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Prof. Hedi Mansour
university of Monastir

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Research Keywords & Expertise

0 plasticizer
0 Toxicological
0 Toxicological and biochemical analysis
0 Toxicological Analysis
0 Contamiants of emerging concern

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Short Biography

Hedi BEN MANSOUR Ph.D in Environmental Toxicology from Caen Normandy University France Full professor at Monastir University – Tunisia. Hedi Ben Mansour is a director of the Research Unit of Analysis and Process Applied to the Environment APAE- UR17ES32. He has received many awards, appreciations, and recognition for many international organizations such the award of the young Francophone researchers in Sciences and Medicine (Sao Paulo Brézil in 2013). Currently, he is a consultant at several international organizations including ARSCO, AUF… He is visiting professor of some European university and he holds life memberships of various international organizations and is an active participant in national and international scientific events. Currently Prof Ben Mansour is engaging in studying the investigation of causes and the consequences of water pollution by micro pollutants (plasticizers, pharmaceutical residues, textile dyes, endocrine disruptors, etc.). The originality of its work lies in the development and realization of chemical and biological techniques for a correct analysis of water as well as the design of processes for the treatment and recovery of treated water. Currently his research team is participating in four EU funded research projects. Hedi BEN MANSOUR has published more than 108 scientific articles with peer review and holds an h index of 18 has successfully supervised 10 PhDs, is an Editorial Board Member of 04 international journals.

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Journal article
Published: 13 May 2021 in International Journal of Environmental Research and Public Health
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Total mercury (Hg) was determined in 450 environmental samples (seawater, sediment plant and fish) from five Mahdia coastal areas (Tunisia). Tolerable Weekly Intake% (TWI) values, according to the European Food Safety Authority (EFSA), were calculated based on the average metal concentration in fish and the average weekly fish consumption rate. Hg was accumulated mainly in fish and in Posidonia oceanica leaves. Hg in sediment ranged from 1.88 μg/kg dry weight (d.w.) to 7.48 μg/kg d.w., while it was between 0.32 μg/kg and 0.19 μg/kg in seawaters. Our study showed high concentration in Posidonia oceanica in S3 (plant = 16.76 ± 4.48 μg/kg d.w.) as compared to those in S4 sites (plant = 5.33 ± 0.05 μg/kg d.w.). Concentrations for S. aurata and S. salpa in the Rejiche area exceeded the EC 1881/2006 legislation with values of 1.9 mg/kg and 2.5 mg/kg, respectively, and consumers may be exposed to high concentrations of Hg that exceeds the EFSA. The results showed that the fish species should be constantly monitored due to their TWI% of 154.5% for S. aurata and 209.8% S. salpa respectively.

ACS Style

Amel Jebara; Vincenzo Lo Turco; Caterina Faggio; Patrizia Licata; Vincenzo Nava; Angela Potortì; Rosalia Crupi; Hedi Mansour; Giuseppa Di Bella. Monitoring of Environmental Hg Occurrence in Tunisian Coastal Areas. International Journal of Environmental Research and Public Health 2021, 18, 5202 .

AMA Style

Amel Jebara, Vincenzo Lo Turco, Caterina Faggio, Patrizia Licata, Vincenzo Nava, Angela Potortì, Rosalia Crupi, Hedi Mansour, Giuseppa Di Bella. Monitoring of Environmental Hg Occurrence in Tunisian Coastal Areas. International Journal of Environmental Research and Public Health. 2021; 18 (10):5202.

Chicago/Turabian Style

Amel Jebara; Vincenzo Lo Turco; Caterina Faggio; Patrizia Licata; Vincenzo Nava; Angela Potortì; Rosalia Crupi; Hedi Mansour; Giuseppa Di Bella. 2021. "Monitoring of Environmental Hg Occurrence in Tunisian Coastal Areas." International Journal of Environmental Research and Public Health 18, no. 10: 5202.

Research article
Published: 06 May 2021 in Environmental Science and Pollution Research
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The purpose of this study was to evaluate the short-term irrigation effect with industrial poultry wastewater on young olive trees (Olea europaea L. cv. Chemlali). Industrial poultry wastewater can be considered as a bio-fertilizer due to its richness in nutritive elements (SO42−, HCO3−, total nitrogen, and K+). The physicochemical analysis of wastewater showed a high concentration of TSS, COD, BOD, COT, NO3−, and conductivity. Measurements indicated that poultry wastewater enhanced plant growth, leaves dry matter, and ashes in comparison with tap water, as well as poultry wastewater diluted with tap water; however, a decrease in total soluble sugars (glucose and fructose) was detected in leaves. The determination of fatty acid profile of young olive trees leaves irrigated with poultry wastewater showed richness on saturated fatty acids in comparison with mono- and poly-unsaturated ones. In addition, oleic acid (C18:1) presented the lowest content in leaves of trees irrigated with poultry wastewater irrigation. According to those results, poultry wastewater lends itself to being a hydric alternative and at the same time a source of nutrients that can help fill the water deficit in semi-arid countries and avoid costly waste disposal for slaughterhouses.

ACS Style

Amira Oueslati; Giuseppe Montevecchi; Andrea Antonelli; Hedi Ben Mansour. Short-time irrigation on young olive tree (Olea europaea L. cv. Chemlali) with untreated industrial poultry wastewater: investigation of growth parameters and leaves chemical composition. Environmental Science and Pollution Research 2021, 1 -10.

AMA Style

Amira Oueslati, Giuseppe Montevecchi, Andrea Antonelli, Hedi Ben Mansour. Short-time irrigation on young olive tree (Olea europaea L. cv. Chemlali) with untreated industrial poultry wastewater: investigation of growth parameters and leaves chemical composition. Environmental Science and Pollution Research. 2021; ():1-10.

Chicago/Turabian Style

Amira Oueslati; Giuseppe Montevecchi; Andrea Antonelli; Hedi Ben Mansour. 2021. "Short-time irrigation on young olive tree (Olea europaea L. cv. Chemlali) with untreated industrial poultry wastewater: investigation of growth parameters and leaves chemical composition." Environmental Science and Pollution Research , no. : 1-10.

