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Whilst the importance of keratinocytes as a first-line defense has been widely investigated, little is known about their interactions with non-resident immune cells. In this study, the impact of human keratinocytes on T cell effector functions was analyzed in an antigen-specific in vitro model of allergic contact dermatitis (ACD) to nickel sulfate. Keratinocytes partially inhibited T cell proliferation and cytokine production. This effect was dependent on the keratinocyte/T cell ratio and was partially reversible by increasing the number of autologous dendritic cells. The inhibition of T cell proliferation by keratinocytes was independent of the T cell subtype and antigen presentation by different professional antigen-presenting cells. Autologous and heterologous keratinocytes showed comparable effects, while the fixation of keratinocytes with paraformaldehyde abrogated the immunosuppressive effect. The separation of keratinocytes and T cells by a transwell chamber, as well as a cell-free keratinocyte supernatant, inhibited T cell effector functions to the same amount as directly co-cultured keratinocytes, thus proving that soluble factor/s account for the observed suppressive effects. In conclusion, keratinocytes critically control the threshold of inflammatory processes in the skin by inhibiting T cell proliferation and cytokine production.
Peter Seiringer; Stefanie Eyerich; Kilian Eyerich; Daniela Dittlein; Anna Pilz; Emanuele Scala; Johannes Ring; Heidrun Behrendt; Andrea Cavani; Claudia Traidl-Hoffmann. Keratinocytes Regulate the Threshold of Inflammation by Inhibiting T Cell Effector Functions. Cells 2021, 10, 1606 .
AMA StylePeter Seiringer, Stefanie Eyerich, Kilian Eyerich, Daniela Dittlein, Anna Pilz, Emanuele Scala, Johannes Ring, Heidrun Behrendt, Andrea Cavani, Claudia Traidl-Hoffmann. Keratinocytes Regulate the Threshold of Inflammation by Inhibiting T Cell Effector Functions. Cells. 2021; 10 (7):1606.
Chicago/Turabian StylePeter Seiringer; Stefanie Eyerich; Kilian Eyerich; Daniela Dittlein; Anna Pilz; Emanuele Scala; Johannes Ring; Heidrun Behrendt; Andrea Cavani; Claudia Traidl-Hoffmann. 2021. "Keratinocytes Regulate the Threshold of Inflammation by Inhibiting T Cell Effector Functions." Cells 10, no. 7: 1606.
Irritant contact dermatitis is the consequence of direct toxic effects of chemical or physical stimuli contacting the skin and perturbing skin homeostasis. Acute or repeated exposure to irritants determines the activation of the innate immune system with the release of pro-inflammatory cytokines and chemokines by keratinocytes and other skin resident cells. The local release of IL-1α, IL-1β, TNF-α and IL-6 activates endothelial cells and promotes the recruitment of migrating cells, such as neutrophils, monocytes and T lymphocytes that are involved in the amplification of the inflammatory reaction. Susceptibility to develop an irritant contact dermatitis depends on several intrinsic factors which ranges from the age and sex of the individual, to the integrity of the skin barrier, and, finally, to the genetic polymorphism in cytokine genes.
Valentina DiMartino; Fernanda Scopelliti; Concetta Mirisola; Andrea Cavani. Mechanisms in Irritant Contact Dermatitis. Clinical Contact Dermatitis 2021, 37 -40.
AMA StyleValentina DiMartino, Fernanda Scopelliti, Concetta Mirisola, Andrea Cavani. Mechanisms in Irritant Contact Dermatitis. Clinical Contact Dermatitis. 2021; ():37-40.
Chicago/Turabian StyleValentina DiMartino; Fernanda Scopelliti; Concetta Mirisola; Andrea Cavani. 2021. "Mechanisms in Irritant Contact Dermatitis." Clinical Contact Dermatitis , no. : 37-40.
