Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable. Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.

Attachment theoretical studies have increased our understanding of the socioemotional foundations for religious development. However, because these studies have been correlational and based on self-reports, they are vulnerable to concerns of self-presentation bias and lack of basis for causal inference. Three subliminal stimulation experiments were therefore performed, where activation of the attachment system was attempted by way of unconsciously administered separation stimuli. In Experiments 1 and 3 (N = 29 and 89), the separation stimulus alluded to God, and in Experiment 2 (N = 47), it alluded to mother. Responses were moderated by perceived attachment history with parents in all experiments. Participants with secure histories increased in religious attachment behaviors, whereas those with insecure histories decreased following attachment system activation compared with control stimulation. There also were suggestions of experimental group increase in proximity seeking in relation to God. The main conclusion supports correspondence between internal working models of parents and God.