We report here the first elastically bendable single component pharmaceutical crystal, celecoxib. Interlocked molecular packing without slip plane and the presence of isotropic hydrogen bond network are major structural features responsible for both the exceptional elastic flexibility and high stiffness of the celecoxib crystal revealed by bending and nanomechanical studies. The molecular model of the exceptional elasticity is rationalized by the inhomogeneous spatial separations of mole-cules in the bent crystal, which is further confirmed by micro-Raman spectroscopy. Celecoxib crystal, exhibiting both thera-peutic effects and elastic mechanical behavior, could be used to manufacture functional micro-devices with novel medical applications.