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Yuanyuan Guo

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Journal article
Published: 26 August 2021 in Electrochem
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Electrochemistry represents an important analytical technique used to acquire and assess chemical information in detail, which can aid fundamental investigations in various fields, such as biological studies. For example, electrochemistry can be used as simple and cost-effective means for bio-marker tracing in applications, such as health monitoring and food security screening. In combination with light, powerful spatially-resolved applications in both the investigation and manipulation of biochemical reactions begin to unfold. In this article, we focus primarily on light-addressable electrochemistry based on semiconductor materials and light-readable electrochemistry enabled by electrochemiluminescence (ECL). In addition, the emergence of multiplexed and imaging applications will also be introduced.

ACS Style

Hiroya Abe; Tomoki Iwama; Yuanyuan Guo. Light in Electrochemistry. Electrochem 2021, 2, 472 -489.

AMA Style

Hiroya Abe, Tomoki Iwama, Yuanyuan Guo. Light in Electrochemistry. Electrochem. 2021; 2 (3):472-489.

Chicago/Turabian Style

Hiroya Abe; Tomoki Iwama; Yuanyuan Guo. 2021. "Light in Electrochemistry." Electrochem 2, no. 3: 472-489.

Journal article
Published: 28 November 2020 in Biosensors and Bioelectronics
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Correlating in-brain pH fluctuations with the pathophysiology has been impeded by the lack of in vivo techniques to precisely determine local pH changes. Here, we developed an all-in-one pH probe for spatially-resolved and label-free pH sensing in vivo, based on a field-effect pH sensor, i.e., a light-addressable potentiometric sensor (LAPS), coupled to a flexible multimodal fiber. A readout photocurrent from the LAPS, elicited from a modulated light source, registers the localized surface potential change, proportional to the pH change. Upon simultaneous illuminations at multi-spot by a plurality of light sources with different modulation frequencies, pH changes at multiple designated spots are obtained via demultiplexing this photocurrent. To enable its in vivo applications, we combined the LAPS with a multimodal fiber fabricated by the convergence thermal drawing. Such fiber seamlessly integrates a multicore optical waveguide in the center for the light delivery, surrounded by electrodes for leading out photocurrent and serving as a pseudo-reference electrode, respectively. Such hybrid all-in-one pH probes can measure pH changes at 14 pixels simultaneously with a spatial resolution of 250 μm and a temporal resolution of 30 Hz. The pH sensitivity was characterized as 57.5 ± 2.2 mV/pH homogeneously across all measurable pixels. Such probes have been implanted into the hippocampal formation of rats and their capabilities to capture pH changes at multiple pixels were evaluated at both physiological and pathological conditions. Technologies developed here represents a new class of in vivo chemical sensing technologies enabling the spatially-resolved investigation of intrinsic chemical signals in deep brain structures with high spatial and temporal resolutions.

ACS Style

Yuanyuan Guo; Carl Frederik Werner; Shoma Handa; Mengyun Wang; Tomokazu Ohshiro; Hajime Mushiake; Tatsuo Yoshinobu. Miniature multiplexed label-free pH probe in vivo. Biosensors and Bioelectronics 2020, 174, 112870 .

AMA Style

Yuanyuan Guo, Carl Frederik Werner, Shoma Handa, Mengyun Wang, Tomokazu Ohshiro, Hajime Mushiake, Tatsuo Yoshinobu. Miniature multiplexed label-free pH probe in vivo. Biosensors and Bioelectronics. 2020; 174 ():112870.

Chicago/Turabian Style

Yuanyuan Guo; Carl Frederik Werner; Shoma Handa; Mengyun Wang; Tomokazu Ohshiro; Hajime Mushiake; Tatsuo Yoshinobu. 2020. "Miniature multiplexed label-free pH probe in vivo." Biosensors and Bioelectronics 174, no. : 112870.

Research article
Published: 24 January 2020 in PLoS ONE
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Electrical recording permits direct readout of neural activity but offers limited ability to correlate it to the network topography. On the other hand, optical imaging reveals the architecture of neural circuits, but relies on bulky optics and fluorescent reporters whose signals are attenuated by the brain tissue. Here we introduce implantable devices to record brain activities based on the field effect, which can be further extended with capability of label-free electrophysiological mapping. Such devices reply on light-addressable potentiometric sensors (LAPS) coupled to polymer fibers with integrated electrodes and optical waveguide bundles. The LAPS utilizes the field effect to convert electrophysiological activity into regional carrier redistribution, and the neural activity is read out in a spatially resolved manner as a photocurrent induced by a modulated light beam. Spatially resolved photocurrent recordings were achieved by illuminating different pixels within the fiber bundles. These devices were applied to record local field potentials in the mouse hippocampus. In conjunction with the raster-scanning via the single modulated beam, this technology may enable fast label-free imaging of neural activity in deep brain regions.

