Background: While the exact mechanisms are not fully understood, there are significant links between sleep quality, anxiety, depressive symptoms, and cognitive emotion regulation. This research examines how sleep quality affects anxiety and depressive symptoms, as well as the potential of cognitive emotion regulation strategies (CERS) to moderate the impact of sleep quality on these symptoms. Methods: The Chinese version of the Pittsburgh Sleep Quality Index (CPSQI), the Cognitive Emotion Regulation Questionnaire (CERQ), the Patient Health Questionnaire-9 (PHQ-9), and the Generalized Anxiety Disorder Scale-7 (GAD-7) were all completed online by students from two colleges in China’s Xizang region. Results: The study included 4325 subjects. The prevalence of poor sleep quality, anxiety symptoms, and depression symptoms was 45.69%, 36.81%, and 51.86%, respectively. We observed significant direct effects on poor sleep and severity of anxiety/depression: c’1 = 0.586 (0. 544–0.628), and c’2 = 0.728 (0.683–0.773). Adaptive CERS only had a mediating effect on the relationship between sleep quality and depression symptoms, with a1b3 = −0.005 (−0.011–−0.001). The link between poor sleep quality and the intensity of anxiety and depression was significantly affected by the indirect effects of maladaptive CERS: effect a2b2 = 0.126 (0.106–0.147), and effect a2b4 = 0.145 (0.123–0.167). Conclusions: Individuals who experience poor sleep quality are more likely to have increased levels of anxiety and depression. However, enhancing sleep quality led to a decrease in anxiety and depression levels. Adaptive CERS did not predict anxiety, but they did predict depression. Multiple maladaptive CERS could increase levels of anxiety and depression. To prevent mental stress, it is crucial to examine sleep problems among college students, understand their cognitive strategies, promote the adoption of adaptive CERS, and reduce the reliance on maladaptive CERS.

Objective: Nutritional deficiency, has recently received considerable attention as significant risk factor affecting global health. Nutritional deficiencies are a significant global burden associated with chronic disease. This study analyzed the burden of nutritional deficiencies in China from 1990 to 2021 based on age and gender, and compared it with the burden observed in global and G20 regions. This study aimed to understand the trends in nutritional deficiencies in China using this burden analysis and evaluate the changes in their burden to guide future public health policies. Method: This study utilized date from the global burden of disease database (GBD) for 2021, on the prevalence and years lived with disability (YLDs) attributed to nutritional deficiencies in China from 1990 to 2021. We analyzed the burden and temporal trends of nutritional deficiency in China based on gender, age, and region. Additionally, we analyzed the disease burden in the global and G20 regions, and compared it with the Chinese disease burden. We used estimated annual percentage change to reflect disease trends and subsequently utilized relevant cutting-edge technologies to predict the trends of nutritional deficiencies in China and global regions for 2035. Result: The burden of nutritional deficiencies in China demonstrated a significant declining trend from 1990 to 2021. China had more male patients with nutritional deficiencies in the < 5 age group than female patients, while the proportion of female patients was higher than that of males in other age groups, especially during pregnancy. Furthermore, dietary iron deficiency accounted for most of nutritional deficiency cases, contributing the largest share of the burden. From 1990 to 2021, epidemiological changes were the primary driver of the increased disease burden of nutritional deficiencies in China. Conclusion: The disease burden of nutritional deficiencies in China demonstrated a decreasing trend from 1990 to 2021. Meanwhile, the disease burden of nutritional deficiencies in the G20 and global regions demonstrated a significant declining trend. This may be associated with socioeconomic advancement. Regarding gender and age, the number of cases of nutritional deficiencies is highest among individuals aged 30 to 34 in China, with the highest number of female patients for nutritional deficiency far exceeding that of male patients of the same age group. This is associated with social factors, including poverty and social inequality. Social inequality and poverty increase the risk of illness among women. Regarding diseases, the disease burden of dietary iron deficiency is relatively high, followed by vitamin A deficiency. This may be linked to regional differences and dietary patterns in China.

Purpose: In order to further study the biological functions of glutathione peroxidases (GPXs) and their expression level in patients with osteoarthritis (OA), we fully explored the potential relationship between GPXs and OA. This will provide new ideas for basic biological studies and therapeutic strategies for OA patients. Patients and Methods: In this study, bioinformatics techniques were used to explore the biological functions of five GPXs. The core genes related to the biological functions of GPXs were identified by constructing a protein-protein interaction network (PPI). In addition, we utilized microarray data in public databases to analyze the expression levels of GPXs in OA patients and healthy controls. Finally, we used quantitative real-time polymerase chain reaction (qRT-PCR) to detect the expression of GPXs in OA patients and controls to validate our bioinformatic analysis results. Results: Enrichment analysis showed GPXs were mainly enriched in the glutathione metabolic pathway and participate in the biological process of oxidative stress response, and further play an antioxidant role. The PPI network indicated that superoxide dismutase 1 (SOD1), superoxide dismutase 2(SOD2) and catalase (CAT) were the core proteins of this network. GPX1 was regulated by the greatest number of miRNAs. Experiments showed that the expression of GPX1 was elevated in OA patients compared with controls. Conclusion: GPXs play an important antioxidant role in oxidative stress response. The expression of GPX1 was elevated in peripheral blood mononuclear cells (PBMCs) of OA patients. The changes of GPXs in OA patients may regulate the level of oxidative stress, which may influence synovial lesions and chondrocyte apoptosis.

Objective: To evaluate the differences between traditional Chinese medicine combined with western medicine and western medicine alone for the treatment of secondary tuberculosis and its impact on the evaluation of clinical efficacy and safety of patients in randomized controlled trials. Methods: A literature search of all major academic databases was conducted (PubMed, CNKI, Wanfang, VIP). Meta-analysis was conducted using RevMan 5.3 and Stata 12.0 software for those studies that satisfied the inclusion criteria. Ethical approval was not necessary because no people or animals were selected as subjects in this meta-analysis. Results: Twenty-three randomized controlled trials were included in this meta-analysis. The following indicators in the treatment group (traditional Chinese medicine decoction combined with western medicine chemotherapy) improved in comparison with those in the control group:focus absorption rate (RR:1.18; 95% CI: 1.15–1.22);sputum smear negative rate (RR: 1.17; 95% CI: 1.09–1.27);comprehensive clinical effective rate (RR: 1.18; 95% CI: 1.14–1.22);cavity closure rate (RR: 1.37; 95% CI: 1.12–1.67). The difference of Immune function indicator likes CD4+ level (SMD: 0.76; 95% CI: −0.25 to 1.76) between the treatment group and the control group was not significant. In addition, safety evaluation indicators like the decrease rate of white blood cell (WBC) and platelets (PLT) and the elevation rate of alanine aminotransferase (ALT) and uric acid (UA) in the treatment group were reduced compared with those in the control group (P < .05). Conclusions: The curative effect of combining traditional Chinese and western medicine for the treatment of secondary tuberculosis is better than that of western medicine alone and is conducive to reducing the incidence of adverse reactions.