Laura Mora-Lopez

Dr. Laura Mora-Lopez

orcid

Research Focus & Metrics

Academic Career Length

24Years (2003-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
1 April 2009 in Annals of Surgery
Verified
Journal Article
Closed access
XSXavier Serra-Aracil
Xavier Serra-Aracil
JBJordi Bombardo-Junca
Jordi Bombardo-Junca
JMJuan Moreno-Matias
Juan Moreno-Matias
ADAnna Darnell
Anna Darnell
LMLaura Mora-Lopez
Laura Mora-Lopez
SNSalvador Navarro-Soto
Salvador Navarro-Soto
The prevalence of terminal parastomal hernia (PH) after colostomy placement may be as high as 50%. The effect of the PH may range from discomfort to life-threatening complications. Surgical procedures for repairing PH are difficult to perform and present a high-failure rate. To reduce the incidence of PH by implanting a lightweight mesh in the sublay position. Randomized, controlled, prospective study. Patients were scheduled for permanent end colostomy surgery to treat cancer of the lower third of the rectum, performed by the same colorectal surgery team. An Ultrapro lightweight mesh was inserted in the sublay position in the study group. Using simple randomization, the sample size required was estimated to be 27 per group. Patients were followed-up clinically and radiologically with abdominal computed tomography by an independent clinician and a radiologist who were all blind to the aims of the study, 1 month and every 6 months after surgery. : The groups were homogeneous in terms of their clinical and demographic characteristics. Surgical time and postoperative morbidity were similar in the 2 groups. Mortality was 0. No mesh intolerance was reported. In the clinical follow-up (median: 29 months, range: 13-49), 11/27 (40.7%) hernias were recorded in the control group compared with 4/27 (14.8%) in the study group (P = 0.03). Abdominal computed tomography identified 14/27 (44.4%) hernias in the control group compared with 6/27 (22.2%) in the study group (P = 0.08). Parastomal placement of a mesh reduces the appearance of PH. The technique is safe, well-tolerated, and does not increase morbidity rates.

11 May 2011 in World Journal of Surgery
Verified
Journal Article
Closed access
PDF file
MAM. Alcántara
M. Alcántara
XSX. Serra‐Aracil
X. Serra‐Aracil
JFJ. Falcó
J. Falcó
LMLaura Mora-Lopez
Laura Mora-Lopez
JBJ. Bombardó
J. Bombardó
SNS. Navarro
S. Navarro

12 January 2009 in Colorectal Disease
Verified
Journal Article
Closed access
PDF file
JMJ. Moreno‐Matias
J. Moreno‐Matias
XSX. Serra‐Aracil
X. Serra‐Aracil
ADA. Darnell‐Martin
A. Darnell‐Martin
JBJ. Bombardo‐Junca
J. Bombardo‐Junca
LMLaura Mora-Lopez
Laura Mora-Lopez
SNS. Navarro‐Soto
S. Navarro‐Soto

30 April 2003 in British Journal of Surgery
Verified
Journal Article
Closed access
PDF file
SBS. Biondo
S. Biondo
DPDavid Parés
David Parés
LMLaura Mora-Lopez
Laura Mora-Lopez
JRJ. Martí Ragué
J. Martí Ragué
EKE. Kreisler
E. Kreisler
EJE. Jaurrieta
E. Jaurrieta

1 December 2016 in Annals of Surgery
Verified
Journal Article
Closed access
MLManuel López-Cano
Manuel López-Cano
XSXavier Serra-Aracils
Xavier Serra-Aracils
LMLaura Mora-Lopez
Laura Mora-Lopez
JSJosé Luis Sánchez-García
José Luis Sánchez-García
LJLuis Miguel Jiménez-Gómez
Luis Miguel Jiménez-Gómez
MAManuel Armengol-Carrasco
Manuel Armengol-Carrasco
The aim of this study was to assess the reduction in the incidence of parastomal hernia (PH) after placement of prophylactic synthetic mesh using a modified Sugarbaker technique when a permanent end-colostomy is needed. Prevention of PH formation is crucial given the high prevalence of PH and difficulties in the surgical repair of PH. A randomized, prospective, double-blind, and controlled trial. Rectal cancer patients undergoing laparoscopic abdominoperineal resection with permanent colostomy were randomized (1 : 1) to the mesh and nonmesh arms. In the mesh group, a large-pore lightweight composite mesh was placed in the intraperitoneal/onlay fashion using a modified Sugarbaker technique. PH was detected by computed tomography (CT) after a minimum follow-up of 12 months. Analysis was per-protocol. The mesh group included 24 patients and the control group 28. Preoperative data, surgical time, and postoperative morbidity were similar. The median follow-up was 26 months. After CT examination, 6 of 24 PHs (25%) were observed in the mesh group compared with 18 of 28 (64.3%) in the nonmesh group (odds ratio 0.39, 95% confidence interval 0.18–0.82; P = 0.005). The Kaplan-Meier curves showed significant differences in favor of the mesh group (long-rank = 4.21, P = 0.04). The number needed to treat was 2.5, which confirmed the effectiveness of the intervention. Placement of a prosthetic mesh by the laparoscopic approach following the modified Sugarbaker technique is safe and effective in the prevention of PH, reducing significantly the incidence of PH.

1 January 2014 in World Journal of Gastroenterology
Verified
Journal Article
Open access
XSXavier Serra-Aracil
Xavier Serra-Aracil
LMLaura Mora-Lopez
Laura Mora-Lopez
MAManel Alcantara-Moral
Manel Alcantara-Moral
ACAleidis Caro-Tarrago
Aleidis Caro-Tarrago
CGCarlos Javier Gomez-Diaz
Carlos Javier Gomez-Diaz
SNSalvador Navarro-Soto
Salvador Navarro-Soto
Total mesorectal excision (TME) is the standard treatment for rectal cancer, but complications are frequent and rates of morbidity, mortality and genitourinary alterations are high. Transanal endoscopic microsurgery (TEM) allows preservation of the anal sphincters and, via its vision system through a rectoscope, allows access to rectal tumors located as far as 20 cm from the anal verge. The capacity of local surgery to cure rectal cancer depends on the risk of lymph node invasion. This means that correct preoperative staging of the rectal tumor is necessary. Currently, local surgery is indicated for rectal adenomas and adenocarcinomas invading the submucosa, but not beyond (T1). Here we describe the standard technique for TEM, the different types of equipment used, and the technical limitations of this approach. TEM to remove rectal adenoma should be performed in the same way as if the lesion were an adenocarcinoma, due to the high percentage of infiltrating adenocarcinomas in these lesions. In spite of the generally good results with T1, some authors have published surprisingly high recurrence rates; this is due to the existence of two types of lesions, tumors with good and poor prognosis, divided according to histological and surgical factors. The standard treatment for rectal adenocarcinoma T2N0M0 is TME without adjuvant therapy. In this type of adenocarcinoma, local surgery obtains the best results when complete pathological response has been achieved with previous chemoradiotherapy. The results with chemoradiotherapy and TEM are encouraging, but the scientific evidence remains limited at present.