ACS Style

Yuanyuan Guo; Carl F. Werner; Andres Canales; Li Yu; Xiaoting Jia; Polina Anikeeva; Tatsuo Yoshinobu. Polymer-fiber-coupled field-effect sensors for label-free deep brain recordings. PLoS ONE 2020, 15, e0228076 .

AMA Style

Yuanyuan Guo, Carl F. Werner, Andres Canales, Li Yu, Xiaoting Jia, Polina Anikeeva, Tatsuo Yoshinobu. Polymer-fiber-coupled field-effect sensors for label-free deep brain recordings. PLoS ONE. 2020; 15 (1):e0228076.

Chicago/Turabian Style

Yuanyuan Guo; Carl F. Werner; Andres Canales; Li Yu; Xiaoting Jia; Polina Anikeeva; Tatsuo Yoshinobu. 2020. "Polymer-fiber-coupled field-effect sensors for label-free deep brain recordings." PLoS ONE 15, no. 1: e0228076.

Journal article
Published: 21 October 2019 in Sensors
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A light-addressable potentiometric sensor (LAPS) is a chemical sensor with a field-effect structure based on semiconductor. Its response to the analyte concentration is read out in the form of a photocurrent generated by illuminating the semiconductor with a modulated light beam. As stated in its name, a LAPS is capable of spatially resolved measurement using a scanning light beam. Recently, it has been pointed out that a part of the signal current is lost by the return current due to capacitive coupling between the solution and the semiconductor, which may seriously affect the sensor performance such as the signal-to-noise ratio, the spatial resolution, and the sensitivity. In this study, a circuit model for the return current is proposed to study its dependence on various parameters such as the diameter of contact area, the modulation frequency, the specific conductivity of the solution, and the series resistance of the circuit. It is suggested that minimization of the series resistance of the circuit is of utmost importance in order to avoid the influence of the return current. The results of calculation based on this model are compared with experimental results, and its applicability and limitation are discussed.

ACS Style

Tatsuo Yoshinobu; Daisuke Sato; Yuanyuan Guo; Carl Frederik Werner; Ko-Ichiro Miyamoto. Modeling of the Return Current in a Light-Addressable Potentiometric Sensor. Sensors 2019, 19, 4566 .

AMA Style

Tatsuo Yoshinobu, Daisuke Sato, Yuanyuan Guo, Carl Frederik Werner, Ko-Ichiro Miyamoto. Modeling of the Return Current in a Light-Addressable Potentiometric Sensor. Sensors. 2019; 19 (20):4566.

Chicago/Turabian Style

Tatsuo Yoshinobu; Daisuke Sato; Yuanyuan Guo; Carl Frederik Werner; Ko-Ichiro Miyamoto. 2019. "Modeling of the Return Current in a Light-Addressable Potentiometric Sensor." Sensors 19, no. 20: 4566.

Research article
Published: 13 June 2017 in ACS Nano
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Microelectrodes provide a direct pathway to investigate brain activities electrically from the external world, which has advanced our fundamental understanding of brain functions and has been utilized for rehabilitative applications as brain–machine interfaces. However, minimizing the tissue response and prolonging the functional durations of these devices remain challenging. Therefore, the development of next-generation microelectrodes as neural interfaces is actively progressing from traditional inorganic materials toward biocompatible and functional organic materials with a miniature footprint, good flexibility, and reasonable robustness. In this study, we developed a miniaturized all polymer-based neural probe with carbon nanofiber (CNF) composites as recording electrodes via the scalable thermal drawing process. We demonstrated that in situ CNF unidirectional alignment can be achieved during the thermal drawing, which contributes to a drastic improvement of electrical conductivity by 2 orders of magnitude compared to a conventional polymer electrode, while still maintaining the mechanical compliance with brain tissues. The resulting neural probe has a miniature footprint, including a recording site with a reduced size comparable to a single neuron and maintained impedance that was able to capture neural activities. Its stable functionality as a chronic implant has been demonstrated with the long-term reliable electrophysiological recording with single-spike resolution and the minimal tissue response over the extended period of implantation in wild-type mice. Technology developed here can be applied to basic chronic electrophysiological studies as well as clinical implementation for neuro-rehabilitative applications.

