Background: This study aimed to analyze and determine the incidence and mortality trends in gynecological and breast cancers (BCs) in Poland. The gynecological cancers assessed were cervical cancer (CC), corpus uteri cancer (CUC), ovarian cancer (OC), vaginal cancer (VAC), and vulvar cancer (VUC). Patients and Methods: Data concerning the incidence and mortality for the period of 1980– 2018 were obtained from the Polish National Cancer Registry (PNCR). Joinpoint regression analysis was performed to identify trends, which were described using the annual percentage change (APC) and the average annual percent change (AAPC). Results: Statistically significant increases were observed in BC incidence (AAPC: 2.3; CI: 1.8 to 2.9; p< 0.05), CUC incidence (AAPC: 2.3; CI: 1.9 to 2.7; p< 0.05), CUC mortality (AAPC: 0.4; CI: 0.1 to 0.7; p< 0.05) and VUC mortality (AAPC: 1.16, CI: 0.1 to 2.2; p< 0.05). VAC mortality decreased (AAPC: − 3.5, CI: − 5.0 to – 2.0; p< 0.05), as did CC incidence and mortality (AAPC: − 2.1, CI: − 2.3 to − 1.8; p< 0.05, AAPC: − 2.0, CI: − 2.2 to – 1.8; p< 0.05, respectively). Between 1980 and 1993, OC incidence initially increased and then stabilized (AAPC: 0.9; CI: 0.7 to 1.1; p< 0.05). After 2007, OC mortality decreased (AAPC: 0.0; CI: − 0.2 to 0.2; p=0.8). Trends in VUC and VAC incidence and BC mortality were not statistically significant. Conclusion: The results of this study showed a significant increase in OC, CUC, and BC incidence, and a decrease in the incidence of CC and VAC. The VUC trends were stable. Mortality trends for BC initially fluctuated and, since 2010, has begun to increase. Throughout the observed period, mortality due to VUC and CUC increased, whereas decreased among patients with CC. OC mortality was stable, but not significant. Furthermore, the study showed a correlation between age group and rate of incidence and mortality of each assessed cancer.

The radial approach (RA) is the most common in invasive cardiology, but depending on the clinical situation, the femoral approach (FA) and brachial approach (BA) are also used. The BA is associated with the highest odds of complications so it is used mainly if a first-choice approach fails. The aim of the study was to assess clinical outcomes after invasive cardiology procedures stratified by the use of the RA, FA, and BA, with a focus on access site-related complications, quality of life (QoL), and patients’ perspective. A total of 250 procedures (RA: 98; FA: 99; BA: 53) performed between 2013 and 2020 were retrospectively analyzed. Puncture site-related complications, vascular events, patient preferences, and QoL were assessed by the analysis of medical records and telephone follow-up using a proprietary questionnaire and the modified EQ-5D-3L questionnaire. Patients from the RA group received the smallest volume of contrast during a percutaneous coronary interventions (PCI) procedure (RA vs. FA vs. BA: 180 (150–240) mL vs. 200 (180–270) mL vs. 190 (100–200) mL, p = 0.045). The access site was changed most frequently in the procedures initiated from the RA (p < 0.04). Overall puncture site-related complications, especially local hematomas, occurred most commonly in the BA group (7.1, 14.1, and 24.5% for RA, FA, and BA, respectively, p = 0.01). During the index procedure, the access site was changed most frequently in procedures initiated from the RA (19.7, 8.5 and 0%, p = 0.04). The RA was indicated as an approach preferred by the patient for a hypothetical next procedure (87.9, 55.4, and 70.0% for subjects preferring the same approach out of patients who underwent a procedure by the RA, FA, and BA, respectively, p < 0.001). For the RA and FA, the prevalence of moderate or extreme access site-related problems in self-care decreased significantly (RA: p < 0.01, FA: p < 0.05) within 1 month after the index procedure (RA: 18.1, 4.2, and 1.4%; FA: 20.7, 11.1, and 9.6% periprocedurally, after 1 and 6 months, respectively). In contrast, for the BA these percentages were higher and a significant improvement (p < 0.05) was delayed until 6 months (54.6, 36.4, and 18.2% periprocedurally, after 1 and 6 months, respectively). In conclusion, compared to the BA and FA, the RA appears to be not only the safest, mainly due to the lowest risk of puncture site-related complications after coronary procedures but also represents a preferable approach from the patient’s perspective. Although overall post-procedural QoL outcomes did not differ significantly according to the access site, nevertheless, the BA was associated with more frequent self-care problems whose improvement was delayed until more than one month after the index procedure.

