Wound healing is a significant problem in clinical management. Various functional dressings are studied to promote wound healing through biochemical factors. They are generally expensive, complex to fabricate, and may adversely affect the wound. Mechanical forces are the critical regulators of tissue repair. Although contraction is shown to promote wound healing, the underlying mechanisms are not fully understood. In this study, a novel adhesive temperature‐sensitive mechanically active hydrogel with a simple and inexpensive preparation process is developed. The dressing is able to adhere to the wound surface and actively contract the wound in response to body temperature. This mechanical contraction enhances the proliferative activity of basal cells, reduces the inflammatory response of the wound, and promotes wound healing. Furthermore, RNA‐seq clarifies how the gene regulatory network is regulated by contraction. Finally, using pharmacological inhibitors, YAP and MEK are identified as the key signaling molecules for contraction‐mediated tissue healing in vivo.

Research on liposome-composite hydrogel microspheres (LHMs) drug delivery systems, primarily composed of drugs, liposomes, and hydrogels, has garnered growing scientific interest.

Intestinal obstruction is a common complication caused by colorectal cancer, and the implantation of stents has become an indispensable palliative treatment strategy for non‐surgical eligible patients. However, the lack of sustained anti‐tumor efficacy and wear caused by configuration or deformation discrepancies has led to the recurrence of stenosis, posing a significant challenge in clinical treatment. Here, we reported an intestine‐specific, application‐driven 4D‐printed sandwich‐structured metamaterial intestinal stent platform, achieving the triple goals of sustained anti‐tumor effects, customized configuration and performance, and rapid relief of intestinal obstruction. Specifically, the platform comprised an outer Janus layer designed for synergistic photothermal‐and‐drug anti‐tumor effects, an intermediate layer of biomimetic gradient metamaterials for structural support and coordinated deformation, and a hydrophobic inner layer to mitigate the risk of restenosis. Overall, this study presented a multifunctional intestinal stent built upon a scalable design paradigm, offering an innovative and clinically translatable therapeutic strategy for personalized colorectal cancer management.