Background/Objectives: Dupuytren’s contracture is a chronic fibroproliferative disorder of the palmar fascia that leads to progressive flexion deformities and functional impairment. The Southampton Dupuytren’s Scoring Scheme (SDSS) is a disease-specific patient-reported outcome measure designed to quantify disability in this condition. This study aimed to translate, culturally adapt, and evaluate the psychometric properties of the Serbian version of the SDSS. Methods: A cross-sectional study was conducted at the Institute for Orthopedic Surgery “Banjica”, Belgrade, from January 2024 to March 2025. Sixty-eight patients with Dupuytren’s contracture completed the Serbian SDSS, the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire, the 12-Item Short Form Health Survey (SF-12), and a Visual Analogue Scale (VAS) for pain. Translation followed standardized forward–backward procedures. Internal consistency was assessed with Cronbach’s alpha, construct validity with confirmatory factor analysis (CFA), and convergent validity with Pearson’s correlation coefficients. Results: The Serbian SDSS demonstrated excellent internal consistency (Cronbach’s α = 0.914). CFA supported a unidimensional five-item structure with strong factor loadings (0.76–0.93) and acceptable fit indices (χ² = 10.094, df = 5, p = 0.073; IFI = 0.979; CFI = 0.978; TLI = 0.956). Convergent validity was confirmed by strong correlations with DASH (r = 0.779) and VAS (r = 0.702) and a strong negative correlation with SF-12 PCS (r = −0.802). Conclusions: The Serbian SDSS is a valid and reliable instrument for assessing functional disability in patients with Dupuytren’s contracture and offers a robust, patient-centered measure for clinical and research use.

Background/Objectives: Understanding the biological factors that drive the behavior and clinical presentation of breast cancer (BC) skeletal metastases (SM) is critical for improving diagnostic accuracy and guiding treatment strategies. However, evidence regarding the immunohistochemical (IHC) profiles of SM and their association with radiographic characteristics and clinical features remains limited. This study aimed to evaluate the relationship between estrogen receptor (ER), progesterone receptor (PR), HER2 receptor status, and Ki-67 proliferation index with the radiographic presentation of SM in patients with BC. Methods: A total of 185 SM samples from individual BC patients were analyzed. IHC expressions of ER, PR, HER2, and Ki-67 were determined for each sample. Clinical and radiological data were retrieved from medical records. IHC profiles were compared between metastases demonstrating purely lytic versus mixed radiographic patterns. Results: Of the 185 cases, 66 exhibited a lytic pattern, and 119 demonstrated a mixed pattern. Lytic metastases showed a significantly higher rate of HER2 positivity compared with mixed lesions. The Ki-67 index was also significantly higher in lytic metastases, with a cutoff value of 25 yielding a sensitivity of 92.98% and specificity of 89.84% (positive likelihood ratio 9.16; negative likelihood ratio 0.08). No significant differences were observed between groups in ER or PR expression. Conclusions: SM from BC with a lytic radiographic presentation are more likely to exhibit HER2 positivity and a Ki-67 index above 25. Assessing the IHC status of SM may help identify patients at elevated risk for skeletal complications, including pathological fracture, and may support more tailored surgical and systemic treatment planning.