It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from it. This study aimed to determine ventilation practices in burn intensive care units (ICUs) and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28 (VFD-28). This is an international prospective observational cohort study including adult burn patients requiring mechanical ventilation. Low tidal volume (V_T) was defined as V_T ≤ 8 mL/kg predicted body weight (PBW). Levels of positive end-expiratory pressure (PEEP) and maximum airway pressures were collected. The association between V_T and VFD-28 was analyzed using a competing risk model. Ventilation settings were presented for all patients, focusing on the first day of ventilation. We also compared ventilation settings between patients with and without inhalation trauma. A total of 160 patients from 28 ICUs in 16 countries were included. Low V_T was used in 74% of patients, median V_T size was 7.3 [interquartile range (IQR) 6.2–8.3] mL/kg PBW and did not differ between patients with and without inhalation trauma (p = 0.58). Median VFD-28 was 17 (IQR 0–26), without a difference between ventilation with low or high V_T (p = 0.98). All patients were ventilated with PEEP levels ≥5 cmH₂O; 80% of patients had maximum airway pressures <30 cmH₂O. In this international cohort study we found that lung-protective ventilation is used in the majority of burn patients, irrespective of the presence of inhalation trauma. Use of low V_T was not associated with a reduction in VFD-28. Clinicaltrials.gov NCT02312869. Date of registration: 9 December 2014.

S of the plenary and special interest sessions, workshops, and oral and poster presentations of the 21st EBA Congress in Berlin, Germany, from 3 to 6 September 2025.