Plant-based diets are becoming more popular for many reasons, and epidemiological as well as clinical data also suggest that a well-balanced vegan diet can be adopted for the prevention, and in some cases, in the treatment of many diseases. In this narrative review, we provide an overview of the relationships between these diets and various conditions and their potential biochemical background. As whole plant foods are very rich in food-derived antioxidants and other phytochemicals, they have many positive physiological effects on different aspects of health. In the background of the beneficial health effects, several biochemical processes could stand, including the reduced formation of trimethylamine oxide (TMAO) or decreased serum insulin-like growth factor 1 (IGF-1) levels and altered signaling pathways such as mechanistic target of rapamycin (mTOR). In addition, the composition of plant-based diets may play a role in preventing lipotoxicity, avoiding N-glycolylneuraminic acid (Neu5Gc), and reducing foodborne endotoxin intake. In this article, we attempt to draw attention to the growing knowledge about these diets and provide starting points for further research.

Health and sustainability problems have become a central theme in dialogue in both the scientific community and the public. Our individual choices have a profound, advantageous or disadvantageous impact on our health; the same can be said about our environmental footprint. In this area, we can also make decisions that affect the physical environment positively or negatively. Our narrative review aims to demonstrate that healthy plant-based choices in our diet are linked to choices beneficial for our environment and that these two seemingly distant aspects converge in the context of plant-based diets. We have collected, compared and discussed the results of life cycle analysis (LCA) articles on the current state of the effect of food choice on our environment. Furthermore, we would like to show the opportunities and constraints of implementing plant-based diets.