Allergic Contact Dermatitis is the consequence of a dysregulated immune response to chemically reactive small molecules, the haptens, penetrating the skin. In the sensitization phase, haptens activate the innate immune system by interacting with pattern recognition receptors, such as Toll like receptors, expressed by skin resident cells, thus initiating a cascade of events leading to the maturation and mobilization of skin dendritic cells. Maturing dendritic cells leave the skin and carry the newly formed hapten epitopes to regional lymph nodes, where they expand a variety of hapten-specific T lymphocytes with the capacity to recirculate in the skin environment. Expression of allergic contact dermatitis is mostly dependent on the recruitment at the site of hapten challenge of hapten-specific CD4+ and CD8+ T cells that, once activated, release pro-inflammatory cytokines and induce the apoptosis of keratinocytes. Contact sensitization is negatively regulated through several mechanisms, including specialized subsets of T regulatory cells, B cells and IL-10-releasing NKT cells, that are both responsible for the development of specific immune tolerance in non-allergic individuals, and limit the magnitude of the inflammatory response during allergic contact dermatitis reactions.
Fernanda Scopelliti; Valentina DiMartino; Caterina Cattani; Andrea Cavani. Mechanisms in Allergic Contact Dermatitis. Clinical Contact Dermatitis 2021, 41 -48.
AMA StyleFernanda Scopelliti, Valentina DiMartino, Caterina Cattani, Andrea Cavani. Mechanisms in Allergic Contact Dermatitis. Clinical Contact Dermatitis. 2021; ():41-48.
Chicago/Turabian StyleFernanda Scopelliti; Valentina DiMartino; Caterina Cattani; Andrea Cavani. 2021. "Mechanisms in Allergic Contact Dermatitis." Clinical Contact Dermatitis , no. : 41-48.
Immigrants show higher adjusted diabetes prevalence than Italians, especially among South-East Asians followed by North and Sub-Saharan Africans. Diabetes progression is influenced by food behaviors, and diet control is a critical aspect in disease management. Food habits have many cultural and symbolic implications. Guidelines recommend that every patient should receive appropriate self-management education according to cultural and socioeconomic characteristics. This study aims to test whether a customized diet and transcultural mediator’s support can improve immigrants’ food habits. A pre-post quali-quantitative study was conducted among 20–79-year-old Bangladeshi and North African diabetic immigrants. The INMP transcultural mediator, an expert in the social and health care field, actively participates in clinical activity by decoding linguistic and cultural needs expressed by the foreigner patient. Five culturally tailored dietary profiles were designed according to international diabetes guidelines and adjusted to traditional food habits. Data were collected with two different semi-structured questionnaires. Changes in food consumption were assessed through McNemar’s test, while paired Wilcoxon Signed-Rank test was used to analyze pre and post intervention. Fifty-five patients were enrolled. At follow-up, cereals, meat, and potatoes intake significantly improved, and the number of adequate dietary habits for each patient increased significantly. Transcultural mediator support was 90% positively evaluated. Adherence to dietary control is favorably influenced by a transcultural intervention, which is based on clinical and socio-cultural criteria, in compliance with patient’s lifestyles.
Laura Piombo; Gianluca Nicolella; Giulia Barbarossa; Claudio Tubili; Mayme Mary Pandolfo; Miriam Castaldo; Gianfranco Costanzo; Concetta Mirisola; Andrea Cavani. Outcomes of Culturally Tailored Dietary Intervention in the North African and Bangladeshi Diabetic Patients in Italy. International Journal of Environmental Research and Public Health 2020, 17, 8932 .
AMA StyleLaura Piombo, Gianluca Nicolella, Giulia Barbarossa, Claudio Tubili, Mayme Mary Pandolfo, Miriam Castaldo, Gianfranco Costanzo, Concetta Mirisola, Andrea Cavani. Outcomes of Culturally Tailored Dietary Intervention in the North African and Bangladeshi Diabetic Patients in Italy. International Journal of Environmental Research and Public Health. 2020; 17 (23):8932.
Chicago/Turabian StyleLaura Piombo; Gianluca Nicolella; Giulia Barbarossa; Claudio Tubili; Mayme Mary Pandolfo; Miriam Castaldo; Gianfranco Costanzo; Concetta Mirisola; Andrea Cavani. 2020. "Outcomes of Culturally Tailored Dietary Intervention in the North African and Bangladeshi Diabetic Patients in Italy." International Journal of Environmental Research and Public Health 17, no. 23: 8932.
