Valter Longo

Dr. Valter Longo

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Academic Career Length

28Years (1999-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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16 April 2010 in Science
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LFLuigi Fontana
Luigi Fontana
LPLinda Partridge
Linda Partridge
VLValter Longo
Valter Longo
Eat Less, Live Long: Studies in several model organisms have shown that dietary restriction without malnutrition, or manipulation of nutrient-sensing pathways through mutations or drugs, can increase life span and reduce age-related disease. Fontana et al. (p. 321 ) review the ways in which nutrient-sensing pathways are central to aging. Studies of yeast, worms, rodents, and primates show that these pathways are conserved during evolution. Although data on the effects of dietary restriction in primates are very limited, in humans, the protective effects of dietary restriction against cancer, cardiovascular disease, and diabetes must be judged against potentially negative long-term effects. More work is needed to determine whether dietary restriction and the modulation of anti-aging pathways through drugs can extend life span and reduce pathologies in humans.
1 February 2014 in Cell Metabolism
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VLValter Longo
Valter Longo
MMMark Mattson
Mark Mattson
1 June 2016 in Cell Metabolism
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Journal Article
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VLValter Longo
Valter Longo
SPSatchidananda Panda
Satchidananda Panda
1 March 2014 in Cell Metabolism
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Journal Article
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MLMorgan E. Levine
Morgan E. Levine
JSJorge A. Suarez
Jorge A. Suarez
SBSebastian Brandhorst
Sebastian Brandhorst
PBPriya Balasubramanian
Priya Balasubramanian
CCChia-Wei Cheng
Chia-Wei Cheng
VLValter Longo
Valter Longo
1 July 2015 in Cell Metabolism
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Journal Article
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SBSebastian Brandhorst
Sebastian Brandhorst
ICIn Young Choi
In Young Choi
MWMin Wei
Min Wei
CCChia Wei Cheng
Chia Wei Cheng
SSSargis Sedrakyan
Sargis Sedrakyan
VLValter Longo
Valter Longo
7 March 2012 in Science Translational Medicine
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Journal Article
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CLChanghan Lee
Changhan Lee
LRLizzia Raffaghello
Lizzia Raffaghello
SBSebastian Brandhorst
Sebastian Brandhorst
FSFernando M. Safdie
Fernando M. Safdie
GBGiovanna Bianchi
Giovanna Bianchi
VLValter Longo
Valter Longo
Short-term starvation (or fasting) protects normal cells, mice, and potentially humans from the harmful side effects of a variety of chemotherapy drugs. Here, we show that treatment with starvation conditions sensitized yeast cells (Saccharomyces cerevisiae) expressing the oncogene-like RAS2val19 to oxidative stress and 15 of 17 mammalian cancer cell lines to chemotherapeutic agents. Cycles of starvation were as effective as chemotherapeutic agents in delaying progression of different tumors and increased the effectiveness of these drugs against melanoma, glioma, and breast cancer cells. In mouse models of neuroblastoma, fasting cycles plus chemotherapy drugs—but not either treatment alone—resulted in long-term cancer-free survival. In 4T1 breast cancer cells, short-term starvation resulted in increased phosphorylation of the stress-sensitizing Akt and S6 kinases, increased oxidative stress, caspase-3 cleavage, DNA damage, and apoptosis. These studies suggest that multiple cycles of fasting promote differential stress sensitization in a wide range of tumors and could potentially replace or augment the efficacy of certain chemotherapy drugs in the treatment of various cancers.