Flavonoids represent a class of natural plant secondary metabolites with multiple activities including antioxidant, antitumor, anti-inflammatory, and antimicrobial properties. However, due to their structural characteristics, they often exhibit low bioavailability in vivo. In this review, we focus on the in vivo study of flavonoids, particularly the effects of gut microbiome on flavonoids, including common modifications such as methylation, acetylation, and dehydroxylation, etc. These modifications aim to change the structural characteristics of the original substances to enhance absorption and bioavailability. In order to improve the bioavailability of flavonoids, we discuss two feasible methods, namely dosage form modification and chemical modification, and hope that these approaches will offer new insights into the application of flavonoids for human health. In this article, we also introduce the types, plant sources, and efficacy of flavonoids. In conclusion, this is a comprehensive review on how to improve the bioavailability of flavonoids.

Macrophomina phaseolina is a wide host ranged soil-borne fungal plant pathogen. It infects more than 500 host plant species belonging to 100 families. Many important oil-seed and leguminous crops are known to be attacked by this devastating plant pathogen. In the present study, antifungal potential of flowers of a leguminous tree Acacia nilotica subsp. indica, was assessed against this pathogen through bioassays guided fractionation. Initially, methanolic extracts of 1 %-5 % of leaf, flower, root-bark and stem-bark of the plant species under consideration were evaluated for their antifungal potential against the target pathogen. Among these, the best antifungal activity was shown by flower extract. The reduction in growth of the test fungal strain was 27-49 %, 4-40 % and 2-27 % due to flower, root-bark and leaf extracts, respectivey, over control. Flower extract was partitioned using n-hexane, chloroform, ethyl acetate and n-butanol as the solvents. Bioassays guided study of these fractions of methanolic extract of flower revealed that high antifungal potential was shown by n-hexane and chloroform fractions against M. phaseolina causing 26-53 % and 28-50 % decline in fungal biomass, respectively, as compared to that of control. GC-MS analysis of chloroform fraction revealed the presence of 27 compounds in this fraction. Among these cyclopentanol,-1-methyl (10.93 %) was the predominant compound followed by methyl, 4,4-dimethyl butanoate (7.04 %), 1-pentanol (6.80 %), 2-propanol, 1-cyclopropyl (6.11 %), 1H,imidazole-4-5-dihydro-2-methyl (5.93 %), trichloroethane (5.91 %), carbonic acid-ethyl hexyl ester (4.59 %), 1,4-butandiol,2,3-bis(methylene)- (4.54 %) and [S]-3,4-dimethyl pentanol (4.48 %).

Potato (Solanum tuberosum L.) cultivation in Pakistan faces challenges, with black scurf disease caused by Rhizoctonia solani Kühn being a significant concern. Conventional methods like chemical fungicides partially control it, but an effective solution is lacking. This study explores the potential of biofertilizers and soil amendments from Asteraceae weed biomass to manage the disease. Two potato varieties, Karoda and Sante, were chosen, and two biofertilizers, Fertibio and Feng Shou, were tested alone or with Xanthium strumarium biomass. Disease pressure was highest in the positive control, with significant reduction by chemical fungicide. X. strumarium biomass also decreased disease incidence significantly. Fertibio showed better efficacy than Feng Shou. Physiological and biochemical attributes of plants improved with biofertilizer and biomass application. Tuber weight, photosynthetic pigments, total protein content, and antioxidant enzymes (CAT, POX, and PPO) were positively correlated. Combined application of Fertibio and S. marianum biomass effectively managed black scurf disease. These eco-friendly alternatives could enhance disease management and yield. Future research should explore their cost-effectiveness, commercialization, and safety.

The importance of fruit shape studies extends beyond fundamental plant biology, as it holds significant implications for breeding. Understanding the genetic and hormonal regulation of fruit morphology can facilitate targeted breeding strategies to enhance yield, quality, and stress resistance, ultimately contributing to sustainable farming and nutrition security. The diversity in fruit shapes is the result of complex hormone regulation and molecular pathways that affect key traits, including carpel number, fruit length, and weight. Fruit shape is a quality attribute that directly influences consumer preference, marketability and the ease of post-harvest processing. This article focuses on investigations carried out on molecular, genetic and hormonal regulation mechanisms of fruit shape, color, maturation in fruit plants and key genetic pathways such as CLV-WUS and OVATE, as well as their roles in shaping non-climacteric fruits such as strawberries, grapes and raspberries. Plant hormones, especially abscisic acid (ABA) and indole-3-acetic acid (IAA), play a crucial role in enhancing desirable traits such as color and taste, while regulating anthocyanin synthesis and growth time. In addition, the dynamic interactions between auxin, gibberellin, and ethylene are crucial for the ripening process. Jasmonate enhances stress response, brassinosteroids promote ripening and cytokinins promote early fruit development. In addition, this review also studied the fruit morphology of species such as tomatoes and cucumbers, emphasizing the importance of the CLV-WUS pathway, which regulates the number of carpels through genes such as WUSCHEL (WUS), FRUITFULL1 (FUL1), and auxin response factor 14 (ARF14). The weight of fresh fruit is affected by microRNAs such as miRNA156, which emphasizes the importance of post transcriptional regulation. The involvement of transcription factors such as SISHN1, CaOvate, and CISUN25-26-27a further emphasizes the complexity of hormone regulation. Understanding these regulatory mechanisms can enhance our understanding of fruit development and have a profound impact on agricultural practices and crop improvement strategies aimed at meeting the growing global demand for high-quality agricultural products.

PPS Asteraceae is a large and widespread family of flowering plants, with 32 913 species commonly found in arid and semi-arid subtropical regions (Kew 2018). These plants are cultivated for their nutritional, medicinal, and ornamental value. These plants exhibit numerous pharmacological activities,