ACS Style

Yuanyuan Guo; Shan Jiang; Benjamin J. B. Grena; Ian F. Kimbrough; Emily Thompson; Yoel Fink; Harald Sontheimer; Tatsuo Yoshinobu; Xiaoting Jia. Polymer Composite with Carbon Nanofibers Aligned during Thermal Drawing as a Microelectrode for Chronic Neural Interfaces. ACS Nano 2017, 11, 6574 -6585.

AMA Style

Yuanyuan Guo, Shan Jiang, Benjamin J. B. Grena, Ian F. Kimbrough, Emily Thompson, Yoel Fink, Harald Sontheimer, Tatsuo Yoshinobu, Xiaoting Jia. Polymer Composite with Carbon Nanofibers Aligned during Thermal Drawing as a Microelectrode for Chronic Neural Interfaces. ACS Nano. 2017; 11 (7):6574-6585.

Chicago/Turabian Style

Yuanyuan Guo; Shan Jiang; Benjamin J. B. Grena; Ian F. Kimbrough; Emily Thompson; Yoel Fink; Harald Sontheimer; Tatsuo Yoshinobu; Xiaoting Jia. 2017. "Polymer Composite with Carbon Nanofibers Aligned during Thermal Drawing as a Microelectrode for Chronic Neural Interfaces." ACS Nano 11, no. 7: 6574-6585.

Journal article
Published: 11 May 2017 in Optical Materials Express
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In this paper we propose a new and cost-effective fabrication scheme for porous polymer optical fibers. Different porous polymer fibers made from polycarbonate (PC) and poly(methyl methacrylate) (PMMA) using this method have been thermally drawn and characterized. Porosity in the fiber cladding is introduced by the absorbed water in one layer of the polymer fiber preforms under heat treatment and/or thermal drawing, and can be controlled by adjusting the water concentration. In addition, we have shown that the fabricated porous polymer fibers have the potential application in localized drug delivery for cancer treatment.

ACS Style

Li Yu; Haifeng Xuan; Yuanyuan Guo; Ai Lin Chin; Rong Tong; Gary Pickrell; Anbo Wang; Xiaoting Jia. Porous polymer optical fiber fabrication and potential biomedical application. Optical Materials Express 2017, 7, 1813 .

AMA Style

Li Yu, Haifeng Xuan, Yuanyuan Guo, Ai Lin Chin, Rong Tong, Gary Pickrell, Anbo Wang, Xiaoting Jia. Porous polymer optical fiber fabrication and potential biomedical application. Optical Materials Express. 2017; 7 (6):1813.

Chicago/Turabian Style

Li Yu; Haifeng Xuan; Yuanyuan Guo; Ai Lin Chin; Rong Tong; Gary Pickrell; Anbo Wang; Xiaoting Jia. 2017. "Porous polymer optical fiber fabrication and potential biomedical application." Optical Materials Express 7, no. 6: 1813.

Journal article
Published: 20 February 2017 in Nature Neuroscience
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The authors use fiber-based fabrication to create flexible biocompatible probes with integrated optical, electrical and microfluidic capabilities. Functionality is demonstrated by characterizing the temporal dynamics of opsin expression following viral delivery, long-term tracking of individual neuron action potentials and modulation of neural circuits in the context of mouse behavior. Optogenetic interrogation of neural pathways relies on delivery of light-sensitive opsins into tissue and subsequent optical illumination and electrical recording from the regions of interest. Despite the recent development of multifunctional neural probes, integration of these modalities in a single biocompatible platform remains a challenge. We developed a device composed of an optical waveguide, six electrodes and two microfluidic channels produced via fiber drawing. Our probes facilitated injections of viral vectors carrying opsin genes while providing collocated neural recording and optical stimulation. The miniature (<200 μm) footprint and modest weight (<0.5 g) of these probes allowed for multiple implantations into the mouse brain, which enabled opto-electrophysiological investigation of projections from the basolateral amygdala to the medial prefrontal cortex and ventral hippocampus during behavioral experiments. Fabricated solely from polymers and polymer composites, these flexible probes minimized tissue response to achieve chronic multimodal interrogation of brain circuits with high fidelity.

