Local Interpretable Model-Agnostic Explanations (LIME) is a popular technique used to increase the interpretability and explainability of black box Machine Learning (ML) algorithms. LIME typically creates an explanation for a single prediction by any ML model by learning a simpler interpretable model (e.g., linear classifier) around the prediction through generating simulated data around the instance by random perturbation, and obtaining feature importance through applying some form of feature selection. While LIME and similar local algorithms have gained popularity due to their simplicity, the random perturbation methods result in shifts in data and instability in the generated explanations, where for the same prediction, different explanations can be generated. These are critical issues that can prevent deployment of LIME in sensitive domains. We propose a deterministic version of LIME. Instead of random perturbation, we utilize Agglomerative Hierarchical Clustering (AHC) to group the training data together and K-Nearest Neighbour (KNN) to select the relevant cluster of the new instance that is being explained. After finding the relevant cluster, a simple model (i.e., linear model or decision tree) is trained over the selected cluster to generate the explanations. Experimental results on six public (three binary and three multi-class) and six synthetic datasets show the superiority for Deterministic Local Interpretable Model-Agnostic Explanations (DLIME), where we quantitatively determine the stability and faithfulness of DLIME compared to LIME.

Detection of Alzheimer’s Disease (AD) from neuroimaging data such as MRI through machine learning has been a subject of intense research in recent years. Recent success of deep learning in computer vision has progressed such research further. However, common limitations with such algorithms are reliance on a large number of training images, and requirement of careful optimization of the architecture of deep networks. In this paper, we attempt solving these issues with transfer learning, where the state-of-the-art VGG architecture is initialized with pre-trained weights from large benchmark datasets consisting of natural images. The network is then fine-tuned with layer-wise tuning, where only a pre-defined group of layers are trained on MRI images. To shrink the training data size, we employ image entropy to select the most informative slices. Through experimentation on the ADNI dataset, we show that with training size of 10 to 20 times smaller than the other contemporary methods, we reach state-of-the-art performance in AD vs. NC, AD vs. MCI, and MCI vs. NC classification problems, with a 4% and a 7% increase in accuracy over the state-of-the-art for AD vs. MCI and MCI vs. NC, respectively. We also provide detailed analysis of the effect of the intelligent training data selection method, changing the training size, and changing the number of layers to be fine-tuned. Finally, we provide Class Activation Maps (CAM) that demonstrate how the proposed model focuses on discriminative image regions that are neuropathologically relevant, and can help the healthcare practitioner in interpreting the model’s decision making process.

Electrocardiogram (ECG) is an authoritative source to diagnose and counter critical cardiovascular syndromes such as arrhythmia and myocardial infarction (MI). Current machine learning techniques either depend on manually extracted features or large and complex deep learning networks which merely utilize the 1D ECG signal directly. Since intelligent multimodal fusion can perform at the state-of-the-art level with an efficient deep network, therefore, in this paper, we propose two computationally efficient multimodal fusion frameworks for ECG heart beat classification called Multimodal Image Fusion (MIF) and Multimodal Feature Fusion (MFF). At the input of these frameworks, we convert the raw ECG data into three different images using Gramian Angular Field (GAF), Recurrence Plot (RP) and Markov Transition Field (MTF). In MIF, we first perform image fusion by combining three imaging modalities to create a single image modality which serves as input to the Convolutional Neural Network (CNN). In MFF, we extracted features from penultimate layer of CNNs and fused them to get unique and interdependent information necessary for better performance of classifier. These informational features are finally used to train a Support Vector Machine (SVM) classifier for ECG heart-beat classification. We demonstrate the superiority of the proposed fusion models by performing experiments on PhysioNet's MIT-BIH dataset for five distinct conditions of arrhythmias which are consistent with the AAMI EC57 protocols and on PTB diagnostics dataset for Myocardial Infarction (MI) classification. We achieved classification accuracy of 99.7% and 99.2% on arrhythmia and MI classification, respectively. Source code at https://github.com/zaamad/ECG-Heartbeat-Classification-Using-Multimodal-Fusion.

Physiological signals are the most reliable form of signals for emotion recognition, as they cannot be controlled deliberately by the subject. Existing review papers on emotion recognition based on physiological signals surveyed only the regular steps involved in the workflow of emotion recognition such as pre-processing, feature extraction, and classification. While these are important steps, such steps are required for any signal processing application. Emotion recognition poses its own set of challenges that are very important to address for a robust system. Thus, to bridge the gap in the existing literature, in this paper, we review the effect of inter-subject data variance on emotion recognition, important data annotation techniques for emotion recognition and their comparison, data pre-processing techniques for each physiological signal, data splitting techniques for improving the generalization of emotion recognition models and different multimodal fusion techniques and their comparison. Finally, we discuss key challenges and future directions in this field.