In the realm of urban geotechnical infrastructure development, accurate estimation of the California Bearing Ratio (CBR), a key indicator of the strength of unbound granular material and subgrade soil, is paramount for pavement design. Traditional laboratory methods for obtaining CBR values are time-consuming and labor-intensive, prompting the exploration of novel computational strategies. This paper illustrates the development and application of machine learning techniques—multivariate linear regression (MLR), artificial neural networks (ANN), and the adaptive neuro-fuzzy inference system (ANFIS)—to indirectly predict the CBR based on the soil type, plasticity index (PI), and maximum dry density (MDD). Our study analyzed 2191 soil samples for parameters including PI, MDD, particle size distribution, and CBR, leveraging theoretical calculations and big data analysis. The ANFIS demonstrated superior performance in CBR prediction with an R² value of 0.81, surpassing both MLR and ANN. Sensitivity analysis revealed the PI as the most significant parameter affecting the CBR, carrying a relative importance of 46%. The findings underscore the potent potential of machine learning and neuro-fuzzy inference systems in the sustainable management of non-renewable urban resources and provide crucial insights for urban planning, construction materials selection, and infrastructure development. This study bridges the gap between computational techniques and geotechnical engineering, heralding a new era of intelligent urban resource management.