Comparison of Suicidal Poisonings with Chemicals and Drugs in the Years 1930–1939 and 2010–2019 in the Materials of the Forensic Medicine Institute in Krakow The study aims to compare suicide poisoning and poisons used to commit suicide in the 1930s and today. The focus is on autopsy protocols from 1930–1939 and 2010–2019 collected at the Forensic Medicine Institute in Krakow. In the years 1930–1939, there were 184 cases, 65 of which were among men and 119 among women. The most common poisons were corrosives, accounting for 69 cases, 43 were carbon monoxide, 24 were drugs and narcotics, 17 were heavy metals, and the remaining 31 were other substances. Of the 138 suicide poisonings in modern times, 96 were committed by men and 42 by women. The most common poisoning was multi-drug poisoning – 62 cases. Opioids, benzodiazepines, neuroleptics and antidepressants were the most frequently chosen substances today. Fatal intoxications with drugs/new psychoactive substances (NCAs) were observed in 28 cases, while other substances were used in the remaining 17. The conducted analysis showed a significant decrease in suicidal poisoning with the use of corrosive substances and gases, while the percentage of drug overdoses is systematically growing. Poisons used for suicide purposes in the 1930s left macroscopic changes that could be instantly noticed during the autopsy. The fact that drugs that are currently used most often do not leave such changes may justify the dynamic development of forensic toxicology.

Introduction Analysis of different methods of performing illegal abortions and causes of death in women who underwent the procedure during the interwar period. Material and methods The study was based on the autopsy protocols from 1920-1939 archived at the Department of Forensic Medicine,...

Aim: Analysis of the frequency of infanticides in years 1930s, 1970s and nowadays. Materials and methods: Section protocols collected at the Department of Forensic Medicine in Kraków from years 1930–1939, 1971–1980 and 2012–2021 were investigated. Cases of infanticides were gathered and analysed. Results: We analyzed 295 cases, 7 from years 2012–2021, 134 from years 1971–1980, and 154 from years 1930–1939. In years 2012–2021, 5 cases were certain infanticides (1 commision – active and 4 omissions – passive), in the other 2 cases, the abandoned carcass of a newborn was thoroughly decomposed. In 1970s, 46 cases were definite infanticides (19 commisions and 27 omissions). In 38 cases, due to significant damage to the corpse, it was impossible to determine the cause of death and to confirm infanticide. We also discovered 5 cases of stillborn, abandoned newborns. In 21 cases, the body of a child whose direct cause of death was the perinatal trauma was abandoned, and in 23 cases abandoned children were underdeveloped; one case was uncategorized. In 1930s, 40 cases were certain infanticides (15 commisions and 25 ommisions). In 30 cases, due to significant damage to the corpse, it was impossible to confirm or rule out infanticide. We discovered 6 cases of stillborn abandoned newborns. In 18 cases, the body of a child whose direct cause of death was perinatal trauma was abandoned, and in 60 cases abandoned children were underdeveloped and therefore unable to survive. Conclusions: Nowadays the infanticides are quite rare, however in 1970s they were quite common, occurring almost as often as in 1930s.

Cerebral venous sinus thrombosis (CVST) is a rare type of stroke caused by a clot forming in one of the cerebral sinuses and subsequent blockage in blood drainage. The clinical presentation of this disease can be atypical and diagnosis might be challenging. The patient in this case study was a 33-year-old woman admitted to the perinatology clinic at 39⁺⁵ weeks of gestation to perform a planned caesarean section, who had previously been discharged home in good condition. The patient was readmitted to the hospital because of a headache, tingling sensation, and elevated D-dimers. A performed Computed Tomography scan revealed low contrast signal in the left cerebral sinuses and the left internal jugular vein. The diagnosis was CVST, with blood clots present in all mentioned vessels. Subsequent magnetic resonance imaging revealed hemorrhagic venous infarctions in the left cerebral and cerebellar hemispheres. The patient was successfully treated with painkillers and heparin. No additional coagulation defect was detected.