Recent regional research has taken an ‘infrastructure turn’ where scholars have called for examining the transformative ability of different infrastructures in causing systemic inequities beyond the spatial conception of ‘urban and the other’. This research examines the interconnected impact of infrastructure systems on existing spatial inequities through a study in metropolitan Philadelphia, Pennsylvania. This study investigates whether the urban-rural (U-R) gradient concept can enhance understanding of the spatial relationship between socioeconomic indicators and infrastructure systems. Indicators of spatial inequalities were regressed against infrastructure variables and imperviousness, as a proxy for the U-R gradient, using multivariate and spatial regression methods. The models show that imperviousness has a positive correlation with the concentration of racialized minorities and a negative correlation with access to health insurance. The study also shows that the predictive power of multiple infrastructures varies across space and does not adhere to urban boundaries or the U-R gradient. The complex interactions among different infrastructures shape inequities and require further inquiry in urban regions around the world.