Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) that usually begins in young adulthood and progressively leads to disability in most patients. Due to its increasing prevalence, its chronic course, and the partial effect of current disease-modifying drugs, MS has major socio-economical consequences. The overarching objective of our team is to decipher the pathophysiology of inflammatory diseases that target the CNS, with a particular focus on MS as well as other CNS autoimmune or infectious diseases.