A simulation tool called HYDRA to optimize individual hydrogen infrastructure layouts is presented. The different electrolyzer technologies, namely proton exchange membrane electrolysis, anion exchange membrane electrolysis, alkaline electrolysis, and solid oxide electrolysis, as well as hydrogen storage possibilities are described in more detail and evaluated. To illustrate the application opportunities of HYDRA, three project examples are discussed. The examples include central and decentral applications while taking the usage of hydrogen into account.