Professor of Clinical Pathology at the Department of Experimental Medicine of the Sapienza University of Rome, where he directs the System Biology Group Laboratory. He is a professor of Biophysics within the PhD course in Morphogenesis and Tissue Engineering. He also directs the «Aristide Scano» Space Biomedicine Laboratory. Author of over 190 scientific publications, he has published numerous specialist textbooks (The New Alchemists: The Risks of Genetic Manipulations, Oxford WIT Press, 2012; Systems Biology, Springer 2017; Network-based Pharmacology and Personalized Systems Approach in Biomedicine, Springer 2019; Clinical Interpretation of Laboratory Tests, Piccin, 2020; Systems Biology: Methods and Protocols, Springer, 2023). He has been a visiting professor at TUFT universities in Boston, KSU in Saudi Arabia, and the Polytechnic Institute of Tomsk and Perm (Siberia, Russia). He was a member of the Scientific Technical Council of the Italian Space Agency (ASI) from 2005 to 2014, also holding the role of President of the Committee. He was among the founders of the Italian Society for Space Biomedicine and Biotechnology (ISSBB). He is currently coordinator of the technical table of the Interministerial Committee for policies relating to space and aerospace research (COMINT). He is on the Board of the Aerospace Research Center of La Sapienza University (CRAS) since 2009. He has been elected member of the Polish Academy of Sciences Nicholas Copernicus in 2021.