Despite the development of computer vision techniques, the micro-expression (ME) recognition task still remains a great challenge because MEs have very low intensity and short duration. However, the ME recognition is of great significance since it provides important clues for real affective states detection. This paper proposes a novel Block Division Convolutional Network (BDCNN) with the implicit deep features augmentation. In detail, BDCNN learns from four optical flow features computed by the onset and apex frames of each video. It innovatively divides each image into a set of small blocks in the deep learning model, then the convolution and pooling operations are performed on these small blocks in sequence. To handle the small sample size problem in the micro-expression data, this study uses the improved implicit semantic data augmentation algorithm in the deep features space. Experiments are conducted on three publicly available databases, viz, CASME II, SMIC, and SAMM. Experimental results show that our model outperforms the state-of-the-art methods by attaining the accuracy of 84.32% and F1-score of 82.13% on the 3-class datasets, and the accuracy of 81.82% and F1-score of 75.46% on the 5-class datasets, respectively. Our source code is publicly available for non-commercial or research use at https://github.com/MLDMXM2017/BDCNN.

Motivation: Polypharmacy is the combined use of drugs for the treatment of diseases. However, it often shows a high risk of side effects. Due to unnecessary interactions of combined drugs, the side effects of polypharmacy increase the risk of disease and even lead to death. Thus, obtaining abundant and comprehensive information on the side effects of polypharmacy is a vital task in the healthcare industry. Early traditional methods used machine learning techniques to predict side effects. However, they often make costly efforts to extract features of drugs for prediction. Later, several methods based on knowledge graphs are proposed. They are reported to outperform traditional methods. However, they still show limited performance by failing to model complex relations of side effects among drugs. Results: To resolve the above problems, we propose a novel model by further incorporating complex relations of side effects into knowledge graph embeddings. Our model can translate and transmit multidirectional semantics with fewer parameters, leading to better scalability in large-scale knowledge graphs. Experimental evaluation shows that our model outperforms state-of-the-art models in terms of the average area under the ROC and precision–recall curves. Availability and implementation: Code and data are available at: https://github.com/galaxysunwen/MSTE-master.

Intensity inhomogeneity occurs in many medical images, especially in vessel images. Overcoming the difficulty due to image inhomogeneity is crucial for the segmentation of vessel image. This paper proposes a localized hybrid level-set method for the segmentation of 3D vessel image. The proposed method integrates both local region information and boundary information for vessel segmentation, which is essential for the accurate extraction of tiny vessel structures. The local intensity information is firstly embedded into a region-based contour model, and then incorporated into the level-set formulation of the geodesic active contour model. Compared with the preset global threshold based method, the use of automatically calculated local thresholds enables the extraction of the local image information, which is essential for the segmentation of vessel images. Experiments carried out on the segmentation of 3D vessel images demonstrate the strengths of using locally specified dynamic thresholds in our level-set method. Furthermore, both qualitative comparison and quantitative validations have been performed to evaluate the effectiveness of our proposed model. Experimental results and validations demonstrate that our proposed model can achieve more promising segmentation results than the original hybrid method does.