Research article
Published: 06 May 2021 in Environmental Science and Pollution Research
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In this study, 18 plasticizer (phthalates, adipates, sebacates, and others) residues in sixteen medicines available in Tunisian pharmaceutical markets are evaluated by MSPD combined with GC-MS. In parallel, in this research, UPLC-MS/MS technique was performed to detect bisphenol A, and cadmium, lead, chromium, cobalt, nickel, mercury, selenium, and arsenic levels were determined by ICP-MS. The maximum daily ingested mass of mineral elements was calculated and compared with permissible daily exposure limits published by USP NF 2013. Our results demonstrated that the 50% of drugs contained similar concentrations of di-ethyl adipate. Di-isobutyl phthalate was found in a single sample with a high concentration (1.07mgkg-1). Di-methyladipate was also present in only one sample. Diethyl phthalate was detected in three medicines: the highest concentration (17.03mgkg-1) was found in capsules. The other plasticizers and bisphenol A levels were below the limits of quantification in the all samples. All tested products were safe for use, except two clay-originated products. Concentrations and the maximum daily ingested mass of lead and arsenic were higher than recommended limits. The use of these medicines should require more attention taking into account the serious hazards of heavy metals to human health.

ACS Style

Asma Beltifa; Sana Alibi; Vincenzo Lo Turco; Hedi Ben Mansour; Giuseppa Di Bella. Identification and quantification of plasticizers, bisphenol, and environmental toxic mineral elements residues in medicines from Tunisian markets. Environmental Science and Pollution Research 2021, 1 -9.

AMA Style

Asma Beltifa, Sana Alibi, Vincenzo Lo Turco, Hedi Ben Mansour, Giuseppa Di Bella. Identification and quantification of plasticizers, bisphenol, and environmental toxic mineral elements residues in medicines from Tunisian markets. Environmental Science and Pollution Research. 2021; ():1-9.

Chicago/Turabian Style

Asma Beltifa; Sana Alibi; Vincenzo Lo Turco; Hedi Ben Mansour; Giuseppa Di Bella. 2021. "Identification and quantification of plasticizers, bisphenol, and environmental toxic mineral elements residues in medicines from Tunisian markets." Environmental Science and Pollution Research , no. : 1-9.

Journal article
Published: 04 May 2021 in Journal of Water and Health
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Hospital effluent (HE) is one of the most important sources of pharmaceuticals released into the environment. This kind of pollution is a recognized problem for both human health and aquatic life. Consequently, in the present study, we assessed the effects of untreated hospital effluent on mice via biochemical and histopathological determinations. Female mice were given free access to water bottles containing untreated HE at different dilutions for 21 days. Then clinical biochemistry and histopathology evaluation were conducted. Serum biochemistry analysis showed the presence of significant increase in cholesterol, triglycerides, glycaemia and total bilirubin. However, phosphatase alkaline and urea activities have been significantly decreased compared to the control group. No significant variation was observed for the rest of the studied parameters (high-density lipoproteins; low-density lipoproteins and uric acid). Additionally, multiple alterations, including cellular necrosis, leucocyte infiltration and congestion, were observed in different tissues of mice exposed to the tested HE.

ACS Style

Sabrine Afsa; Ons Fekih Sallem; Nouha Ben Abdeljelil; Anouar Feriani; Mohamed Fadhel Najjar; Hedi Ben Mansour. In vivo toxicities of the hospital effluent in Mahdia Tunisia. Journal of Water and Health 2021, 19, 499 -511.

AMA Style

Sabrine Afsa, Ons Fekih Sallem, Nouha Ben Abdeljelil, Anouar Feriani, Mohamed Fadhel Najjar, Hedi Ben Mansour. In vivo toxicities of the hospital effluent in Mahdia Tunisia. Journal of Water and Health. 2021; 19 (3):499-511.

Chicago/Turabian Style

Sabrine Afsa; Ons Fekih Sallem; Nouha Ben Abdeljelil; Anouar Feriani; Mohamed Fadhel Najjar; Hedi Ben Mansour. 2021. "In vivo toxicities of the hospital effluent in Mahdia Tunisia." Journal of Water and Health 19, no. 3: 499-511.

Research article
Published: 16 April 2021 in Water Environment Research
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The aim of this study is to determine physiochemical and bacteriological properties of seawater and sediments from the coast of Tunisia during six successive months. The conductivity was measured using previously calibrated Hach Conductivity meter. Total suspended solid was determined using Whatman GF/C glass fiber filter (Sigma Aldrich), and the turbidity was assessed using a spectrophotometer (UV/Vis). The pH was measured using pH electrodes. Other physiochemical parameters were determined using Pastel UV multiparameter water analyzer (Secomam, aqualabo). Bacterial analysis was displayed by membrane filtration method, and isolates were identified to the species level by Api strips. Susceptibility to antibiotics was determined by disk diffusion methods. Total suspended solid, turbidity, adsorbable organic halogen, chemical oxygen demand, and biochemical oxygen demand were higher than accepted norms in Tunisia. Enterococcus faecalis was detected in all the sites indicating a human fecal contamination, and all the isolates were highly resistant to rifampicin, gentamicin, chloramphenicol, ampicillin, and azithromycin. The situation in Mahdia coast is alarming particularly with the isolation of multidrug resistance strains. It is recommended that the local government provide restrict policies for the treatment and the assessment of municipal wastewater before its discharge into sea. Practitioner points Coastal Surveillance and Water Quality monitoring in the Rejiche Sea – Tunisia is crucial. Enterococcus faecalis was detected in sea water and sediment samples in the coast of Rejiche. Isolated strains were highly resistant to rifampicin, gentamicin, chloramphenicol, ampicillin and azithromycin.

ACS Style

Sana Alibi; Asma Beltifa; Wafa Hassen; Ahlem Jaziri; Lotfi Soussia; Fairouz Zbidi; Hedi Ben Mansour. Coastal Surveillance and Water Quality monitoring in the Rejiche Sea—Tunisia. Water Environment Research 2021, 1 .

