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Artem N. Fakhrutdinov graduated from Moscow State University of Fine Chemical Technologies in 2012 where he got experience in practical usage of NMR spectrometers. Then he was taken on the position of researcher in the Department of Structural Studies of N. D. Zelinsky Institute of Organic Chemistry. The research interests include structure determination of heterocycles and catalytic reaction intermediates by means of NMR spectroscopy, analysis of the chemical reaction paths and formation of side compounds and studying of decomposition of chemicals while storage.
The ammonium salts of many drugs have significantly improved the solubility and, accordingly, the bioavailability of medicinal substances in the human body. 5-(4-Hydroxy-2-oxo-2H-chromen-3-yl)-5H-chromeno[2,3-b]pyridines are potential NPY1R ligands, which are attractive for antiobesity treatment. Ammonium salts of 5H-chromeno[2,3-b]pyridines were previously unknown. In this communication, it was found that the four-component reaction of salicylaldehyde, 2-aminoprop-1-ene-1,1,3-tricarbonitrile, 4-Hydroxy-2H-chromen-2-one and amines results in the formation of ammonium salts of 5-(3-chromenyl)-5H-chromeno[2,3-b]pyridines. The structure of these previously unknown compounds was confirmed by means of 1H, 13C NMR and IR spectroscopy, mass spectrometry and elemental analysis.
Yuliya Ryzhkova; Artem Fakhrutdinov; Michail Elinson. Ammonium Salts of 5-(3-Chromenyl)-5H-chromeno[2,3-b]pyridines. Molbank 2021, 2021, M1219 .
AMA StyleYuliya Ryzhkova, Artem Fakhrutdinov, Michail Elinson. Ammonium Salts of 5-(3-Chromenyl)-5H-chromeno[2,3-b]pyridines. Molbank. 2021; 2021 (2):M1219.
Chicago/Turabian StyleYuliya Ryzhkova; Artem Fakhrutdinov; Michail Elinson. 2021. "Ammonium Salts of 5-(3-Chromenyl)-5H-chromeno[2,3-b]pyridines." Molbank 2021, no. 2: M1219.
A continuously growing interest in convenient and ‘green’ reaction techniques encourages organic chemists to elaborate on new synthetic methodologies. Nowadays, organic electrochemistry is a new useful method with important synthetic and ecological advantages. The employment of an electrocatalytic methodology in cascade reactions is very promising because it provides the combination of the synthetic virtues of the cascade strategy with the ecological benefits and convenience of electrocatalytic procedures. In this research, a new type of the electrocatalytic cascade transformation was found: the electrochemical cyclization of 1,3-dimethyl-5-[[3-hydroxy-6-(hydroxymethyl)-4-oxo-4H-pyran-2-yl](aryl)methyl]pyrimidine-2,4,6(1H,3H,5H)-triones was carried out in alcohols in an undivided cell in the presence of sodium halides with the selective formation of spiro[furo[3,2-b]pyran-2,5′-pyrimidines] in 59-95% yields. This new electrocatalytic process is a selective, facile, and efficient way to create spiro[furo[3,2-b]pyran-2,5′-pyrimidines], which are pharmacologically active heterocyclic systems with different biomedical applications. Spiro[furo[3,2-b]pyran-2,5′-pyrimidines] were found to occupy the binding pocket of aldose reductase and inhibit it. The values of the binding energy and Lead Finder’s Virtual Screening scoring function showed that the formation of protein–ligand complexes was favorable. The synthesized compounds are promising for the inhibition of aldose reductase. This makes them interesting for study in the treatment of diabetes or similar diseases.
Michail Elinson; Anatoly Vereshchagin; Yuliya Ryzhkova; Fedor Ryzhkov; Artem Fakhrutdinov; Mikhail Egorov. Efficient Electrocatalytic Approach to Spiro[Furo[3,2-b]pyran-2,5′-pyrimidine] Scaffold as Inhibitor of Aldose Reductase. Electrochem 2021, 2, 295 -310.
AMA StyleMichail Elinson, Anatoly Vereshchagin, Yuliya Ryzhkova, Fedor Ryzhkov, Artem Fakhrutdinov, Mikhail Egorov. Efficient Electrocatalytic Approach to Spiro[Furo[3,2-b]pyran-2,5′-pyrimidine] Scaffold as Inhibitor of Aldose Reductase. Electrochem. 2021; 2 (2):295-310.
Chicago/Turabian StyleMichail Elinson; Anatoly Vereshchagin; Yuliya Ryzhkova; Fedor Ryzhkov; Artem Fakhrutdinov; Mikhail Egorov. 2021. "Efficient Electrocatalytic Approach to Spiro[Furo[3,2-b]pyran-2,5′-pyrimidine] Scaffold as Inhibitor of Aldose Reductase." Electrochem 2, no. 2: 295-310.