Bao Zhu

Dr. Bao Zhu


Research Focus & Metrics

Academic Career Length

11Years (2016-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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11 January 2017 in BioMedical Engineering OnLine
Verified
Journal Article
Open access
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HLHongxia Li
Hongxia Li
TLTao Liu
Tao Liu
Minjie WangMinjie Wang
Minjie Wang
DZDanyang Zhao
Danyang Zhao
Aike QiaoAike Qiao
Aike Qiao
BZBao Zhu
Bao Zhu
Although stents have great success of treating cardiovascular disease, it actually undermined by the in-stent restenosis and their long-term fatigue failure. The geometry of stent affects its service performance and ultimately affects its fatigue life. Besides, improper length of balloon leads to transient mechanical injury to the vessel wall and in-stent restenosis. Conventional optimization method of stent and its dilatation balloon by comparing several designs and choosing the best one as the optimal design cannot find the global optimal design in the design space. In this study, an adaptive optimization method based on Kriging surrogate model was proposed to optimize the structure of stent and the length of stent dilatation balloon so as to prolong stent service life and improve the performance of stent. A finite element simulation based optimization method combing with Kriging surrogate model is proposed to optimize geometries of stent and length of stent dilatation balloon step by step. Kriging surrogate model coupled with design of experiment method is employed to construct the approximate functional relationship between optimization objectives and design variables. Modified rectangular grid is used to select initial training samples in the design space. Expected improvement function is used to balance the local and global searches to find the global optimal result. Finite element method is adopted to simulate the free expansion of balloon-expandable stent and the expansion of stent in stenotic artery. The well-known Goodman diagram was used for the fatigue life prediction of stent, while dogboning effect was used for stent expansion performance measurement. As the real design cases, diamond-shaped stent and sv-shaped stent were studied to demonstrate how the proposed method can be harnessed to design and refine stent fatigue life and expansion performance computationally. The fatigue life and expansion performance of both the diamond-shaped stent and sv-shaped stent are designed and refined, respectively. (a) diamond-shaped stent: The shortest distance from the data points to the failure line in the Goodman diagram was increased by 22.39%, which indicated a safer service performance of the optimal stent. The dogboning effect was almost completely eliminated, which implies more uniform expansion of stent along its length. Simultaneously, radial elastic recoil (RR) at the proximal and distal ends was reduced by 40.98 and 35% respectively and foreshortening (FS) was also decreased by 1.75%. (b) sv-shaped stent: The shortest distance from the data point to the failure line in the Goodman diagram was increased by 15.91%. The dogboning effect was also completely eliminated, RR at the proximal and distal ends was reduced by 82.70 and 97.13%, respectively, and the FS was decreased by 16.81%. Numerical results showed that the fatigue life of both stents was refined and the comprehensive expansion performance of them was improved. This article presents an adaptive optimization method based on the Kriging surrogate model to optimize the structure of stents and the length of their dilatation balloon to prolong stents fatigue life and decreases the dogboning effect of stents during expansion process. Numerical results show that the adaptive optimization method based on Kriging surrogate model can effectively optimize the design of stents and the dilatation balloon. Further investigations containing more design goals and more effective multidisciplinary design optimization method are warranted.

28 December 2016 in BioMedical Engineering OnLine
Verified
Journal Article
Open access
PDF file
HLHongxia Li
Hongxia Li
Junfeng GuJunfeng Gu
Junfeng Gu
Minjie WangMinjie Wang
Minjie Wang
DZDanyang Zhao
Danyang Zhao
Zheng LiZheng Li
Zheng Li
BZBao Zhu
Bao Zhu
In stent design optimization, the functional relationship between design parameters and design goals is nonlinear, complex, and implicit and the multi-objective design of stents involves a number of potentially conflicting performance criteria. Therefore it is hard and time-consuming to find the optimal design of stent either by experiment or clinic test. Fortunately, computational methods have been developed to the point whereby optimization and simulation tools can be used to systematically design devices in a realistic time-scale. The aim of the present study is to propose an adaptive optimization method of stent design to improve its expansion performance. Multi-objective optimization method based on Kriging surrogate model was proposed to decrease the dogboning effect and the radial elastic recoil of stents to improve stent expansion properties and thus reduce the risk of vascular in-stent restenosis injury. Integrating design of experiment methods and Kriging surrogate model were employed to construct the relationship between measures of stent dilation performance and geometric design parameters. Expected improvement, an infilling sampling criterion, was employed to balance local and global search with the aim of finding the global optimal design. A typical diamond-shaped coronary stent-balloon system was taken as an example to test the effectiveness of the optimization method. Finite element method was used to analyze the stent expansion of each design. 27 iterations were needed to obtain the optimal solution. The absolute values of the dogboning ratio at 32 and 42 ms were reduced by 94.21 and 89.43%, respectively. The dogboning effect was almost eliminated after optimization. The average of elastic recoil was reduced by 15.17%. This article presents FEM based multi-objective optimization method combining with the Kriging surrogate model to decrease both the dogboning effect and radial elastic recoil of stents. The numerical results prove that the proposed optimization method effectively decreased both the dogboning effect and radial elastic recoil of stent. Further investigations containing more design goals and more effective multidisciplinary design optimization method are warranted.

