Osteoarthritis (OA) is a degenerative joint disease caused by chronic inflammation that damages articular cartilage. At present, the treatment of OA includes drug therapy to relieve symptoms and joint replacement therapy for advanced OA. However, these palliatives cannot truly block the progression of the disease from the immunological pathogenesis of OA. In recent years, bone marrow mesenchymal stem cell (BMSC) transplantation has shown great potential in tissue engineering repair. In addition, many studies have shown that BMSC paracrine signals play an important role in the treatment of OA through immune regulation and suppressing inflammation. At present, the mechanism of inflammation-induced OA and the use of BMSC transplantation in joint repair have been reviewed, but the mechanism and significance of BMSC paracrine signals in the treatment of OA have not been fully reviewed. Therefore, this article focused on the latest research progress on the paracrine effects of BMSCs in the treatment of OA and the related mechanisms by which BMSCs secrete cytokines to inhibit the inflammatory response, regulate immune balance, and promote cell proliferation and differentiation. In addition, the application potential of BMSC-Exos as a new type of cell-free therapy for OA is described. This review aimed to provide systematic theoretical support for the clinical application of BMSC transplantation in the treatment of OA.

Accurate prediction of the water-bearing capacity of aquifers is crucial for protecting the surface ecological environment and ensuring safety during coal mining. In this study, a macro–micro combination was used to investigate the water-bearing capacity of bedrock aquifers. At the micro-level, the micro pore parameters of various sandstones were determined through cast sheeting. At the macro-level, the porosity and water absorption rate of various sandstones were determined experimentally. After that, a new index weighting method was proposed to comprehensively evaluate the water-bearing capacity index of sandstone. According to this method, the water-bearing capacity of aquifers in the Guojiahe coalmine were evaluated. The research results revealed that the water-bearing capacity of sandstone was mainly related to its pore connectivity, and the water-bearing capacity of sandstone in the Luo’he and Zhi’luo formation was considerably greater than that in the Yan’an formation. The water bearing capacity of strata in the eastern part of the mining area is lower than that in the western part of the mining area. The research results can provide considerable money savings for coal mining and protect the ecological environment and groundwater resources in the region.

This study targets key challenges in ameliorating the plow-layer soil of coastal saline soils. A field experiment under a wheat–maize rotation was established with six treatments: CK, control with no organic inputs; A1, 45 t ha⁻¹ organic manure; A2, 45 t ha⁻¹ organic manure + microbial inoculant; A3, 45 t ha⁻¹ organic manure + microbial inoculant + plastic-film mulching; A4, 90 t ha⁻¹ organic manure; and A5, 135 t ha⁻¹ organic manure. By applying high rates of organic manure alone or in combination with microbial inoculation and mulching, we aimed to strengthen soil water–salt regulation, improve plow-layer soil quality, and ultimately promote crop growth and yield formation. We further quantified treatment-induced shifts in soil physicochemical properties and linked them to crop growth and yield responses. The results indicated that, compared with CK, plow-layer soil organic carbon increased by 45.56% and 107.91% under A3 and A4, respectively, while soil salinity decreased by 70.57% and 67.42%. All manure-based treatments increased yield relative to CK, with the highest yields achieved under A3 and A4: wheat yield reached 7628.16 and 7888.01 kg ha⁻¹, and maize yield reached 8828.29 and 8716.01 kg ha⁻¹, respectively. Overall, high-rate organic manure—especially when integrated with microbial inoculation and plastic mulching—substantially enhanced soil fertility while alleviating salinity stress, resulting in an integrated “fertility build-up–salinity reduction–yield enhancement” amelioration effect. This technology package offers a feasible pathway for improving coastal saline farmland and stabilizing productivity under rotation systems, with strong potential for further on-farm demonstration and wider adoption.