AMA Style

Sana Alibi, Asma Beltifa, Wafa Hassen, Ahlem Jaziri, Lotfi Soussia, Fairouz Zbidi, Hedi Ben Mansour. Coastal Surveillance and Water Quality monitoring in the Rejiche Sea—Tunisia. Water Environment Research. 2021; ():1.

Chicago/Turabian Style

Sana Alibi; Asma Beltifa; Wafa Hassen; Ahlem Jaziri; Lotfi Soussia; Fairouz Zbidi; Hedi Ben Mansour. 2021. "Coastal Surveillance and Water Quality monitoring in the Rejiche Sea—Tunisia." Water Environment Research , no. : 1.

Preprint content
Published: 07 April 2021
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The purpose of this study was to evaluate the short-term irrigation effect with industrial poultry wastewater on young olive trees (Olea europaea L. cv. Chemlali). Industrial poultry wastewater can be considered as a bio-fertilizer due to its richness in nutritive elements (SO4 2−, HCO3 −, total nitrogen and K+). The physico-chemical analysis of wastewater showed a high concentration of TSS, COD, BOD, COT, NO3 −, and conductivity. Measurements indicated that poultry wastewater enhanced plant growth, leaves dry matter, and ashes in comparison with tap water, as well as poultry wastewater diluted with tap water, however, a decrease in total soluble sugars (glucose and fructose) was detected in leaves. The determination of fatty acid profile of young olive trees leaves irrigated with poultry wastewater showed richness on saturated fatty acids in comparison with mono- and poly-unsaturated ones. In addition, oleic acid (C18:1) presented the lowest content in leaves of trees irrigated with poultry wastewater irrigation. According to those results, poultry wastewater lends itself to being a hydric alternative and at the same time a source of nutrients that can help fill the water deficit in semi-arid countries and avoid costly waste disposal for slaughterhouses.

ACS Style

Amira Oueslati; Giuseppe Montevecchi; Andrea Antonelli; Hedi Ben Mansour. Effect of short-time irrigation with industrial poultry wastewater on young olive tree (Olea europaea L. cv. Chemlali) growth parameters and the chemical composition of leaves. 2021, 1 .

AMA Style

Amira Oueslati, Giuseppe Montevecchi, Andrea Antonelli, Hedi Ben Mansour. Effect of short-time irrigation with industrial poultry wastewater on young olive tree (Olea europaea L. cv. Chemlali) growth parameters and the chemical composition of leaves. . 2021; ():1.

Chicago/Turabian Style

Amira Oueslati; Giuseppe Montevecchi; Andrea Antonelli; Hedi Ben Mansour. 2021. "Effect of short-time irrigation with industrial poultry wastewater on young olive tree (Olea europaea L. cv. Chemlali) growth parameters and the chemical composition of leaves." , no. : 1.

Journal article
Published: 29 March 2021 in Foods
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The concentrations of 19 chemical elements have been determined in 36 honey samples of different botanical (wildflower, eucalyptus, eucalyptus red flowers, prickly pears, lemon blossom, thyme, almond, rosemary and jujube) honeys from the three geographical areas of Tunisia (Sidi Bouzid, Nabeul and Sfax) using inductively coupled plasma mass spectrometry (ICP-MS). The aim of this work was to use the multielement analysis together with chemometric tools to verify the botanical and the geographical origin of honeys. The correlation on the basis of mineral element content between the honey samples and their botanical and/or geographical origins was in some measure achieved. The data collected on the samples were also used to evaluate the nutritional quality and the potential health risks associated with elements via consumption of the Tunisian honey. According to the results obtained, the intake of essential elements was small, and the potential health risks associated with toxic or potentially toxic elements via consumption of this food were overall insignificant.

ACS Style

Giuseppa Di Bella; Angela Potortì; Asma Beltifa; Hedi Ben Mansour; Vincenzo Nava; Vincenzo Lo Turco. Discrimination of Tunisian Honey by Mineral and Trace Element Chemometrics Profiling. Foods 2021, 10, 724 .

AMA Style

Giuseppa Di Bella, Angela Potortì, Asma Beltifa, Hedi Ben Mansour, Vincenzo Nava, Vincenzo Lo Turco. Discrimination of Tunisian Honey by Mineral and Trace Element Chemometrics Profiling. Foods. 2021; 10 (4):724.

Chicago/Turabian Style

Giuseppa Di Bella; Angela Potortì; Asma Beltifa; Hedi Ben Mansour; Vincenzo Nava; Vincenzo Lo Turco. 2021. "Discrimination of Tunisian Honey by Mineral and Trace Element Chemometrics Profiling." Foods 10, no. 4: 724.

Research article
Published: 27 March 2021 in Environmental Science and Pollution Research
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Dermaseptins are peptides found in the skin secretions of Phyllomedusinae frogs. These peptides exert a lytic action on various microorganisms and have no considerable hemolytic effect except dermaseptin S4 (DS4) which exhibits a powerful cytotoxic effect. Therefore, we synthesized several analogs of DS4 in an attempt to find molecules with a weak hemolytic effect and significant bioactivities. In this study, we performed the synthesis of truncated peptides by introducing C-terminal and N-terminal amino acid deletions of the native sequence. All peptide analogs, in comparison with parental peptide, were tested firstly on human red blood cells to work out their cytotoxicity, secondly on the multidrug-resistant bacteria by trying to find MICs, and finally on colon cancer tumor cell line SW620 using the MTT test so as to investigate the anti-proliferative effect. Our results showed that, on the one hand, the N terminus of the native peptide was necessary for the antibacterial activity and the anti-proliferative effect of the peptide. On the other hand, the hemolytic activity was more notable in the sequences broken down on the C-terminal side.

ACS Style

Afifa Belaid; Afef Braiek; Sana Alibi; Wafa Hassen; Asma Beltifa; Adel Nefzi; Hedi Ben Mansour. Evaluating the effect of dermaseptin S4 and its derivatives on multidrug-resistant bacterial strains and on the colon cancer cell line SW620. Environmental Science and Pollution Research 2021, 28, 40908 -40916.

