Elisabeth Davioud-Charvet

Dr. Elisabeth Davioud-Charvet

orcid

Research Focus & Metrics

Academic Career Length

42Years (1985-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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19 June 2007 in PLOS Medicine
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Journal Article
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AKAngela N Kuntz
Angela N Kuntz
EDElisabeth Davioud-Charvet
Elisabeth Davioud-Charvet
ASAhmed A Sayed
Ahmed A Sayed
LCLindsay L Califf
Lindsay L Califf
JDJean Dessolin
Jean Dessolin
DWDavid L Williams
David L Williams
Schistosomiasis—infection with helminth parasites in the genus Schistosoma, including S. mansoni—is a widespread, devastating tropical disease affecting more than 200 million people. No vaccine is available, and praziquantel, the only drug extensively utilized, is currently administered more than 100 million people yearly. Because praziquantel resistance may develop it is essential to identify novel drug targets. Our goal was to investigate the potential of a unique, selenium-containing parasite enzyme thioredoxin glutathione reductase (TGR) as a drug target. Using RNA interference we found that TGR is essential for parasite survival; after silencing of TGR expression, in vitro parasites died within 4 d. We also found that auranofin is an efficient inhibitor of pure TGR (Ki = 10 nM), able to kill parasites rapidly in culture at physiological concentrations (5 μM), and able to partially cure infected mice (worm burden reductions of ~60%). Furthermore, two previously used antischistosomal compounds inhibited TGR activity, suggesting that TGR is a key target during therapy with those compounds. Collectively, our results indicate that parasite TGR meets all the major criteria to be a key target for antischistosomal chemotherapy. To our knowledge this is the first validation of a Schistosoma drug target using a convergence of both genetic and biochemical approaches.

13 January 2001 in Journal of Medicinal Chemistry
Verified
Journal Article
Closed access
LSLaurence Salmon-Chemin
Laurence Salmon-Chemin
EBEric Buisine
Eric Buisine
VYVanessa Yardley
Vanessa Yardley
SKSven Kohler
Sven Kohler
MDMarie-Ange Debreu
Marie-Ange Debreu
EDElisabeth Davioud-Charvet
Elisabeth Davioud-Charvet

6 March 2006 in Angewandte Chemie International Edition
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Journal Article
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SUSabine Urig
Sabine Urig
KFKarin Fritz‐Wolf
Karin Fritz‐Wolf
RRRégis Réau
Régis Réau
CHChristel Herold‐Mende
Christel Herold‐Mende
KTKatalin Tóth
Katalin Tóth
KBKatja Becker
Katja Becker

26 October 2004 in Journal of Medicinal Chemistry
Verified
Journal Article
Closed access
CBChristophe Biot
Christophe Biot
HBHolger Bauer
Holger Bauer
RSR. Heiner Schirmer
R. Heiner Schirmer
EDElisabeth Davioud-Charvet
Elisabeth Davioud-Charvet

1 July 2012 in Gastroenterology
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Journal Article
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SHSibylle Haid
Sibylle Haid
ANAlexandra Novodomská
Alexandra Novodomská
JGJuliane Gentzsch
Juliane Gentzsch
CGChristina Grethe
Christina Grethe
SGSilvia Geuenich
Silvia Geuenich
TPThomas Pietschmann
Thomas Pietschmann

17 June 2000 in Journal of Medicinal Chemistry
Verified
Journal Article
Closed access
SGSophie Girault
Sophie Girault
PGPhilippe Grellier
Philippe Grellier
ABAmaya Berecibar
Amaya Berecibar
LMLouis Maes
Louis Maes
EMElisabeth Mouray
Elisabeth Mouray
CSChristian Sergheraert
Christian Sergheraert