ACS Style

Seongjun Park; Yuanyuan Guo; Yuanyuan Guo Xiaoting Jia; Han Kyoung Choe; Benjamin Jean-Baptiste Grena; Jeewoo Kang; Jiyeon Park; Chi Lu; Andres Canales; Ritchie Chen; Yeong Shin Yim; Han Kyoung Choe Yeong Shin Yim Gloria B Choi; Yoel Fink; Seongjun Park Benjamin Grena Chi Lu Andres Canales Ritchie Chen Yoel Fink Polina Anikeeva. One-step optogenetics with multifunctional flexible polymer fibers. Nature Neuroscience 2017, 20, 612 -619.

AMA Style

Seongjun Park, Yuanyuan Guo, Yuanyuan Guo Xiaoting Jia, Han Kyoung Choe, Benjamin Jean-Baptiste Grena, Jeewoo Kang, Jiyeon Park, Chi Lu, Andres Canales, Ritchie Chen, Yeong Shin Yim, Han Kyoung Choe Yeong Shin Yim Gloria B Choi, Yoel Fink, Seongjun Park Benjamin Grena Chi Lu Andres Canales Ritchie Chen Yoel Fink Polina Anikeeva. One-step optogenetics with multifunctional flexible polymer fibers. Nature Neuroscience. 2017; 20 (4):612-619.

Chicago/Turabian Style

Seongjun Park; Yuanyuan Guo; Yuanyuan Guo Xiaoting Jia; Han Kyoung Choe; Benjamin Jean-Baptiste Grena; Jeewoo Kang; Jiyeon Park; Chi Lu; Andres Canales; Ritchie Chen; Yeong Shin Yim; Han Kyoung Choe Yeong Shin Yim Gloria B Choi; Yoel Fink; Seongjun Park Benjamin Grena Chi Lu Andres Canales Ritchie Chen Yoel Fink Polina Anikeeva. 2017. "One-step optogenetics with multifunctional flexible polymer fibers." Nature Neuroscience 20, no. 4: 612-619.

Journal article
Published: 31 December 2014 in Procedia Engineering
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A novel photoexcitation method for the light-addressable potentiometric sensor (LAPS) realized a higher spatial resolution of chemical imaging. In this method, a modulated light probe, which generates the alternating photocurrent signal, is surrounded by a ring of constant light, which suppresses the lateral diffusion of photocarriers by enhancing recombination. A device simulation verified that a higher spatial resolution could be obtained by adjusting the gap between the modulated and constant light. It was also found that a higher intensity and a longer wavelength of constant light was more effective. However, there exists a tradeoff between the spatial resolution and the amplitude of the photocurrent, and thus, the signal-to-noise ratio. A tilted incidence of constant light was applied, which could achieve even higher resolution with a smaller loss of photocurrent.

ACS Style

Yuanyuan Guo; Kosuke Seki; Ko-Ichiro Miyamoto; Torsten Wagner; Michael J. Schöning; Tatsuo Yoshinobu. Device Simulation of the Light-addressable Potentiometric Sensor with a Novel Photoexcitation Method for a Higher Spatial Resolution. Procedia Engineering 2014, 87, 456 -459.

AMA Style

Yuanyuan Guo, Kosuke Seki, Ko-Ichiro Miyamoto, Torsten Wagner, Michael J. Schöning, Tatsuo Yoshinobu. Device Simulation of the Light-addressable Potentiometric Sensor with a Novel Photoexcitation Method for a Higher Spatial Resolution. Procedia Engineering. 2014; 87 ():456-459.

Chicago/Turabian Style

Yuanyuan Guo; Kosuke Seki; Ko-Ichiro Miyamoto; Torsten Wagner; Michael J. Schöning; Tatsuo Yoshinobu. 2014. "Device Simulation of the Light-addressable Potentiometric Sensor with a Novel Photoexcitation Method for a Higher Spatial Resolution." Procedia Engineering 87, no. : 456-459.

Journal article
Published: 15 August 2014 in Sensors and Actuators B: Chemical
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As a semiconductor-based electrochemical sensor, the light-addressable potentiometric sensor (LAPS) can realize two dimensional visualization of (bio-)chemical reactions at the sensor surface addressed by localized illumination. Thanks to this imaging capability, various applications in biochemical and biomedical fields are expected, for which the spatial resolution is critically significant. In this study, therefore, the spatial resolution of the LAPS was investigated in detail based on the device simulation. By calculating the spatiotemporal change of the distributions of electrons and holes inside the semiconductor layer in response to a modulated illumination, the photocurrent response as well as the spatial resolution was obtained as a function of various parameters such as the thickness of the Si substrate, the doping concentration, the wavelength and the intensity of illumination. The simulation results verified that both thinning the semiconductor substrate and increasing the doping concentration could improve the spatial resolution, which were in good agreement with known experimental results and theoretical analysis. More importantly, new findings of interests were also obtained. As for the dependence on the wavelength of illumination, it was found that the known dependence was not always the case. When the Si substrate was thick, a longer wavelength resulted in a higher spatial resolution which was known by experiments. When the Si substrate was thin, however, a longer wavelength of light resulted in a lower spatial resolution. This finding was explained as an effect of raised concentration of carriers, which reduced the thickness of the space charge region. The device simulation was found to be helpful to understand the relationship between the spatial resolution and device parameters, to understand the physics behind it, and to optimize the device structure and measurement conditions for realizing higher performance of chemical imaging systems.