AMA Style

Afifa Belaid, Afef Braiek, Sana Alibi, Wafa Hassen, Asma Beltifa, Adel Nefzi, Hedi Ben Mansour. Evaluating the effect of dermaseptin S4 and its derivatives on multidrug-resistant bacterial strains and on the colon cancer cell line SW620. Environmental Science and Pollution Research. 2021; 28 (30):40908-40916.

Chicago/Turabian Style

Afifa Belaid; Afef Braiek; Sana Alibi; Wafa Hassen; Asma Beltifa; Adel Nefzi; Hedi Ben Mansour. 2021. "Evaluating the effect of dermaseptin S4 and its derivatives on multidrug-resistant bacterial strains and on the colon cancer cell line SW620." Environmental Science and Pollution Research 28, no. 30: 40908-40916.

Journal article
Published: 20 November 2020 in Environmental Toxicology and Pharmacology
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Persistent organic and inorganic contaminants generated by industrial effluent wastes poses a threat to the maintenance of aquatic ecosystems and public health. The Khniss and Hamdoun rivers, located in the central-east of Tunisia, receive regularly domestic and textile wastewater load. The present study aimed to survey the water quality of these rivers using physicochemical, analytical and toxicological approaches. In the physicochemical analysis, the recorded levels of COD and TSS in both samples exceed the Tunisian standards. Using the analytical approach, several metals and some textile dyes were detected. Indeed, 17 metals were detected in both samples in varying concentrations, which do not exceed the Tunisian standards. The sources of metals pollution can be of natural and anthropogenic origin. Three textile disperse dyes were detected with high levels compared to other studies: the disperse orange 37 was detected in the Khniss river with a concentration of 6.438 µg/L and the disperse red 1 and the disperse yellow 3 were detected in the Hamdoun river with concentrations of 3.873 µg/L and 1,895 µg/L, respectively. Textile activities were the major sources of disperse dyes. For both samples, acute and chronic ecotoxicity was observed in all the studied organisms, however, no genotoxic activity was detected. The presence of metals and textile disperse dyes could be associated with the ecotoxicological effects observed in the river waters, in particular due to the industrial activity, a fact that could deteriorate the ecosystem and therefore threaten the human health of the population living in the study areas. Combining chemical and biological approaches, allowed the detection of water ecotoxicity in testing organisms and the identification of possible contributors to the toxicity observed in these multi-stressed water reservoirs.

ACS Style

Nosra Methneni; José Antonio Morales González; Joris Van Loco; Roel Anthonissen; Jolien Van de Maele; Luc Verschaeve; Mercedes Fernandez-Serrano; Hedi Ben Mansour. Ecotoxicity profile of heavily contaminated surface water of two rivers in Tunisia. Environmental Toxicology and Pharmacology 2020, 82, 103550 .

AMA Style

Nosra Methneni, José Antonio Morales González, Joris Van Loco, Roel Anthonissen, Jolien Van de Maele, Luc Verschaeve, Mercedes Fernandez-Serrano, Hedi Ben Mansour. Ecotoxicity profile of heavily contaminated surface water of two rivers in Tunisia. Environmental Toxicology and Pharmacology. 2020; 82 ():103550.

Chicago/Turabian Style

Nosra Methneni; José Antonio Morales González; Joris Van Loco; Roel Anthonissen; Jolien Van de Maele; Luc Verschaeve; Mercedes Fernandez-Serrano; Hedi Ben Mansour. 2020. "Ecotoxicity profile of heavily contaminated surface water of two rivers in Tunisia." Environmental Toxicology and Pharmacology 82, no. : 103550.

Research article
Published: 19 November 2020 in Environmental Science and Pollution Research
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Medicines and drugs consumption by all populations of the world can be expected to result in the contamination of the environment since 30–90% of residual drugs will be found into wastewaters. In this study, we investigate the degradation of acetaminophen, selected as a xenobiotic model molecule, via two separate procedures, the TiO2 impregnated on cellulosic paper photocatalysis, and specific bacterial biodegradation process. Results showed that for initial drug content of 400 mg/L and after 5 hours of processing, around 85% of paracetamol was photocatalytically degraded. The use of Pseudomonas putida E1.21 isolate allowed an abatement of around 92% after 32 h of processing. The acetaminophen toxicity conducted in vivo on laboratory mice showed a net decrease of the creatinine release and enzymes activities like ALP, ALT, AST, and LDH decreased significantly (p < 0.05) when mice were treated distinctly by acetaminophen treated with UV/TiO2 and the Pseudomonas putida E1.21 strain compared with the control experiments. CAT, MDA, and AchE serum level disruption measurement indicated a serious affection of the mice antioxidant system. These results were found to be in correlation with the ones of the histological analysis of the liver and kidney.

ACS Style

Ikram Rouibah; Wafa Hassen; Ons Fekih Sallem; Nabila Khellaf; Abdennaceur Hassen; Hedi Ben Mansour. Photocatalytic and biodegradation treatments of paracetamol: investigation of the in vivo toxicity. Environmental Science and Pollution Research 2020, 28, 14530 -14545.

AMA Style

Ikram Rouibah, Wafa Hassen, Ons Fekih Sallem, Nabila Khellaf, Abdennaceur Hassen, Hedi Ben Mansour. Photocatalytic and biodegradation treatments of paracetamol: investigation of the in vivo toxicity. Environmental Science and Pollution Research. 2020; 28 (12):14530-14545.

Chicago/Turabian Style

Ikram Rouibah; Wafa Hassen; Ons Fekih Sallem; Nabila Khellaf; Abdennaceur Hassen; Hedi Ben Mansour. 2020. "Photocatalytic and biodegradation treatments of paracetamol: investigation of the in vivo toxicity." Environmental Science and Pollution Research 28, no. 12: 14530-14545.

