Lan Yan

Dr. Lan Yan

Naval Medical University, Shanghai, China
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Academic Career Length

12Years (2015-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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24 April 2019 in Frontiers in Microbiology
Verified
Journal Article
Open access
PDF file
JZJingxiang Zhang
Jingxiang Zhang
LLLiping Li
Liping Li
QLQuanzhen Lv
Quanzhen Lv
LYLan Yan
Lan Yan
YWYan Wang
Yan Wang
YJYuanying Jiang
Yuanying Jiang
CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is also the target of azole drugs in clinical practice. In recent years, researches on fungal CYP51 have stepped into a new stage attributing to the discovery of crystal structures of the homologs in Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. This review summarizes the functions, structures of fungal CYP51 proteins, and the inhibitors targeting these homologs. In particular, several drug-resistant mechanisms associated with the fungal CYP51s are introduced. The sequences and crystal structures of CYP51 proteins in different fungal species are also compared. These will provide new insights for the advancement of research on antifungal agents.
24 May 2016 in Virulence
Verified
Journal Article
Closed access
QLQuan-Zhen Lv
Quan-Zhen Lv
LYLan Yan
Lan Yan
YJYuanying Jiang
Yuanying Jiang
Sterols are the basal components of the membranes of the fungal pathogen Candida albicans, and these membranes determine the susceptibility of C. albicans cells to a variety of stresses, such as ionic, osmotic and oxidative pressures, and treatment with antifungal drugs. The common antifungal azoles in clinical use are targeted to the biosynthesis of ergosterol. In the past years, the synthesis, storage and metabolism of ergosterol in Saccharomyces cerevisiae has been characterized in some detail; however, these processes has not been as well investigated in the human opportunistic pathogen C. albicans. In this review, we summarize the genes involved in ergosterol synthesis and regulation in C. albicans. As well, genes in S. cerevisiae implicated in ergosterol storage and conversions with other lipids are noted, as these provide us clues and directions for the study of the homologous genes in C. albicans. In this report we have particularly focused on the essential roles of ergosterol in the dynamic process of cell biology and its fundamental status in the biological membrane system that includes lipid rafts, lipid droplets, vacuoles and mitochondria. We believe that a thorough understanding of this classic and essential pathway will give us new ideas about drug resistance and morphological switching in C. albicans.
16 June 2022 in Frontiers in Immunology
Verified
Journal Article
Open access
YHYufei He
Yufei He
JLJia Liu
Jia Liu
YCYutong Chen
Yutong Chen
LYLan Yan
Lan Yan
JWJianhua Wu
Jianhua Wu
Candida albicans is the most common pathogen causing clinical Candida infections. Neutrophils are a key member of the host innate immunity that plays an essential role in clearing invading C. albicans. In addition to the well-known defensive approaches such as phagocytosis, degranulation, and reactive oxygen species production, the formation of neutrophil extracellular traps (NETs) has also become an important way for neutrophils to defend against various pathogens. C. albicans has been reported to be capable of activating neutrophils to release NETs that subsequently kill fungi. The induction of NETs is affected by both the morphology and virulence factors of C. albicans, which also develops specific strategies to respond to the attack by NETs. Our review specifically focuses on the mechanisms by which C. albicans triggers NET formation and their subsequent interactions, which might provide meaningful insight into the innate immunity against C. albicans infection.
6 January 2015 in Virulence
Verified
Journal Article
Open access
XWXiaojuan Wang
Xiaojuan Wang
XSXue Sui
Xue Sui
LYLan Yan
Lan Yan
YWYan Wang
Yan Wang
YCYong-Bing Cao
Yong-Bing Cao
YJYuanying Jiang
Yuanying Jiang
Candida albicans is the most common cause of hematogenously disseminated candidiasis, and this disease is particularly prevalent in immunocompromised patients. The mortality of invasive candidiasis remains 40% to 50% even with the proper treatment with current antifungal drugs. Recently, with the better understanding of host-fungus interactions, notable progress has been made in antifungal vaccine research. Most antifungal vaccines exert protection by inducing either (or both) B-cell and T-cell responses. Here we summarize the current available information on C. albicans vaccines, highlight the obstacles that researchers identified, and offer several suggestions.
1 October 2017 in Vaccine
Verified
Journal Article
Closed access
XSXue Sui
Xue Sui
LYLan Yan
Lan Yan
YJYuan-Ying Jiang
Yuan-Ying Jiang
19 March 2015 in Medical Mycology
Verified
Journal Article
Open access
PDF file
XLXingxing Li
Xingxing Li
FYFeng Yang
Feng Yang
DLDedong Li
Dedong Li
MZMi Zhou
Mi Zhou
XWXiaojuan Wang
Xiaojuan Wang
YJYuanying Jiang
Yuanying Jiang
Genome plasticity is a hallmark of Candida albicans , and it has been suggested that it generates numerical and structural genomic variations as a means of adaptation. In this study, we used array based comparative genomic hybridization technology and the quantitative real time PCR to investigate the mechanisms by which the following strains obtained by genetic manipulation, CaLY188, CaLY350, CaLY190 and CaLY191, were resistant to antifungal azoles. All four showed trisomy of chromosome R and resistance to azoles. Serial passage of CaLY188 in drug-free medium resulted in chromosome loss, causing chromosome R disomy and loss of azole resistance. Thus we proposed that trisomy of chromosome R contributes to azole resistance.