22 May 2019 in Journal of Tribology
Verified
Journal Article
Closed access
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BZBao Zhu
Bao Zhu
YCY. J. Cai
Y. J. Cai
YLY. P. Li
Y. P. Li
MLM.K. Lei
M.K. Lei
DGD. M. Guo
D. M. Guo
Recent experiments have shown that the elastic deformation behaviors of a polymeric material are consistent with the Cosserat elasticity under nonuniform deformation at a millimeter scale. Thus, an elastohydrodynamic lubrication model in the framework of the Cosserat continuum theory is proposed to explore the lubrication performance that deviates from the classical elastohydrodynamic lubrication theory for the small polymer journal bearings with millimeter size. The elastic deformation of the bearing sleeve made of polymeric material and the pressure distribution in a lubricating film are obtained through an iterative solution of the equation of the Cosserat elasticity and the modified Reynolds’ equations with considering the boundary slippage. The effect of bearing size and Cosserat characteristic lengths for torsion and bending on the lubrication performance of the small polymer journal bearings is studied using the proposed Cosserat elastohydrodynamic lubrication model. It was found that the small changes in film thickness due to the Cosserat effect can result in large changes in film pressure. The Cosserat characteristic length of bending possesses a significant effect on the lubrication behaviors of the journal bearings, because the size effect is mainly caused by the increased apparent modulus due to the bending elastic deformation of the bearing sleeve. The boundary slip behaviors dependent on the Cosserat characteristic length are also studied using the Cosserat elastohydrodynamic model, and the numerical results show that the Cosserat characteristic length changes the optimal geometric parameters of the slip zone in terms of load carrying capacity for the small polymer journal bearings.

15 July 2024 in Measurement Science and Technology
Verified
Journal Article
Closed access
BZBao Zhu
Bao Zhu
CHChunmeng He
Chunmeng He
The conventional deep learning-based bearing fault diagnosis methods tend to utilize denoising modules to improve the fault diagnosis performance in noisy scenes. However, the addition of denoising modules will increase expensive computational costs, leading to a delayed acquisition of fault diagnosis results. This work proposed a lightweight batch normalization (BN)-free residual network without any denoising modules for bearing fault diagnosis which properly rescaled the weights in a standard initialization instead of BN to avoid the exploding gradient problem and vanishing gradient problem at the beginning of training for deep neural networks. Therefore, it prevents the undesirable properties caused by BN. Compared with other methods, the fault diagnosis performance of the proposed method can maintain a high level with different input sizes and batch sizes. Especially in noisy scenes, the testing accuracy of fault diagnosis on different bearing datasets can be improved by 13.54% and 7.74% using fewer parameters and floating point operations on different bearing datasets.

21 October 2019 in Journal of Micro and Nano-Manufacturing
Verified
Journal Article
Closed access
PDF file
YLYupeng Li
Yupeng Li
XLXia Liu
Xia Liu
XLXiaoyu Li
Xiaoyu Li
BZBao Zhu
Bao Zhu
MLM.K. Lei
M.K. Lei
ALAkhlesh Lakhtakia
Akhlesh Lakhtakia
Inspired by the anti-reflection functionality of cicada wings decorated with nanocone arrays, a facile technique to endow flexible polymer substrates of diverse chemical compositions with the same functionalities has been devised. In this universally applicable two-step technique based on a capacitatively coupled radiofrequency plasma (CCRP), first oxygen-plasma treatment (OPT) is implemented to grow arrays of vertical elongated nanostructures with almost uniform cross-sectional diameter of the polymer substrate, and then fluorocarbon polymer deposition (FPD) is carried out so that the nanostructures evolve into nanocones with small apex angle. The dependence of ion-bombardment-induced sputtering on the local impingement angle of ions taper the vertical nanostructures into the nanocones during the FPD under CCRP. The nanocone arrays exhibit low specular reflectance in a broad wavelength range and a wide incidence angle range that is quite insensitive to the polarization state of the incident light. The effective refractive index gradient of irregularly arranged nanocone arrays is characterized from the refractive index of the fluorocarbon polymer and the volume fraction considering the nanocone probability with the Gaussian distribution. The excellent broadband and omnidirectional anti-reflection properties are in consequence of a graded refractive index.

3 April 2024 in Journal of the Mechanical Behavior of Biomedical Materials
Verified
Journal Article
Closed access
HLHongxia Li
Hongxia Li
XGXuewen Guo
Xuewen Guo
BZBao Zhu
Bao Zhu