Zongming Song

Dr. Zongming Song

orcid

Research Focus & Metrics

Academic Career Length

13Years (2014-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 July 2015 in International Journal of Pharmaceutics
Verified
Journal Article
Closed access
BXBinbin Xie
Binbin Xie
LJLing Jin
Ling Jin
ZLZichao Luo
Zichao Luo
JYJing Yu
Jing Yu
SSShuai Shi
Shuai Shi
ZSZongming Song
Zongming Song

18 March 2020 in Acta Ophthalmologica
Verified
Journal Article
Open access
PDF file
HQHuiling Qing
Huiling Qing
ZLZhijie Li
Zhijie Li
ZYZhengwei Yang
Zhengwei Yang
MSMenghai Shi
Menghai Shi
ZHZixu Huang
Zixu Huang
ZSZongming Song
Zongming Song
Click on the book chapter title to read more.

1 November 2016 in International Journal of Pharmaceutics
Verified
Journal Article
Closed access
WWWei Wu
Wei Wu
ZHZhifen He
Zhifen He
ZZZhaoliang Zhang
Zhaoliang Zhang
XYXinxin Yu
Xinxin Yu
ZSZongming Song
Zongming Song
XLXing yi Li
Xing yi Li

10 January 2018 in Biotechnology Journal
Verified
Journal Article
Closed access
PDF file
HXHaihua Xie
Haihua Xie
LTLianchao Tang
Lianchao Tang
XHXiubin He
Xiubin He
XLXiexie Liu
Xiexie Liu
CZChenchen Zhou
Chenchen Zhou
FGFeng Gu
Feng Gu

8 October 2021 in Nature Communications
Verified
Journal Article
Open access
PDF file
JFJunhao Fu
Junhao Fu
QLQing Li
Qing Li
XLXiaoyu Liu
Xiaoyu Liu
TTTianxiang Tu
Tianxiang Tu
XLXiujuan Lv
Xiujuan Lv
FGFeng Gu
Feng Gu
Adenine base editors (ABE) are genome-editing tools that have been harnessed to introduce precise A•T to G•C conversion. However, the low activity of ABE at certain sites remains a major bottleneck that precludes efficacious applications. Here, to address it, we develop a directional screening system in human cells to evolve the deaminase component of the ABE, and identify three high-activity NG-ABEmax variants: NG-ABEmax-SGK (R101S/D139G/E140K), NG-ABEmax-R (Q154R) and NG-ABEmax-K (N127K). With further engineering, we create a consolidated variant [NG-ABEmax-KR (N127K/Q154R)] which exhibit superior editing activity both in human cells and in mouse disease models, compared to the original NG-ABEmax. We also find that NG-ABEmax-KR efficiently introduce natural mutations in gamma globin gene promoters with more than four-fold increase in editing activity. This work provides a broadly applicable, rapidly deployable platform to directionally screen and evolve user-specified traits in base editors that extend beyond augmented editing activity.

1 August 2022 in Eye
Verified
Journal Article
Closed access
PDF file
XHXumeng Hu
Xumeng Hu
BZBeibei Zhang
Beibei Zhang
XLXiaoli Li
Xiaoli Li
MLMiao Li
Miao Li
YWYange Wang
Yange Wang
ZSZongming Song
Zongming Song