ACS Style

Yuanyuan Guo; Ko-Ichiro Miyamoto; Torsten Wagner; Micheal J. Schöning; Tatsuo Yoshinobu. Device simulation of the light-addressable potentiometric sensor for the investigation of the spatial resolution. Sensors and Actuators B: Chemical 2014, 204, 659 -665.

AMA Style

Yuanyuan Guo, Ko-Ichiro Miyamoto, Torsten Wagner, Micheal J. Schöning, Tatsuo Yoshinobu. Device simulation of the light-addressable potentiometric sensor for the investigation of the spatial resolution. Sensors and Actuators B: Chemical. 2014; 204 ():659-665.

Chicago/Turabian Style

Yuanyuan Guo; Ko-Ichiro Miyamoto; Torsten Wagner; Micheal J. Schöning; Tatsuo Yoshinobu. 2014. "Device simulation of the light-addressable potentiometric sensor for the investigation of the spatial resolution." Sensors and Actuators B: Chemical 204, no. : 659-665.

Journal article
Published: 23 May 2014 in Applied Physics Express
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ACS Style

Yuanyuan Guo; Kosuke Seki; Ko-Ichiro Miyamoto; Torsten Wagner; Michael J. Schoening; Tatsuo Yoshinobu. Novel photoexcitation method for light-addressable potentiometric sensor with higher spatial resolution. Applied Physics Express 2014, 7, 1 .

AMA Style

Yuanyuan Guo, Kosuke Seki, Ko-Ichiro Miyamoto, Torsten Wagner, Michael J. Schoening, Tatsuo Yoshinobu. Novel photoexcitation method for light-addressable potentiometric sensor with higher spatial resolution. Applied Physics Express. 2014; 7 (6):1.

Chicago/Turabian Style

Yuanyuan Guo; Kosuke Seki; Ko-Ichiro Miyamoto; Torsten Wagner; Michael J. Schoening; Tatsuo Yoshinobu. 2014. "Novel photoexcitation method for light-addressable potentiometric sensor with higher spatial resolution." Applied Physics Express 7, no. 6: 1.

Original paper
Published: 14 April 2014 in physica status solidi (a)
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The light‐addressable potentiometric sensor (LAPS) is a semiconductor‐based potentiometric sensor using a light probe with an ability of detecting the concentration of biochemical species in a spatially resolved manner. As an important biomedical sensor, research has been conducted to improve its performance, for instance, to realize high‐speed measurement. In this work, the idea of facilitating the device‐level simulation, instead of using an equivalent‐circuit model, is presented for detailed analysis and optimization of the performance of the LAPS. Both carrier distribution and photocurrent response have been simulated to provide new insight into both amplitude‐mode and phase‐mode operations of the LAPS. Various device parameters can be examined to effectively design and optimize the LAPS structures and setups for enhanced performance. Distribution of minority carriers inside a Si‐based LAPS structure under illumination with different wavelengths.

ACS Style

Yuanyuan Guo; Ko-Ichiro Miyamoto; Torsten Wagner; Michael J. Schoening; Tatsuo Yoshinobu. Theoretical study and simulation of light-addressable potentiometric sensors. physica status solidi (a) 2014, 211, 1467 -1472.

AMA Style

Yuanyuan Guo, Ko-Ichiro Miyamoto, Torsten Wagner, Michael J. Schoening, Tatsuo Yoshinobu. Theoretical study and simulation of light-addressable potentiometric sensors. physica status solidi (a). 2014; 211 (6):1467-1472.

Chicago/Turabian Style

Yuanyuan Guo; Ko-Ichiro Miyamoto; Torsten Wagner; Michael J. Schoening; Tatsuo Yoshinobu. 2014. "Theoretical study and simulation of light-addressable potentiometric sensors." physica status solidi (a) 211, no. 6: 1467-1472.