This study critically examines the applications of the Hydrologic Engineering Center-Hydrologic Modeling System (HEC-HMS) in hydrological research from 2000 to 2023, with a focus on its use in event-based and continuous simulations. A bibliometric analysis reveals a steady growth in research productivity and identifies key thematic areas, including hydrologic modeling, climate change impact assessment, and land use analysis. Event-based modeling, employing methods such as the SCS curve number (CN) and SCS unit hydrograph, demonstrates exceptional performance in simulating short-term hydrological responses, particularly in flood risk management and stormwater applications. In contrast, continuous modeling excels in capturing long-term processes, such as soil moisture dynamics and groundwater contributions, using methodologies like soil moisture accounting and linear reservoir baseflow approaches, which are critical for water resource planning and climate resilience studies. This review highlights the adaptability of HEC-HMS, showcasing its successful integration of event-based precision and continuous process modeling through hybrid approaches, enabling robust analyses across temporal scales. By synthesizing methodologies, performance metrics, and case studies, this study offers practical insights for selecting appropriate modeling techniques tailored to specific hydrological objectives. Moreover, it identifies critical research gaps, including the need for advanced calibration methods, enhanced parameter sensitivity analyses, and improved integration with hydraulic models. These findings highlight HEC-HMS’s critical role in improving hydrological research and give a thorough foundation for its use in addressing current water resource concerns.