The global agri-food system generates substantial volumes of waste annually, 150 billion metric tons an amount projected to grow by 7.5 % each year, including crop residues, food processing by-products, and consumer discards. These wastes, if unmanaged, contribute to environmental harm and loss of valuable nutrients. The Research Topic "Agri-Food Waste Utilization for a Sustainable Future: Challenges and Opportunities" compiles interdisciplinary research aimed at transforming agri-waste/by-products, into valuable resources through valorization, lifecycle assessments, economic analyses, and policy frameworks-paving the way for circular and sustainable food systems.Several studies under this theme highlight innovative uses of agricultural wastes in diverse sectors. Jalal Uddin et al. 1 report the successful use of polyphenol oxidase (PPO) enzymes from fruit and vegetable peels in biodegrading and decolorizing industrial azo dyes. PPO extracted from Solanum tuberosum achieved an 83.29% decolorization efficiency against Reactive Black-5, revealing the potential of agro-waste-derived enzymes in eco-friendly wastewater management. Arable crops processing generates lots of waste streams like stale bread, other wastes from bread industry, legumes like soybean processing into tofu, protein isolates generates most notably soybean dregs (okara) and soybean whey which have huge potential for upscaling. In this track, Hafyan et al. 2 review the potential of bread waste (BW) as a feedstock for producing valuable biochemicals. Unlike lignocellulosic biomass, demanding harsh pretreatment and cumbersome decomposition reactions, BW characterized by its starchy composition and cost-effectiveness is readily accessible and has immense potential as sustainable feedstock for bioenergy and high-value biochemicals. Despite its promise in a circular bioeconomy, challenges remain, including low technological readiness, cost-effectiveness, and public acceptance. The review stresses the need for integrated sustainability assessments to scale BW-based biorefineries, provides sustainability assessment, through life cycle anslysis, technoeconomic feasibility, social lifecycle and draws out current challenges and concludes with chalking a future strategic approach for BW utilization. Similarly, Shen et al. 3 explore the use of screw extrusion as a scalable method for treating underutilized soybean by-products. Considering the consequences of residual metal ions, excessive protein residues and microbial contamination in soybean whey, they propose extraction of isoflavones from soy whey. They advocate the use of extrusion technology to leverage thermal and mechanical means to convert nutrient-rich residues into value-added products, addressing contamination concerns and reducing environmental impacts. They conclude with enlisting the advantages, limitations, and further scope of extrusion technology for soybean by-product processing.Besides food and agricultural waste, increased urbanization and industrialization globally has resulted into a sudden increase in wastewater production. Ghanbari et al. 4 emphasize the reuse of wastewater and biosolids in agriculture to reap social and economic benefits and promote the sustainability of agriculture and the environment. They employed MAXQDA to organize and code the collected data from scientific articles and expert interviews, conduct systematic analysis of the components affecting sustainable management of wastewater use in agriculture. A comprehensive framework for the sustainable management of wastewater in agriculture has been provided with IQCA method wherein they have identified six key components-economic, environmental, contextual, individual, management and planning, and education and extension-that are critical for successful reuse of purified waste water. Emphasizing education and stakeholder engagement, the study provides a practical guide for developing inclusive, sustainable water strategies.Apart from agriculture, waste from households also account for considerable environmental load. In Japan alone, 2.44 million tons (almost half of the total food waste) came from households (Morais and Ishida 5 ). Theory of Consumption Values (TCV) was applied to understand household composting behavior among Japanese households 5 . Use of categorical PLS-SEM approach identified key motivators like social approval, knowledge, convenience, and interest in gardening. Functional value, such as ease of use, played a central role, while emotional factors and demographics had minimal impact. Morais and Ikshida 5 highlight the importance of community initiatives and educational outreach in mainstreaming household composting.India produces ~27 million MT onions, contributing widely to global consumption. Onions processing into various value-added products like dehydrated onion, onion paste, pre-cut onions generates large amounts of waste, in the form of outer skins, peels, and trimmings. Disposal of this waste is challenging for industries owing to strong characteristic odour of sulphur containing compounds. Gorrepati et al. 6 assessed the nutraceutical potential of onion peels, from eight dark red varieties as a potential source of high-value secondary metabolites. These peels showed high total phenolic and anthocyanin contents, along with strong antioxidant activity. They reported that red coloured variety BSR had 49 identified phenolic compounds, including nine flavanol, four flavones, and thirty anthocyanin glycosides. In contrast, white onion varieties had five flavanol and eleven anthocyanins. With anthocyanin content as high as 28 mg/100g in some varieties, these can be well exploited for use in functional food and dietary supplement development. Similarly in Taiwan, Grouper aquaculture represents a significant sector for processed seafood. It also generates substantial by-products, posing challenges for waste management and environmental sustainability. Grouper bone...