Assessment of the risk of punch-through failure of spudcan foundations on sand overlying clay requires prediction of the full penetration resistance profile, from touchdown and through punch-through to equilibrium of the vertical resistance at depth in the underlying clay layer. This study uses the Coupled Eulerian–Lagrangian approach, a large deformation finite element analysis method, to model the complete penetration resistance profile of a spudcan on sand overlying clay. The sand is modeled using the Mohr–Coulomb model, while the clay is modeled using a modified Tresca model to account for strain softening. The numerical method is then used to simulate a series of spudcan penetration tests, performed in a geotechnical centrifuge, on medium dense sand overlying clay. The punch-through behavior observed in the experiments is replicated, and the penetration resistance profiles from numerical analyses are generally a reasonable match to the experimental measurements. The influences of the sand layer height to foundation diameter ratio, sand–clay interface shear strength, and strength gradient in clay on the penetration resistance profiles are explored in a complementary parametric study. The penetration resistance in the underlying clay layer is well predicted using a simple linear expression for the bearing capacity factor for the spudcan and underlying sand plug. This expression is combined with an existing failure stress dependent model for predicting peak resistance to form a simplified method for prediction of the full penetration resistance profile. This new method provides estimates of the vertical penetration that the spudcan will run during the punch-through event. It is validated against both medium dense and dense sand centrifuge tests.

A complete analytical method to describe the full load-penetration resistance profile of a mobile jack-up spudcan footing penetrating a sand over clay stratigraphy is described. It is based on both large deformation finite-element analyses and geotechnical centrifuge experiments. The coupled Eulerian–Lagrangian (CEL) approach is used to accommodate the large deformations of a spudcan footing penetrating sand overlying clay. Modified Mohr–Coulomb and Tresca models describe the sand and clay behaviour, with modifications accounting for the effects of strain softening on the response of the soil. The CEL results are shown to match centrifuge tests well, allowing the numerical study to be extended parametrically, and with confidence, to cover the range of layer geometries, sand relative densities and footing shapes that are of practical interest to offshore jack-ups. The results are used to (a) assess the performance of an existing model to predict the peak resistance in the sand layer (extending its range of application to medium dense to dense sands and to conical footings of angle 0° to 21°), and (b) develop an expression for the bearing capacity factor when the footing penetrates into the underlying clay. Using the analytical formulas proposed, retrospective simulations of centrifuge tests show that the method provides a reasonable estimate of the peak punch-through load, the behaviour in the underlying clay, as well as the punch-through distance; the latter being a basic reflection of the severity of a potential punch-through failure.

Integral bridges are a class of bridges with integral or semi-integral abutments, designed without expansion joints in the bridge deck of the superstructure. The significance of an integral bridge design is that it avoids durability and recurring maintenance issues with bridge joints, and maybe bearings, which are prevalent in traditional bridges. Integral bridges are less costly to construct. They require less maintenance and therefore cause less traffic disruptions that incur socio-economic costs. As a consequence, integral bridges are becoming the first choice of bridge design for short-to-medium length bridges in many countries, including the UK, USA, Europe, Australia, New Zealand and many other Asian countries. However, integral bridge designs are not without challenges: issues that concern concrete creep, shrinkage, temperature effects, bridge skew, structural constraints, as well as soil–structure interactions are amplified in integral bridges. The increased cyclic soil–structure interactions between the bridge structure and soil will lead to adverse soil ratcheting and settlement bump at the bridge approach. If movements from bridge superstructures were also transferred to pile-supported substructures, there is a risk that the pile–soil interactions may lead to pile fatigue failure. These issues complicate the geotechnical aspects of integral bridges. The aim of this paper is to present a comprehensive review of current geotechnical design practices and the amelioration of soil–structure interactions of integral bridges.

Central nervous system (CNS) disorders, such as ischemic stroke, neurodegenerative diseases, multiple sclerosis, traumatic brain injury, and corresponding neuropathological changes, often lead to death or long-term disability. Long non-coding RNA (lncRNA) is a class of non-coding RNA with a transcription length over 200 nt and transcriptional regulation. lncRNA is extensively involved in physiological and pathological processes through epigenetic, transcription, and post-transcriptional regulation. Further, dysregulated lncRNA is closely related to the occurrence and development of human diseases, including CNS disorders. HOX Transcript antisense RNA (HOTAIR) is the first discovered lncRNA with trans-transcriptional regulation. Recent studies have shown that HOTAIR may participate in the regulation of the occurrence and development of CNS disorders. In addition, HOTAIR has the potential to become a new biomarker for the diagnosis and prognosis assessment of CNS disorders and even provide a new therapeutic target for CNS disorders. Here, we reviewed the research results of HOTAIR in CNS disorders to provide new insights into the pathogenesis, diagnostic value, and therapeutic target potential of HOTAIR in human CNS disorders.

This paper reports on a series of centrifuge model tests investigating the effect of shape on the penetration resistance of spudcan and conical footings on sand overlying clay. The effect of footing shape and geometry on single-layer soil has been studied intensely. However, there is still limited understanding for conical footings on sand over clay. In the present study, digital images were captured during penetration of various shapes of half-footing held against a transparent window of a strongbox. The images were then analysed using particle image velocimetry techniques. Experimental evidence has shown that, irrespective of the conical angle of the underside within the range of 7–21°, when the footing penetrates through sand into an underlying clay layer: (a) accumulated radial and deviatoric shear strains along the future failure surface counteract each other, resulting in similar peak resistance in the sand layer and (b) a trapped sand plug of constant height is pushed into the underlying clay layer. These observations serve to justify the previously proposed methods for predicting the full penetration resistance profile on sand overlying clay, which is required to predict the potential for, and severity of, punch-through failure.