Objective Our study aimed at addressing the prevalence of infectious diseases in a population of unaccompanied immigrant minors living in reception centers of Rome, Italy. Methods The study was carried out from January 2013-January 2019. All unaccompanied immigrant minors were screened for hepatitis B (HBV), hepatitis C (HCV), syphilis and latent tuberculosis infection. Results A total of 879 unaccompanied immigrant minors, 858 males and 21 females, aged 13-18 years old, were studied. Out of these, 615 were from Africa, 179 from Asia and 84 from Eastern Europe. We observed a low prevalence of HBsAg carriage (2.5%) and very low prevalence of HCV (0.72%), latent syphilis (0.4%), latent tuberculosis, defined as TST+ x-ray- case, was diagnosed in 102 (12%) minors. Conclusions Similarly to previous studies, our data demonstrate that migrant minors are generally healthy. However, given the relatively high prevalence of hepatitis B and latent TB, a systematic screening for these diseases among immigrant minors immigrants is highly recommended for early detection and treatment of potentially transmissible diseases.
Rosalia Marrone; Giovanni Baglio; Giusy Bruscino; Gianfranco Costanzo; Andrea Cavani; Concetta Mirisola. Prevalence of latent tuberculosis infection, hepatitis B, hepatitis C, and syphilis among newly arrived unaccompanied minors living in reception centers in Rome. International Journal of Infectious Diseases 2020, 101, 126 -130.
AMA StyleRosalia Marrone, Giovanni Baglio, Giusy Bruscino, Gianfranco Costanzo, Andrea Cavani, Concetta Mirisola. Prevalence of latent tuberculosis infection, hepatitis B, hepatitis C, and syphilis among newly arrived unaccompanied minors living in reception centers in Rome. International Journal of Infectious Diseases. 2020; 101 ():126-130.
Chicago/Turabian StyleRosalia Marrone; Giovanni Baglio; Giusy Bruscino; Gianfranco Costanzo; Andrea Cavani; Concetta Mirisola. 2020. "Prevalence of latent tuberculosis infection, hepatitis B, hepatitis C, and syphilis among newly arrived unaccompanied minors living in reception centers in Rome." International Journal of Infectious Diseases 101, no. : 126-130.
In many contexts, individuals with lower socioeconomic status, especially immigrants, have a higher burden of negative alcohol-related consequences and a higher probability of receiving a psychiatric diagnosis. This study aimed at exploring sociodemographic and clinical characteristics associated with harmful use of alcohol (HUA) among immigrant patients. A cross-sectional study was conducted in Rome (Italy) on a sample of 330 immigrant patients admitted to the gastroenterology outpatient clinic of the INMP (March 2013–October 2014). HUA was evaluated through the Alcohol Use Disorders Identification Test (AUDIT) questionnaire. The presence of psychiatric disorders was diagnosed through SCID I–II interviews. The association between sociodemographic characteristics and psychiatric disorders and HUA was evaluated through a multivariate log-binomial regression model. HUA was associated with unemployment, longer stay in Italy, mood disorder and not being married, especially among African immigrants. We provide original findings about a selected, hard-to-investigate population, suggesting priorities in interventions on HUA among specific vulnerable subgroups.
Anteo Di Napoli; Teresa Morgillo; Alessandra Rossi; Martina Ventura; Lorenzo Nosotti; Andrea Cavani; Gianfranco Costanzo; Concetta Mirisola; Alessio Petrelli. Sociodemographic Characteristics Associated with Harmful Use of Alcohol Among Economically and Socially Disadvantaged Immigrant Patients in Italy. Journal of Immigrant and Minority Health 2019, 22, 426 -431.
AMA StyleAnteo Di Napoli, Teresa Morgillo, Alessandra Rossi, Martina Ventura, Lorenzo Nosotti, Andrea Cavani, Gianfranco Costanzo, Concetta Mirisola, Alessio Petrelli. Sociodemographic Characteristics Associated with Harmful Use of Alcohol Among Economically and Socially Disadvantaged Immigrant Patients in Italy. Journal of Immigrant and Minority Health. 2019; 22 (2):426-431.
Chicago/Turabian StyleAnteo Di Napoli; Teresa Morgillo; Alessandra Rossi; Martina Ventura; Lorenzo Nosotti; Andrea Cavani; Gianfranco Costanzo; Concetta Mirisola; Alessio Petrelli. 2019. "Sociodemographic Characteristics Associated with Harmful Use of Alcohol Among Economically and Socially Disadvantaged Immigrant Patients in Italy." Journal of Immigrant and Minority Health 22, no. 2: 426-431.