Skin cancer is a prevalent form of malignancy globally, and its early and accurate diagnosis is critical for patient survival. Clinical evaluation of skin lesions is essential, but it faces challenges such as long waiting times and subjective interpretations. Deep learning techniques have been developed to tackle these challenges and assist dermatologists in making more accurate diagnoses. Prompt treatment of skin cancer is vital to prevent its progression and potentially life-threatening consequences. The use of deep learning algorithms can improve the speed and accuracy of diagnosis, leading to earlier detection and treatment. Additionally, it can reduce the workload for healthcare professionals, allowing them to concentrate on more complex cases. The goal of this study was to develop reliable deep learning (DL) prediction models for skin cancer classification; (i) deal with a typical severe class imbalance problem, which arises because the skin-affected patients’ class is significantly smaller than the healthy class; and (ii) interpret the model output to better understand the decision-making mechanism (iii) Propose an End-to-End smart healthcare system through an android application. In a comparison examination with six well-known classifiers, the effectiveness of the proposed DL technique was explored in terms of metrics relating to both generalization capability and classification accuracy. A study used the HAM10000 dataset and an optimized CNN to identify the seven forms of skin cancer. The model was trained using two optimization functions (Adam and RMSprop) and three activation functions (Relu, Swish, and Tanh). Furthermore, an XAI-based skin lesion classification system was developed, incorporating Grad-CAM and Grad-CAM++ to explain the model’s decisions. This system can help doctors make informed skin cancer diagnoses in their early stages, with an 82% classification accuracy and 0.47% loss accuracy.

Stroke is a dangerous medical disorder that occurs when blood flow to the brain is disrupted, resulting in neurological impairment. It is a big worldwide threat with serious health and economic implications. To solve this, researchers are developing automated stroke prediction algorithms, which would allow for early intervention and perhaps save lives. The number of people at risk for stroke is growing as the population ages, making precise and effective prediction systems increasingly critical. The goal of this study was study aimed to achieve three objectives: (i) to create a trustworthy machine learning model to predict stroke disease, (ii) to address the severe class imbalance issue that results from the stroke patients’ class being substantially smaller than the healthy class, and (iii) by using Mutual Information Score, Chi-Square Score, and ANOVA test, find the import feature(iv) to interpret the model output to gain a better comprehension of the decision-making process (v) balancing the dataset from the ratio of 19: 1 for No Stroke: Stroke to equal ratio using SMOTE Analysis (vi) Propose an End-to-End smart healthcare system through an android application. In a comparison examination with six well-known classifiers, the effectiveness of the proposed ML technique was explored in terms of metrics relating to both generalization capability and prediction accuracy. To give insight into the black-box machine learning models, we also studied two kinds of explainable techniques, namely SHAP and LIME, in this study. SHAP (Shapley Additive Explanations) and LIME (Local Interpretable Model-agnostic Explanations) are well-established and reliable approaches for explaining model decision-making, particularly in the medical industry. The findings of the experiment revealed that more complicated models outperformed simpler ones, with the top model obtaining almost 91% accuracy and the other models achieving 83-91% accuracy. The proposed framework, which includes global and local explainable methodologies, can aid in standardizing complicated models and gaining insight into their decision-making, which can enhance stroke care and treatment.