Sheng Cai

Prof. Sheng Cai

College of Pharmacy, Zhejiang University, Hangzhou, China
orcid

Research Focus & Metrics

Academic Career Length

8Years (2019-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 April 2020 in Journal of Pharmaceutical Analysis
Verified
Journal Article
Open access
MSMinzhe Shen
Minzhe Shen
YZYing Zhou
Ying Zhou
JYJiawei Ye
Jiawei Ye
AAAbdu Ahmed Abdullah Al-Maskri
Abdu Ahmed Abdullah Al-Maskri
YKYu Kang
Yu Kang
Sheng CaiSheng Cai
Sheng Cai
The recent pneumonia outbreak caused by a novel coronavirus (SARS-CoV-2) is posing a great threat to global public health. Therefore, rapid and accurate identification of pathogenic viruses plays a vital role in selecting appropriate treatments, saving people’s lives and preventing epidemics. It is important to establish a quick standard diagnostic test for the detection of the infectious disease (COVID-19) to prevent subsequent secondary spread. Polymerase chain reaction (PCR) is regarded as a gold standard test for the molecular diagnosis of viral and bacterial infections with high sensitivity and specificity. Isothermal nucleic acid amplification is considered to be a highly promising candidate method due to its fundamental advantage in quick procedure time at constant temperature without thermocycler operation. A variety of improved or new approaches also have been developed. This review summarizes the currently available detection methods for coronavirus nucleic acid. It is anticipated that this will assist researchers and clinicians in developing better techniques for timely and effective detection of coronavirus infection.

1 August 2019 in Journal of Pharmaceutical Analysis
Verified
Journal Article
Open access
JYJiawei Ye
Jiawei Ye
MXMingcheng Xu
Mingcheng Xu
XTXueke Tian
Xueke Tian
Sheng CaiSheng Cai
Sheng Cai
Su ZengSu Zeng
Su Zeng
MicroRNAs (miRNAs) are a family of endogenous, small (approximately 22 nucleotides in length), noncoding, functional RNAs. With the development of molecular biology, the research of miRNA biological function has attracted significant interest, as abnormal miRNA expression is identified to contribute to serious human diseases such as cancers. Traditional methods for miRNA detection do not meet current demands. In particular, nanomaterial-based methods, nucleic acid amplification-based methods such as rolling circle amplification (RCA), loop-mediated isothermal amplification (LAMP), strand-displacement amplification (SDA) and some enzyme-free amplifications have been employed widely for the highly sensitive detection of miRNA. MiRNA functional research and clinical diagnostics have been accelerated by these new techniques. Herein, we summarize and discuss the recent progress in the development of miRNA detection methods and new applications. This review will provide guidelines for the development of follow-up miRNA detection methods with high sensitivity and specificity, and applicability to disease diagnosis and therapy.

1 November 2021 in Journal of Pharmaceutical and Biomedical Analysis
Verified
Journal Article
Closed access
JTJadera Talap
Jadera Talap
JZJing Zhao
Jing Zhao
MSMinzhe Shen
Minzhe Shen
ZSZihan Song
Zihan Song
HZHui Zhou
Hui Zhou
Sheng CaiSheng Cai
Sheng Cai

1 October 2019 in Analytica Chimica Acta
Verified
Journal Article
Closed access
MXMingcheng Xu
Mingcheng Xu
JYJiawei Ye
Jiawei Ye
DYDan Yang
Dan Yang
AAAbdu Ahmed Abdullah Al-Maskri
Abdu Ahmed Abdullah Al-Maskri
HHHaihong Hu
Haihong Hu
Su ZengSu Zeng
Su Zeng

1 August 2020 in Analytica Chimica Acta
Verified
Journal Article
Closed access
AAAbdu Ahmed Abdullah Al-Maskri
Abdu Ahmed Abdullah Al-Maskri
JYJiawei Ye
Jiawei Ye
JTJadera Talap
Jadera Talap
HHHaihong Hu
Haihong Hu
LSLianli Sun
Lianli Sun
Su ZengSu Zeng
Su Zeng