Motivated by the aging trend, much effort is being invested into implementing ICT (Information and Communications Technology)-enabled systems to provide a better quality of life and support the independent living of older people. As a result, many systems, often labeled as eHealth or AAL (Ambient/Active Assisted Living), were developed over the years. In creating such systems, which very often serve various needs, different architectures have emerged. This work focuses on analyzing and comparing the work and architectures from seven (six of which are in progress) EU-funded healthcare projects, with a total budget of 126MEUR in which we participate. After establishing the theoretical foundation by defining core concepts, we give a brief background on architectures in eHealth and AAL. We elaborate on the chosen analysis method based on three established healthcare and AAL taxonomies we identified by performing a literature survey and the selected Reference Architecture Model (RAM). Since there is no standard way of describing architectures in the eHealth and AAL domain, we conducted the online survey during August and September 2020 and identified CREATE-IoT 3D RAM as the most appropriate option. We present a classification of selected projects based on established taxonomies and map projects’ architectures to CREATE-IoT 3D RAM, which we also propose as standard RAM for future digital healthcare and AAL projects. During our analysis, we identify the most common types of assistance: communication support, reminders, monitoring, and guidance to address health and communication issues. We conclude that proper ecosystems are critical for lowering entry barriers and facilitating sustainable solutions for smart and healthy living.

Due to population ageing and medical advances, people with advanced chronic diseases (ACD) live longer. Such patients are even more likely to face either temporary or permanent reduced functional reserve, which typically further increases their healthcare resource use and the burden of care on their caregiver(s). Accordingly, these patients and their caregiver(s) may benefit from integrated supportive care provided via digitally supported interventions. This approach may either maintain or improve their quality of life, increase their independence, and optimize the healthcare resource use from early stages. ADLIFE is an EU-funded project, aiming to improve the quality of life of older people with ACD by providing integrated personalized care via a digitally enabled toolbox. Indeed, the ADLIFE toolbox is a digital solution which provides patients, caregivers, and health professionals with digitally enabled, integrated, and personalized care, supporting clinical decisions, and encouraging independence and self-management. Here we present the protocol of the ADLIFE study, which is designed to provide robust scientific evidence on the assessment of the effectiveness, socio-economic, implementation, and technology acceptance aspects of the ADLIFE intervention compared to the current standard of care (SoC) when applied in real-life settings of seven different pilot sites across six countries. A quasi-experimental trial following a multicenter, non-randomized, non-concurrent, unblinded, and controlled design will be implemented. Patients in the intervention group will receive the ADLIFE intervention, while patients in the control group will receive SoC. The assessment of the ADLIFE intervention will be conducted using a mixed-methods approach.

Objective: Integrated care and digital health technology interventions are promising approaches to coordinate services for people living with chronic conditions, across different care settings and providers. The EU-funded ADLIFE project intends to provide digitally integrated personalized care to improve and maintain patients’ health with advanced chronic conditions. This study conducted a qualitative assessment of contextual factors prior to the implementation of the ADLIFE digital health platforms at the German pilot site. The results of the assessment are then used to derive recommendations for action for the subsequent implementation, and for evaluation of the other pilot sites. Methods: Qualitative interviews with healthcare professionals and IT experts were conducted at the German pilot site. The interviews followed a semi-structured interview guideline, based on the HOT-fit framework, focusing on organizational, technological, and human factors. All interviews were audio recorded, transcribed, and subsequently analysed following qualitative content analysis. Results: The results of the 18 interviews show the interviewees’ high openness and motivation to use new innovative digital solutions, as well as an apparent willingness of cooperation between different healthcare professionals. Challenges include limited technical infrastructure and large variability of software to record health data, lacking standards and interfaces. Conclusions: Considering contextual factors on different levels is critical for the success of implementing innovations in healthcare and the transfer into other settings. In our study, the HOT-fit framework proved suitable for assessing contextual factors, when implementing IT innovations in healthcare. In a next step, the methodological approach will be transferred to the six other European pilot sites, participating in the project, for a cross-national assessment of contextual factors.

Assessment of disease burden and drug efficacy is achieved preclinically using high resolution micro computed tomography (CT). However, micro-CT is not applicable to clinical human imaging due to operating at high dose. In addition, the technology differences between micro-CT and standard clinical CT prevent direct translation of preclinical applications. The current proof-of-concept study presents spectral photon-counting CT as a clinically translatable, molecular imaging tool by assessing contrast uptake in an ex-vivo mouse model of pulmonary tuberculosis (TB). Iodine, a common contrast used in clinical CT imaging, was introduced into a murine model of TB. The excised mouse lungs were imaged using a standard micro-CT subsystem (SuperArgus) and the contrast enhanced TB lesions quantified. The same lungs were imaged using a spectral photoncounting CT system (MARS small-bore scanner). Iodine and soft tissues (water and lipid) were materially separated, and iodine uptake quantified. The volume of the TB infection quantified by spectral CT and micro-CT was found to be 2.96 mm ³ and 2.83 mm ³ , respectively. This proof-of-concept study showed that spectral photon-counting CT could be used as a predictive preclinical imaging tool for the purpose of facilitating drug discovery and development. Also, as this imaging modality is available for human trials, all applications are translatable to human imaging. In conclusion, spectral photon-counting CT could accelerate a deeper understanding of infectious lung diseases using targeted pharmaceuticals and intrinsic markers, and ultimately improve the efficacy of therapies by measuring drug delivery and response to treatment in animal models and later in humans.

Healthcare has shifted from paternalistic model of care to patient-centered care where shared decision making is key. The need to share and manage contributions and expertise of different healthcare professionals underlines the relevance of collaborative knowledge management (CKM). However, CKM in healthcare requires one to understand the complexities in integrating multiple aspects of care and the challenges associated with interdisciplinary collaboration and knowledge sharing among healthcare providers. In this study, we use a system modeling approach to understand the complexities in collaborative management of knowledge on advance care planning for multi-morbid patients, within personalized integrated care. To achieve this, focus group discussions (FGD) with 11 participants from Basque Public Health System (Osakidetza) in Spain were involved in identifying the key challenges and developing a systemic thinking model. As a result, three key challenges were identified, i.e., (1) culture, where citizens are not willing to talk about death; (2) healthcare professionals, whose attitude and perspectives need to change; and (3) the current system, that has to change its care model towards a holistic and a shared care model. From the developed causal loop diagrams (CLDs), it is noted that perpetuation of fragmented and paternalistic care is likely to get worse without recognition of the advance care plan (ACP) as a social need and as a crucial part of the clinical practice change.