This paper presents empirical research that supports territorial approaches to tourism product development that ground tourism in science, as a mechanism to support sustainable tourism heritage conservation goals. Scientific Tourism (ST), in this context, builds on the scientific heritage of a geography, matching researchers with local actors and tourists, through a five-stage iterative process that leads to new scientific knowledge, advancing theory and building relevance for communities through socio-cultural and economic development. This article focuses on the initial stage of the ST product development process, documenting empirical research conducted within the geographies surrounding the Palena River watershed in the Aysén Region of Chilean Patagonia. Both geo-structured literature review methods and results are presented and discussed to illustrate how the outcomes, including a series of maps, can inform and ground actors’ processes of heritage resource identification, justification, conservation, and exhibition, through the development of pilot ST initiatives within the territory. Similar research approaches may prove valuable for other low-density and peripheral geographies that share an interest in grounding tourism on the science taking place within their geography.

The 1950s initiated transformative shifts in human interactions and societal behaviors, exacerbating global environmental challenges—notably, biodiversity loss. The post-2020 Kunming–Montreal Global Biodiversity Framework (GBF) addressed these challenges with ambitious plans to halt and reverse biodiversity losses. Supported by initiatives like UNESCO’s Man and the Biosphere program, the GBF seeks to enhance sustainability through country-level strategies that will mainstream nature-positive policies and expand multi-actor conservation governance. This study supports the local-level implementation of the GBF through a roadmap for the initial phase of the knowledge-action network creation. Through a case study of the Laguna San Rafael and Guayaneco Biosphere Reserve (LSRGBR) in Chilean Patagonia, this research explores the potential for inexpensive, readily available methods to support local decision makers by increasing access to and the visibility of relevant sustainability research. The study analyzes two decades of global change (GC) research within LSRGBR zones to understand spatial trends and identify applied insights with the potential to inform governance and management strategies. Findings highlight where GC research has occurred, areas of GC research interest, how applied content has manifested, and how existing research can inform and support governance action plans. Ultimately, this research proposes an adaptable knowledge mobilization framework for the LSRGBR that can be applied to a variety of place-based needs and contexts to mobilize science for broader sustainability objectives and enhance the potential for multi-actor collaboration and governance.