skewing of mononuclear phagocytes occurs in vivo under physiological conditions (e.g., ontogenesis and pregnancy) and in pathology (allergic and chronic inflammation, tissue repair, infection, and cancer). However, in selected preclinical and clinical conditions, coexistence of cells in different activation states and unique or mixed phenotypes have been observed, a reflection of dynamic changes and complex tissue-derived signals. The identification of mechanisms and molecules associated with macrophage plasticity and polarized activation provides a basis for macrophage-centered diagnostic and therapeutic strategies.

1 November 2002 in Trends in Immunology
Verified
Journal Article
Closed access
Alberto MantovaniAlberto Mantovani
Alberto Mantovani
SSSilvano Sozzani
Silvano Sozzani
MLMassimo Locati
Massimo Locati
PAPaola Allavena
Paola Allavena
ASA Sica
A Sica