Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a human kinase interaction network covering more than 300 kinases. The interaction dataset is a high-quality resource with more than 5,000 previously unreported interactions. We extensively characterized the obtained network and were able to identify previously described, as well as predict new, kinase functional associations, including those of the less well-studied kinases PIM3 and protein O-mannose kinase (POMK). Importantly, the presented interaction map is a valuable resource for assisting biomedical studies. We uncover dozens of kinase-disease associations spanning from genetic disorders to complex diseases, including cancer.

The Environmental Data Portal EnviDat aims to fuse data publication repository functionalities with next-generation web-based environmental geospatial information systems (web-EGIS) and Earth Observation (EO) data cube functionalities. User requirements related to mapping and visualization represent a major challenge for current environmental data portals. The new Cloud Optimized Raster Encoding (CORE) format enables an efficient storage and management of gridded data by applying video encoding algorithms. Inspired by the cloud optimized GeoTIFF (COG) format, the design of CORE is based on the same principles that enable efficient workflows on the cloud, addressing web-EGIS visualization challenges for large environmental time series in geosciences. CORE is a web-native streamable format that can compactly contain raster imagery as a data hypercube. It enables simultaneous exchange, preservation, and fast visualization of time series raster data in environmental repositories. The CORE format specifications are open source and can be used by other platforms to manage and visualize large environmental time series.

Tandem mass spectrometry and sequence database searching are widely used in proteomics to identify peptides in complex mixtures. Here we present a benchmark study in which a pool of 20,103 synthetic peptides was measured and the resulting data set was analyzed using around 1800 different software and parameter set combinations. The results indicate a strong relationship between the performance of an analysis workflow and the applied parameter settings. We present and discuss strategies to optimize parameter settings in order to significantly increase the number of correctly assigned fragment ion spectra and to make the analysis method robust.

The strategic initiative EnviDat highlights the importance WSL lays on Research Data Management (RDM) at the institutional level and demonstrates the