Research article
Published: 30 May 2020 in International Journal of Environmental Health Research
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For several years, environmental exogenous agents, called endocrine disruptors, are suspected to interfere with the essential functions of reproduction and development in many living organisms. In this study, endocrine disruptors including five phthalates and two bisphenols contents in finished products were assayed and their estrogenic activity were measured by using the Yeast Estrogen Screen system with respect to human and trout estrogen receptors hERα and rtERS. Independently of the estrogen receptor, only short-chain phthalates (DBP and BBP) and the two bisphenols exhibited an estrogenic activity. Besides, the risk of three end-products (agro-food, cosmetics, and pharmaceutical) was evaluated before and after forced aging. Only two cosmetics the face cream and the perfume presented a hazard which increases with aging. These results are consistent with the compounds identified by Gas chromatography-mass spectrometry. These findings confirmed that the YES system can be routinely used to evaluate the estrogenic hazards within finished products.

ACS Style

Manel Chebbi; Asma Beltifa; Sana Alibi; Giuseppa Di Bella; Vincenzo LoTurco; Olivier Sire; Hedi Ben Mansour; Véronique Le Tilly. Estrogenic hazards of short chain phthalates and bisphenols found in cosmetic products. International Journal of Environmental Health Research 2020, 1 -12.

AMA Style

Manel Chebbi, Asma Beltifa, Sana Alibi, Giuseppa Di Bella, Vincenzo LoTurco, Olivier Sire, Hedi Ben Mansour, Véronique Le Tilly. Estrogenic hazards of short chain phthalates and bisphenols found in cosmetic products. International Journal of Environmental Health Research. 2020; ():1-12.

Chicago/Turabian Style

Manel Chebbi; Asma Beltifa; Sana Alibi; Giuseppa Di Bella; Vincenzo LoTurco; Olivier Sire; Hedi Ben Mansour; Véronique Le Tilly. 2020. "Estrogenic hazards of short chain phthalates and bisphenols found in cosmetic products." International Journal of Environmental Health Research , no. : 1-12.

Journal article
Published: 14 April 2020 in Agricultural Water Management
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The present work aimed to study the effect of using Treated Wastewater (TWW) to irrigate Chemlali olive trees on the quality characteristics and chemical composition of olive oils. This research was conducted in orchards cultivated in the center of Tunisia where olive trees were subjected to different irrigation treatments during two consecutive years; (CT) 0 % ETc, (T1) 20 % ETc and (T2) 40 % ETc. Results showed that irrigation with TWW whatever the level didn’t significantly affect oil standard quality indices (free acidity, K232, K270 and peroxide value) and pigment contents. Furthermore, α-tocopherol amount was maintained stable which may explain the preservation of fatty acids against oxidation after TWW irrigation. Moreover, this last did not induce phenolic compounds contents variation. A decrease of some volatile compounds giving oil undesirable attributes (octanal and acetic acid) and a maintain of those offering good characteristics like the fruity odor were observed.

ACS Style

Wiem Sdiri; Samia Dabbou; Hechmi Chehab; Roberto Selvaggini; Maurizio Servili; Giuseppa Di Bella; Hedi Ben Mansour. Quality characteristics and chemical evaluation of Chemlali olive oil produced under dairy wastewater irrigation. Agricultural Water Management 2020, 236, 106124 .

AMA Style

Wiem Sdiri, Samia Dabbou, Hechmi Chehab, Roberto Selvaggini, Maurizio Servili, Giuseppa Di Bella, Hedi Ben Mansour. Quality characteristics and chemical evaluation of Chemlali olive oil produced under dairy wastewater irrigation. Agricultural Water Management. 2020; 236 ():106124.

Chicago/Turabian Style

Wiem Sdiri; Samia Dabbou; Hechmi Chehab; Roberto Selvaggini; Maurizio Servili; Giuseppa Di Bella; Hedi Ben Mansour. 2020. "Quality characteristics and chemical evaluation of Chemlali olive oil produced under dairy wastewater irrigation." Agricultural Water Management 236, no. : 106124.

Journal article
Published: 04 January 2020 in International Journal of Chemical Reactor Engineering
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The Heterogeneous photocatalysis, increasingly used in effluent purification, is attracting more and more attention by the development of new photocatalytic materials based on semiconductors deposited on various supports. In this work, TiO2 supported on cellulosic fiber was prepared and characterized by different analytical techniques such as X-ray Photoelectron Spectrometry and Brunauer-Emmett-Teller surface area. Its photocatalytic activity was investigated for the degradation of Solophenyl Scarlet BNLE (SS), an organic pollutant present in textile effluents. Several conditions were investigated such as adsorption under UV and visible irradiation, catalyst recyclability, the simulated effluent pH and the presence of H2O2 as an oxidant agent. Results showed that under UV light, the removal of SS decreased significantly with increasing initial dye concentration. For an initial concentration of 5 mg/L, SS degradation was reached more than 95 % after 2 hours of treatment (neutral pH, T = 20 °C). The supported TiO2 on cellulose remains effective over four cycles of dye treatment. In the presence of H2O2, the degradation process was inhibited with increasing the molar ratio [H2O2]/[SS]0 from 5 to 30. The kinetic modeling showed that the removal of this pollutant followed a pseudo-first-order model (Langmuir-Hinshelwood) with a regression coefficient (R2) value of 0.984.

ACS Style

Ikram Rouibah; Hichem Zeghioud; Nabila Khellaf; Amine Assadi Aymen; Hédi Benmansour; Hayet Djelal; Abdeltif Amrane. Intensified Photocatalytic Degradation of Solophenyl Scarlet BNLE in Simulated Textile Effluents Using TiO2 Supported on Cellulosic Tissue. International Journal of Chemical Reactor Engineering 2020, 18, 1 .

AMA Style

Ikram Rouibah, Hichem Zeghioud, Nabila Khellaf, Amine Assadi Aymen, Hédi Benmansour, Hayet Djelal, Abdeltif Amrane. Intensified Photocatalytic Degradation of Solophenyl Scarlet BNLE in Simulated Textile Effluents Using TiO2 Supported on Cellulosic Tissue. International Journal of Chemical Reactor Engineering. 2020; 18 (2):1.

