Benoit received his PhD in Immunology at the Alternative Energies and Atomic Energy Commission (CEA) in Paris, France. During his PhD, he worked on non-human primate models, and studied the innate response of macaques to Simian Immunodeficiency Virus (SIV) infection. He subsequently moved from Paris to Singapore to take up a post-doctoral research position to study malaria parasites and host cell tropism at the Singapore Immunology Network (SIgN), A*STAR. In 2018, Benoit became an Assistant Professor in the Department of Microbiology and Immunology and his lab focuses on erythrocytic immunobiology, zoonotic infections including zoonotic malaria and tick-borne diseases.