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Puxian Fang
Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China

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Review
Published: 13 June 2021 in Viruses
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Coronavirus accessory proteins are a unique set of proteins whose genes are interspersed among or within the genes encoding structural proteins. Different coronavirus genera, or even different species within the same coronavirus genus, encode varying amounts of accessory proteins, leading to genus- or species-specificity. Though accessory proteins are dispensable for the replication of coronavirus in vitro, they play important roles in regulating innate immunity, viral proliferation, and pathogenicity. The function of accessory proteins on virus infection and pathogenesis is an area of particular interest. In this review, we summarize the current knowledge on accessory proteins of several representative coronaviruses that infect humans or animals, including the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with an emphasis on their roles in interaction between virus and host, mainly involving stress response, innate immunity, autophagy, and apoptosis. The cross-talking among these pathways is also discussed.

ACS Style

Puxian Fang; Liurong Fang; Huichang Zhang; Sijin Xia; Shaobo Xiao. Functions of Coronavirus Accessory Proteins: Overview of the State of the Art. Viruses 2021, 13, 1139 .

AMA Style

Puxian Fang, Liurong Fang, Huichang Zhang, Sijin Xia, Shaobo Xiao. Functions of Coronavirus Accessory Proteins: Overview of the State of the Art. Viruses. 2021; 13 (6):1139.

Chicago/Turabian Style

Puxian Fang; Liurong Fang; Huichang Zhang; Sijin Xia; Shaobo Xiao. 2021. "Functions of Coronavirus Accessory Proteins: Overview of the State of the Art." Viruses 13, no. 6: 1139.