Chicago/Turabian Style

Ikram Rouibah; Hichem Zeghioud; Nabila Khellaf; Amine Assadi Aymen; Hédi Benmansour; Hayet Djelal; Abdeltif Amrane. 2020. "Intensified Photocatalytic Degradation of Solophenyl Scarlet BNLE in Simulated Textile Effluents Using TiO2 Supported on Cellulosic Tissue." International Journal of Chemical Reactor Engineering 18, no. 2: 1.

Journal article
Published: 31 December 2019 in Journal of Water and Health
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Hospitals' effluents contain a considerable amount of chemicals. Considering the significant volume of wastewater discharged by hospitals, the presence of these chemicals represents a real threat to the environment and human health. Thus, the aim of this study was to evaluate the in vivo and in vitro genotoxicities of three wastewater effluents collected from Tunisian hospitals. The liver of Swiss albino male mice, previously treated with different doses of the hospital wastewaters, was used as a model to detect DNA fragmentation. Our results showed all the hospital effluents caused significant qualitative and quantitative hazards in hepatic DNA. The wastewater collected from Sfax hospital exhibited the highest genotoxic effect, which may be explained by the presence in this effluent of some toxic micropolluants. There was a significant increase in genotoxicity, proportionally to the concentration of effluent. However, the vitotox assay did not show any significant genotoxicity on Salmonella typhimurium TA104 in the presence or absence of microsomal fraction S9. The ratio gentox/cytox was lower than the threshold 1.5. This study assessed the toxicological risk issued from Tunisian hospital wastewaters, which is potentially very harmful, and it has been pointed out that wastewater treatment requires special attention.

ACS Style

Asma Beltifa; Sana Alibi; Hedi Ben Mansour. Monitoring hospital wastewaters for their probable genotoxicity. Journal of Water and Health 2019, 18, 1 -7.

AMA Style

Asma Beltifa, Sana Alibi, Hedi Ben Mansour. Monitoring hospital wastewaters for their probable genotoxicity. Journal of Water and Health. 2019; 18 (1):1-7.

Chicago/Turabian Style

Asma Beltifa; Sana Alibi; Hedi Ben Mansour. 2019. "Monitoring hospital wastewaters for their probable genotoxicity." Journal of Water and Health 18, no. 1: 1-7.

Research article
Published: 25 November 2019 in Environmental Science and Pollution Research
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In the present study, the occurrence of 40 pharmaceuticals belonging to several therapeutic groups was investigated for the first time in hospital effluent, wastewater treatment plant influent and effluent, and seawater in Mahdia, Tunisia. Forty-six samples were collected within a 6-month sampling period. Pharmaceuticals were analyzed using solid-phase extraction followed by ultra-performance liquid chromatography-triple quadrupole mass spectrometry. Thirty-three out of the forty target compounds were detected over a wide concentration of ranges, from nanograms per liter to micrograms per liter, depending on the type of sample. Maximum values were detected for caffeine at 902 μgL−1 in hospital wastewater. This compound, as well as salicylic acid, sulfadiazine, and sulfamethizole, were detected in all samples. The average concentration of total pharmaceuticals in hospital wastewater (340 μgL−1) was higher than those detected in influent and effluent wastewater and seawater (275.11 and 0.2 μgL−1, respectively). Risk quotients (RQs) were also estimated to provide a preliminary environmental risk assessment and results revealed that sulfadiazine, sulfamethoxazole, and fluoxetine could pose medium/high risk to the tested aquatic organisms for maximum measured concentrations in wastewater (including hospital and WWTP samples). Although the measured environmental concentrations (MECs) detected in seawater samples might not pose a toxic effect to the aquatic organisms (except for salicylic acid, sulfamethoxazole and fluoxetine), further researches are needed due to the continuous release of wastewater in the environment and the limited efficiency of wastewater treatment processes.

ACS Style

Sabrine Afsa; Khaled Hamden; Pablo A Lara Martin; Hedi Ben Mansour. Occurrence of 40 pharmaceutically active compounds in hospital and urban wastewaters and their contribution to Mahdia coastal seawater contamination. Environmental Science and Pollution Research 2019, 27, 1941 -1955.

AMA Style

Sabrine Afsa, Khaled Hamden, Pablo A Lara Martin, Hedi Ben Mansour. Occurrence of 40 pharmaceutically active compounds in hospital and urban wastewaters and their contribution to Mahdia coastal seawater contamination. Environmental Science and Pollution Research. 2019; 27 (2):1941-1955.

Chicago/Turabian Style

Sabrine Afsa; Khaled Hamden; Pablo A Lara Martin; Hedi Ben Mansour. 2019. "Occurrence of 40 pharmaceutically active compounds in hospital and urban wastewaters and their contribution to Mahdia coastal seawater contamination." Environmental Science and Pollution Research 27, no. 2: 1941-1955.

Research article
Published: 19 December 2017 in Environmental Science and Pollution Research
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Clinical evidences, experimental models, and epidemiology of many studies suggest that phthalate-based plasticizers, aliphatic ester, and bisphenol A (BPA) have major risks for humans by targeting different organs and body systems. The current study has been designed firstly to analyze three categories of cheese with and without their exposure to the sun and packed in packages with an inner surface plastic-covered film in order to identify the dibutyl phthalate (DBP); benzyl butyl phthalate (BBP); bis(2-ethylhexyl) phthalate (DEHP); diisodecyl phthalate (DiDP); diisononyl phthalate (DiNP); and 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) by GC-MS/MS, except for the bisphenol A, which is by UPLC-MS/MS, and secondly to assess the toxicity of the identified chemical molecules and cheese samples on the liver and kidney of mice. Our results showed that the cheese contains high quantities of DBP and DEHP with the concentrations up to 0.46 and 2.339 mg/kg, respectively. Other types of cheese, such as rolled and triangular cheeses, contain little quantities of the all substances at concentrations below the standard limits. In vivo, the obtained data clearly demonstrated that the acute administration of DBP, DEHP, and the tested cheese significantly induced liver and kidney injuries in mice manifested by a rise in plasma alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, lactate dehydrogenase, urea, creatinine, and uric acid when compared with control animals. In addition, the histopathological study confirmed the perturbation of biochemical parameters and showed that the hepatic and renal structures were altered. Indeed, the hepatotoxic and nephrotoxic effects are more pronounced when cheese was exposed to the sun.

