Authors’ contributions: Conceived and designed the study: Hsin-Lun Lee MD and Yi-Chieh Tsai MD. Performed the experiments: Narpati Wesa Pikatan MD, PhD. Analyzed the data: Vijesh Kumar Yadav PhD. Bioinformatics: Chi-Tai Yeh Ph.D. Wrote the manuscript: Ming-Yao Chen MD and Chi-Tai Yeh MD, PhD. Provided reagents, materials, experimental infrastructure, and administrative oversight: Jo-Ting Tsai MD, PhD. All authors read and approved the final version of the manuscript. All authors read and approved the final manuscript.