Dr. Lianzhong Zhao

Shenzhen University

Dr. Lianzhong Zhao

Shenzhen University

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Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

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23 July 2021 in Viruses

Journal Article

3-Indoleacetonitrile Is Highly Effective in Treating Influenza A Virus Infection In Vitro and In Vivo

Influenza A viruses are serious zoonotic pathogens that continuously cause pandemics in several animal hosts, including birds, pigs, and humans. Indole derivatives containing an indole core framework have been extensively studied and developed to prevent and/or treat viral infection. This study evaluated the anti-influenza activity of several indole derivatives, including 3-indoleacetonitrile, indole-3-carboxaldehyde, 3-carboxyindole, and gramine, in A549 and MDCK cells. Among these compounds, 3-indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, as tested in A549 cells. Importantly, in a mouse model, 3-indoleacetonitrile with a non-toxic concentration of 20 mg/kg effectively reduced the mortality and weight loss, diminished lung virus titers, and alleviated lung lesions of mice lethally challenged with A/duck/Hubei/WH18/2015 H5N6 and A/Puerto Rico/8/1934 H1N1 influenza A viruses. The antiviral properties enable the potential use of 3-indoleacetonitrile for the treatment of IAV infection.

About Me

PhD student, Huazhong Agriculture University, 09/2012-12/2015 Research interest has focused on influenza a virus-host interaction in the scope of cellular microRNAs, of which miR-136 was identified as an important immune regulator during virus infection. Postdoctoral fellow, Huazhong Agriculture University, 01/2016-04/2019 Research topic: miRNA regulation on IAV replication; Protein-protein interaction of host factors with IAV components; Antiviral drug screening. Postdoctoral fellow, University of Alabama at Birmingham, 05/2019-10/2020 Research topic: Molecular mechanism for leukemogenesis. Characterized the role of MEF2D and JADE2 on maintaining MLL-rearrangement AML cell survival, growth, and differentiation. Research Associate, Shenzhen University, 05/2021-now College of Life Sciences and Oceanography. Research interest: Infection and tumor immunology. FUNDINGS: 1. National Natural Science Foundation of China (Grant No. 31702251), PI. 2. China Postdoctoral Science Foundation (Grant No. 2016M602325), PI. 3. National Natural Science Foundation of China (Grant No. 31602195, Grant No. 31560698, Grant No. 31100057, Grant No. 31820103015), Participant. 4. Hollis Brownstein Research Grant, 07/01/2019-06/30/2020. Participant. 5. Conquer Cancer Now Grant, 10/01/2020-09/30/2022. Participant. 6. ASH Scholar Award (awarded), 07/01/2021-06/30/2023. Participant.

Dr. Lianzhong Zhao

Dr. Lianzhong Zhao

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About Me