Novel plasma-based technologies that offer maximum efficiency at minimal environmental costs are expected to further promote the sustainable societal and economic development. Unique transfer of chemical reactivity and energy from gaseous plasmas to water takes place in the absence of any other chemicals, but results in a product with a notable transient broad-spectrum biological activity, referred to as plasma-activated water (PAW). These features make PAW a green prospective solution for a wide range of biotechnology applications, from water purification to biomedicine. Here, we present a succinct review of how novel, efficient methods based on non-equilibrium reactive plasma chemistries can be applied to low-cost natural water sources to produce a prospective product with a wide range of applications while at the same time minimising the process steps and dramatically reducing the use of expensive and/or hazardous reagents. Despite the recent exciting developments in this field, there presently is no topical review which specifically focuses on the underlying physics and chemistry related to plasma-activated water. We focus specifically on the PAW generation, origin of reactive species present in PAW, its related analytical chemistry and potentially different mechanisms that regulate the bio-activities of PAW in different biotech-applications and their roles in determining PAW efficacy and selectivity. We then review recent advances in our understanding of plasma-water interactions, briefly outlining current and proposed applications of PAW in agriculture, food and biomedicine. Finally, we outline future research directions and challenges that may hinder translation of these technologies into real-life applications. Overall, this review will provide much needed insights into the fundamental aspects of PAW chemistry required for optimization of the biochemical activity of PAW and translation of this environment- and human-health-friendly, and energy-efficient strategy into real life applications.

Low temperature plasmas have been used in various plasma processing applications for several decades. But it is only in the last thirty years or so that sources generating such plasmas at atmospheric pressure in reliable and stable ways have become more prevalent. First, in the late 1980s, the dielectric barrier discharge was used to generate relatively large volume diffuse plasmas at atmospheric pressure. Then, in the early 2000s, plasma jets that can launch cold plasma plumes in ambient air were developed. Extensive experimental and modeling work was carried out on both methods and much of the physics governing such sources was elucidated. Starting in the mid-1990s, low temperature plasma discharges have been used as sources of chemically reactive species that can be transported to interact with biological media, cells, and tissues and induce impactful biological effects. However, many of the biochemical pathways whereby plasma affects cells remain not well understood. This situation is changing rather quickly because the field, known today as “plasma medicine,” has experienced exponential growth in the last few years thanks to a global research community that engaged in fundamental and applied research involving the use of cold plasma for the inactivation of bacteria, dental applications, wound healing, and the destruction of cancer cells/tumors. In this perspective, the authors first review the physics as well as the diagnostics of the principal plasma sources used in plasma medicine. Then, brief descriptions of their biomedical applications are presented. To conclude, the authors' personal assessment of the present status and future outlook of the field is given.

A single electrode room-temperature atmospheric pressure plasma plume generated between a high-voltage electrode and the surrounding room air is reported. The plasma plume has a peak current of about 360mA. This is highest current carried by a room-temperature plasma plume ever reported. The rotational and vibrational temperature of the plasma plume is about 300 and 2950K, respectively. Emission spectra show that excited species, such as O, OH, N2+, etc., are present in the plasma plume.

Guided ionization waves, or plasma streamers, are increasingly important for many applications in spanning materials processing and biomedicine. The highly reproducible, repeatable behavior of the most puzzling kind of the streamers–plasma bullets is highly attractive as it promises a high degree of control in many applications. However, despite a dozen years since the discovery of this phenomenon, the exact reasons for such behavior still remain essentially unclear. To understand the dynamics of the guided ionization wave (plasma bullet), a large number of works have been carried out and many interesting results have been reported. Here, we critically examine the available results and generalize the physical mechanisms of the guided ionization waves, which are of particular interest to practical applications of atmospheric-pressure plasma discharges, in general. The critical examination of the fundamental principles will show that, in order to propagate in a repeatable-mode, the plasma bullet must propagate in a channel with a high seed electron density (HSED), which is on the order of 10⁹ cm⁻³. This review concludes that to distinguish guided ionization waves from traditional positive streamer discharges, it is most appropriate to describe an atmospheric-pressure discharge featuring a plasma bullet behavior as an HSED discharge. When the HSED condition is met, the dynamics of a plasma plume appears to be repeatable. On the contrary, it propagates in an unrepeatable mode and emerges more like a positive streamer discharge when the HSED condition is not satisfied. According to this theory, the transition of the propagation mode of the plasma bullet between the repeatable mode and the stochastic mode can be well explained. Besides by controlling the seed electron density around the transition region between the HSED discharge and the traditional positive streamer, this knowledge will help in better understanding of the positive streamer discharges in air, in cases relevant to practical applications of such plasma discharges in materials processing technologies, industrial chemistry, nanotechnology, and health care.

Plasma, the fourth and most pervasive state of matter in the visible universe, is a fascinating medium that is connected to the beginning of our universe itself. Man-made plasmas are at the core of many technological advances that include the fabrication of semiconductor devices, which enabled the modern computer and communication revolutions. The introduction of low temperature, atmospheric pressure plasmas to the biomedical field has ushered a new revolution in the healthcare arena that promises to introduce plasma-based therapies to combat some thorny and long-standing medical challenges. This paper presents an overview of where research is at today and discusses innovative concepts and approaches to overcome present challenges and take the field to the next level. It is written by a team of experts who took an in-depth look at the various applications of plasma in hygiene, decontamination, and medicine, made critical analysis, and proposed ideas and concepts that should help the research community focus their efforts on clear and practical steps necessary to keep the field advancing for decades to come.