In this paper, a machine learning-based simulation framework of general-purpose multibody dynamics is introduced. The aim of the framework is to generate a well-trained meta-model of multibody dynamics (MBD) systems. To this end, deep neural network (DNN) is employed to the framework so as to construct data-based meta-model representing multibody systems. Constructing well-defined training data set with time variable is essential to get accurate and reliable motion data such as displacement, velocity, acceleration, and forces. As a result of the introduced approach, the meta-model provides motion estimation of system dynamics without solving the analytical equations of motion. The performance of the proposed DNN meta-modeling was evaluated to represent several MBD systems.