Breast cancer is one of the most frequently diagnosed solid cancers. Mammography is the most commonly used screening technology for detecting breast cancer. Traditional machine learning methods of mammographic image classification or segmentation using manual features require a great quantity of manual segmentation annotation data to train the model and test the results. But manual labeling is expensive, time-consuming, and laborious, and greatly increases the cost of system construction. To reduce this cost and the workload of radiologists, an end-to-end full-image mammogram classification method based on deep neural networks was proposed for classifier building, which can be constructed without bounding boxes or mask ground truth label of training data. The only label required in this method is the classification of mammographic images, which can be relatively easy to collect from diagnostic reports. Because breast lesions usually take up a fraction of the total area visualized in the mammographic image, we propose different pooling structures for convolutional neural networks(CNNs) instead of the common pooling methods, which divide the image into regions and select the few with high probability of malignancy as the representation of the whole mammographic image. The proposed pooling structures can be applied on most CNN-based models, which may greatly improve the models' performance on mammographic image data with the same input. Experimental results on the publicly available INbreast dataset and CBIS dataset indicate that the proposed pooling structures perform satisfactorily on mammographic image data compared with previous state-of-the-art mammographic image classifiers and detection algorithm using segmentation annotations.

Automatic vessel segmentation in the fundus images plays an important role in the screening, diagnosis, treatment, and evaluation of various cardiovascular and ophthalmologic diseases. However, due to the limited well-annotated data, varying size of vessels, and intricate vessel structures, retinal vessel segmentation has become a long-standing challenge. In this paper, a novel deep learning model called AACA-MLA-D-UNet is proposed to fully utilize the low-level detailed information and the complementary information encoded in different layers to accurately distinguish the vessels from the background with low model complexity. The architecture of the proposed model is based on U-Net, and the dropout dense block is proposed to preserve maximum vessel information between convolution layers and mitigate the over-fitting problem. The adaptive atrous channel attention module is embedded in the contracting path to sort the importance of each feature channel automatically. After that, the multi-level attention module is proposed to integrate the multi-level features extracted from the expanding path, and use them to refine the features at each individual layer via attention mechanism. The proposed method has been validated on the three publicly available databases, i.e. the DRIVE, STARE, and CHASE $\_$ DB1. The experimental results demonstrate that the proposed method can achieve better or comparable performance on retinal vessel segmentation with lower model complexity. Furthermore, the proposed method can also deal with some challenging cases and has strong generalization ability.

Motion models have been proved to be a crucial part in the visual tracking process. In recent trackers, particle filter and sliding windows-based motion models have been widely used. Treating motion models as a sequence prediction problem, we can estimate the motion of objects using their trajectories. Moreover, it is possible to transfer the learned knowledge from annotated trajectories to new objects. Inspired by recent advance in deep learning for visual feature extraction and sequence prediction, we propose a trajectory predictor to learn prior knowledge from annotated trajectories and transfer it to predict the motion of target objects. In this predictor, convolutional neural networks extract the visual features of target objects. Long short-term memory model leverages the annotated trajectory priors as well as sequential visual information, which includes the tracked features and center locations of the target object, to predict the motion. Furthermore, to extend this method to videos in which it is difficult to obtain annotated trajectories, a dynamic weighted motion model that combines the proposed trajectory predictor with a random sampler is proposed. To evaluate the transfer performance of the proposed trajectory predictor, we annotated a real-world vehicle dataset. Experiment results on both this real-world vehicle dataset and an online tracker benchmark dataset indicate that the proposed method outperforms several state-of-the-art trackers.

Classifying breast cancer histopathological images automatically is an important task in computer assisted pathology analysis. However, extracting informative and non-redundant features for histopathological image classification is challenging due to the appearance variability caused by the heterogeneity of the disease, the tissue preparation, and staining processes. In this paper, we propose a new feature extractor, called deep manifold preserving autoencoder, to learn discriminative features from unlabeled data. Then, we integrate the proposed feature extractorwith a softmax classifier to classify breast cancer histopathology images. Specifically, it learns hierarchal features from unlabeled image patches by minimizing the distance between its input and output, and simultaneously preserving the geometric structure of the whole input data set. After the unsupervised training, we connect the encoder layers of the trained deep manifold preserving autoencoder with a softmax classifier to construct a cascade model and fine-tune this deep neural network with labeled training data. The proposed method learns discriminative features by preserving the structure of the input datasets from the manifold learning view and minimizing reconstruction errorfrom the deep learning view from a large amount of unlabeled data. Extensive experiments on the public breast cancer dataset (BreaKHis) demonstrate the effectiveness of the proposed method.