Alec Redwood

Dr. Alec Redwood

orcid

Research Focus & Metrics

Academic Career Length

26Years (2001-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2018 in The Journal of Allergy and Clinical Immunology: In Practice
Verified
Journal Article
Closed access
KWKatie D. White
Katie D. White
RARiichiro Abe
Riichiro Abe
MAMichael Ardern-Jones
Michael Ardern-Jones
TBThomas Beachkofsky
Thomas Beachkofsky
CBCharles Bouchard
Charles Bouchard
EPElizabeth J. Phillips
Elizabeth J. Phillips

1 July 2019 in Journal of Allergy and Clinical Immunology
Verified
Journal Article
Closed access
KKKatherine C. Konvinse
Katherine C. Konvinse
JTJason A. Trubiano
Jason A. Trubiano
RPRebecca Pavlos
Rebecca Pavlos
IJIan James
Ian James
CSChristian M. Shaffer
Christian M. Shaffer
EPElizabeth J. Phillips
Elizabeth J. Phillips

25 May 2016 in Mucosal Immunology
Verified
Journal Article
Open access
PDF file
KMKaitlyn Morabito
Kaitlyn Morabito
TRT.R. Ruckwardt
T.R. Ruckwardt
ARAlec Redwood
Alec Redwood
SMS.M. Moin
S.M. Moin
DPD.A. Price
D.A. Price
BGB.S. Graham
B.S. Graham
Cytomegalovirus vectors are promising delivery vehicles for vaccine strategies that aim to elicit effector CD8+ T cells. To determine how the route of immunization affects CD8+ T-cell responses in the lungs of mice vaccinated with a murine cytomegalovirus vector expressing the respiratory syncytial virus matrix (M) protein, we infected CB6F1 mice via the intranasal or intraperitoneal route and evaluated the M-specific CD8+ T-cell response at early and late time points. We found that intranasal vaccination generated robust and durable tissue-resident effector and effector memory CD8+ T-cell populations that were undetectable after intraperitoneal vaccination. The generation of these antigen-experienced cells by intranasal vaccination resulted in earlier T-cell responses, interferon gamma secretion, and viral clearance after respiratory syncytial virus challenge. Collectively, these findings validate a novel approach to vaccination that emphasizes the route of delivery as a key determinant of immune priming at the site of vulnerability.

31 October 2023 in Nature Reviews Clinical Oncology
Verified
Journal Article
Closed access
PDF file
VAVenkateswar Addala
Venkateswar Addala
FNFelicity Newell
Felicity Newell
JPJohn V. Pearson
John V. Pearson
ARAlec Redwood
Alec Redwood
BRBruce W. Robinson
Bruce W. Robinson
Nic WaddellNic Waddell
Nic Waddell

24 November 2017 in HLA
Verified
Journal Article
Closed access
PDF file
ARAlec Redwood
Alec Redwood
RPR. K. Pavlos
R. K. Pavlos
KWK. D. White
K. D. White
EPElizabeth J. Phillips
Elizabeth J. Phillips

27 December 2017 in Journal of Experimental Medicine
Verified
Journal Article
Open access
ADArnaud Delpoux
Arnaud Delpoux
RMRodrigo Hess Michelini
Rodrigo Hess Michelini
SVShilpi Verma
Shilpi Verma
CLChen-Yen Lai
Chen-Yen Lai
KOKyla D. Omilusik
Kyla D. Omilusik
SHStephen M. Hedrick
Stephen M. Hedrick
Upon infection with an intracellular pathogen, cytotoxic CD8+ T cells develop diverse differentiation states characterized by function, localization, longevity, and the capacity for self-renewal. The program of differentiation is determined, in part, by FOXO1, a transcription factor known to integrate extrinsic input in order to specify survival, DNA repair, self-renewal, and proliferation. At issue is whether the state of T cell differentiation is specified by initial conditions of activation or is actively maintained. To study the spectrum of T cell differentiation, we have analyzed an infection with mouse cytomegalovirus, a persistent-latent virus that elicits different cytotoxic T cell responses characterized as acute resolving or inflationary. Our results show that FOXO1 is continuously required for all the phenotypic characteristics of memory-effector T cells such that with acute inactivation of the gene encoding FOXO1, T cells revert to a short-lived effector phenotype, exhibit reduced viability, and manifest characteristics of anergy.