ACS Style

Asma Beltifa; Anouar Feriani; Monia Macherki; Asma Ghorbel; Lakhdar Ghazouani; Giuseppa Di Bella; Olivier Sire; Joris Van Loco; Tim Reyns; Hedi Ben Mansour. Persistent plasticizers and bisphenol in the cheese of Tunisian markets induced biochemical and histopathological alterations in male BALB/c mice. Environmental Science and Pollution Research 2017, 25, 6545 -6557.

AMA Style

Asma Beltifa, Anouar Feriani, Monia Macherki, Asma Ghorbel, Lakhdar Ghazouani, Giuseppa Di Bella, Olivier Sire, Joris Van Loco, Tim Reyns, Hedi Ben Mansour. Persistent plasticizers and bisphenol in the cheese of Tunisian markets induced biochemical and histopathological alterations in male BALB/c mice. Environmental Science and Pollution Research. 2017; 25 (7):6545-6557.

Chicago/Turabian Style

Asma Beltifa; Anouar Feriani; Monia Macherki; Asma Ghorbel; Lakhdar Ghazouani; Giuseppa Di Bella; Olivier Sire; Joris Van Loco; Tim Reyns; Hedi Ben Mansour. 2017. "Persistent plasticizers and bisphenol in the cheese of Tunisian markets induced biochemical and histopathological alterations in male BALB/c mice." Environmental Science and Pollution Research 25, no. 7: 6545-6557.

Original paper
Published: 11 December 2017 in Archives of Microbiology
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The UPLC MS/MS analysis showed the presence of the two antibiotics in the pharmaceutical industry discharges during 3 months; norfloxacin and spiramycin which were quantified with the mean concentrations of 226.7 and 84.2 ng mL−1, respectively. Sixteen resistant isolates were obtained from the pharmaceutical effluent and identified by sequencing. These isolates belong to different genera, namely Citrobacter, Acinetobacter, Pseudomonas, Delftia, Shewanella, and Rheinheimera. The antibiotic resistance phenotypes of these isolates were determined (27 tested antibiotics-discs). All the studied isolates were found resistant to amoxicillin and gentamicin, and 83.33% of isolates were resistant to ciprofloxacin. Multiple antibiotic resistances were revealed against β-lactams, quinolones, and aminoglycosides families. Our overall results suggest that the obtained bacterial isolates may constitute potential candidates for bioremediation and can be useful for biotechnological applications. Genotoxic effects were assessed by a battery of biotests; the pharmaceutical wastewater was genotoxic according to the bacterial Vitotox test and micronuclei test. Genotoxicity was also evaluated by the comet test; the tail DNA damages reached 38 and 22% for concentrated sample (10×) and non-concentrated sample (1×), respectively. However, the histological sections of kidney and liver’s mice treated by pharmaceutical effluent showed normal histology and no visible structural effects or alterations as cytolysis, edema, or ulcerative necrosis were observed. Residual antibiotics can reach water environment through wastewater and provoke dissemination of the antibiotics resistance and induce genotoxic effects.

ACS Style

Leyla Tahrani; Ines Mehri; Tim Reyns; Roel Anthonissen; Luc Verschaeve; Anis Bel Haj Khalifa; Joris Van Loco; Hassen Abdenaceur; Hedi Ben Mansour. UPLC-MS/MS analysis of antibiotics in pharmaceutical effluent in Tunisia: ecotoxicological impact and multi-resistant bacteria dissemination. Archives of Microbiology 2017, 200, 553 -565.

AMA Style

Leyla Tahrani, Ines Mehri, Tim Reyns, Roel Anthonissen, Luc Verschaeve, Anis Bel Haj Khalifa, Joris Van Loco, Hassen Abdenaceur, Hedi Ben Mansour. UPLC-MS/MS analysis of antibiotics in pharmaceutical effluent in Tunisia: ecotoxicological impact and multi-resistant bacteria dissemination. Archives of Microbiology. 2017; 200 (4):553-565.

Chicago/Turabian Style

Leyla Tahrani; Ines Mehri; Tim Reyns; Roel Anthonissen; Luc Verschaeve; Anis Bel Haj Khalifa; Joris Van Loco; Hassen Abdenaceur; Hedi Ben Mansour. 2017. "UPLC-MS/MS analysis of antibiotics in pharmaceutical effluent in Tunisia: ecotoxicological impact and multi-resistant bacteria dissemination." Archives of Microbiology 200, no. 4: 553-565.

Journal article
Published: 01 October 2017 in Environmental Pollution
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Carbapenems are β-lactam antibiotics with a broad spectrum of activity and are usually considered the last resort for the treatment of severe infections caused by multidrug-resistant pathogens. The clinically most significant carbapenemases are KPC, NDM, and OXA-48-like enzymes, whose genes have been increasingly reported worldwide in members of the family Enterobacteriaceae. In this study, we quantified the abundance of these genes in wastewater effluents from different Tunisian hospitals. The bla and bla-like genes were detected at similar concentrations in all hospital wastewater effluents. In contrast, the bla gene was detected at lower concentration than other genes and it was only detected in three of the seven effluents analyzed. To the best of our knowledge, this study quantified for the first time the abundance of bla, bla, and bla-like genes in wastewater effluents from Tunisian hospitals, highlighting the widespread distribution of these carbapenemase genes.

ACS Style

Emna Nasri; Jessica Subirats; Alexandre Sànchez-Melsió; Hedi Ben Mansour; Carles M. Borrego; José Luis Balcázar. Abundance of carbapenemase genes (blaKPC, blaNDM and blaOXA-48) in wastewater effluents from Tunisian hospitals. Environmental Pollution 2017, 229, 371 -374.

AMA Style

Emna Nasri, Jessica Subirats, Alexandre Sànchez-Melsió, Hedi Ben Mansour, Carles M. Borrego, José Luis Balcázar. Abundance of carbapenemase genes (blaKPC, blaNDM and blaOXA-48) in wastewater effluents from Tunisian hospitals. Environmental Pollution. 2017; 229 ():371-374.

