The research projects in Shih-Chang Tsai's lab focus on exploring gene regulation in cancer cells, investigating microRNA in human cancers. Their work analyzes miRNA expression profiling in cancer patients and identify the potential targets of miRNA. In addition, they explore the molecular mechanisms (including apoptosis, autophagy, and migration) of natural products and anti-cancer drugs in treating cancer. Recent work has focused on controlling the development of nonalcoholic fatty liver disease (NAFLD).