Chicago/Turabian Style

Emna Nasri; Jessica Subirats; Alexandre Sànchez-Melsió; Hedi Ben Mansour; Carles M. Borrego; José Luis Balcázar. 2017. "Abundance of carbapenemase genes (blaKPC, blaNDM and blaOXA-48) in wastewater effluents from Tunisian hospitals." Environmental Pollution 229, no. : 371-374.

Journal article
Published: 24 August 2017 in Water Science and Technology
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In the following study, we came up with and validated a prompt, sensitive and precise method for the simultaneous determination of 56 antimicrobial drugs (tetracyclines, sulfonamides, β-lactams, macrolides and quinolones) using the ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). This method was implemented with success to determine antibiotics in samples collected from four wastewater treatment plants and five coasts in Tunisia. Results showed the presence of high concentrations of antibiotics that ranged from 0.1 to 646 ng mL−1, which can induce many negative impacts on health and the environment. For this reason, we have opted to evaluate toxicity of wastewater samples using a battery of biotests. In fact, genotoxicity was assessed using three tests: Vitotox, comet and micronucleus assays. The input and output of wastewater treatment plants induced a strongly genotoxic effect on the Salmonella typhimurium TA104 prokaryotic Vitotox assay. This result was confirmed using the comet and the micronucleus assays performed on the human liver hepatocellular carcinoma cells. The genotoxic power of the tested wastewater treatment plants' samples could be attributed to the presence of the higher quantities of antibiotics that are detected in these samples and to the antibiotic and organic compound cocktails.

ACS Style

Leyla Tahrani; Joris Van Loco; Roel Anthonissen; Luc Verschaeve; Hedi Ben Mansour; Tim Reyns. Identification and risk assessment of human and veterinary antibiotics in the wastewater treatment plants and the adjacent sea in Tunisia. Water Science and Technology 2017, 76, 3000 -3021.

AMA Style

Leyla Tahrani, Joris Van Loco, Roel Anthonissen, Luc Verschaeve, Hedi Ben Mansour, Tim Reyns. Identification and risk assessment of human and veterinary antibiotics in the wastewater treatment plants and the adjacent sea in Tunisia. Water Science and Technology. 2017; 76 (11):3000-3021.

Chicago/Turabian Style

Leyla Tahrani; Joris Van Loco; Roel Anthonissen; Luc Verschaeve; Hedi Ben Mansour; Tim Reyns. 2017. "Identification and risk assessment of human and veterinary antibiotics in the wastewater treatment plants and the adjacent sea in Tunisia." Water Science and Technology 76, no. 11: 3000-3021.

Research article
Published: 12 August 2017 in Environmental Science and Pollution Research
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Today, processed and packaged foods are considered as among the major sources of human exposure to plasticizers and bisphenol which migrate from plastic packing. In the present study, a wide range of food products sold on the Tunisian market such as grain and grain products, milk and dairy products, fats and oil, drink, fish, and sweets have been analyzed firstly in order to identify the presence of phthalates and bisphenol. Then, the identified chemical molecules were studied for their environmental fate and tested in vivo for its toxicity in mice models. The food products analyzed using GC-MS/MS indicated the presence of the benzyl butyl phthalate (BBP), dibutyl phthalate (DBP), bis(2-ethylhexyl) phthalate (DEHP), diisodecyl phthalate (DiDP), diisononyl phthalate (DiNP), and 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINC) and which using UPLC-MS/MS demonstrated the presence of bisphenol A of all food products. However, compared to other phthalates, BBP was found at high concentrations in the puff pastry (123 mg/kg), milk (2.59 mg/kg), butter (1.5 mg/kg), yogurt (2.23 mg/kg), oil (6.94 mg/kg), water (0.57 mg/kg), candy 1 (2.35 mg/kg), candy 2 (0.81 mg/kg), orange juice (1.25 mg/kg), peach juice (1.26 mg/kg), fruit juices (0.4 mg/kg), and chocolate (0.884 mg/kg). The obtained data in vivo clearly showed that the acute administration of BBP caused hepatic and renal damage as demonstrated by an increase in biochemical parameters as well as the activities of plasma marker enzymes such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, blood urea nitrogen, glucose, urea, creatinine, and uric acid when compared to the control group. By the same occurrence, the histopathological study revealed that BBP strongly modified the structure of hepatic and renal tissues. In addition, the plasticizers and BBP will therefore discharge via wastewater treatment plants in aquatic system and could reach marine organisms such as fish. We have followed the fate of BBP in bream Sparus aurata. In fact, chemical analysis showed the contamination of wild S. aurata by BBP from Sousse Coast (1.5 mg/kg) and wild S. aurata from Monastir Coast (0.33 mg/kg).

ACS Style

Asma Beltifa; Anouar Feriani; Monia Machreki; Asma Ghorbel; Lakhdar Ghazouani; Giuseppa Di Bella; Joris Van Loco; Tim Reyns; Hedi Ben Mansour. Plasticizers and bisphenol A, in packaged foods sold in the Tunisian markets: study of their acute in vivo toxicity and their environmental fate. Environmental Science and Pollution Research 2017, 24, 22382 -22392.

AMA Style

Asma Beltifa, Anouar Feriani, Monia Machreki, Asma Ghorbel, Lakhdar Ghazouani, Giuseppa Di Bella, Joris Van Loco, Tim Reyns, Hedi Ben Mansour. Plasticizers and bisphenol A, in packaged foods sold in the Tunisian markets: study of their acute in vivo toxicity and their environmental fate. Environmental Science and Pollution Research. 2017; 24 (28):22382-22392.

Chicago/Turabian Style

Asma Beltifa; Anouar Feriani; Monia Machreki; Asma Ghorbel; Lakhdar Ghazouani; Giuseppa Di Bella; Joris Van Loco; Tim Reyns; Hedi Ben Mansour. 2017. "Plasticizers and bisphenol A, in packaged foods sold in the Tunisian markets: study of their acute in vivo toxicity and their environmental fate." Environmental Science and Pollution Research 24, no. 28: 22382-22392.