Citrus is one of the main fruit crops cultivated in tropical and subtropical regions worldwide. Approximately half (40–47%) of the fruit mass is inedible and discarded as waste after processing, which causes pollution to the environment. Essential oils (EOs) are aromatic compounds found in significant quantities in oil sacs or oil glands present in the leaves, flowers, and fruit peels (mainly the flavedo part). Citrus EO is a complex mixture of ~400 compounds and has been found to be useful in aromatic infusions for personal health care, perfumes, pharmaceuticals, color enhancers in foods and beverages, and aromatherapy. The citrus EOs possess a pleasant scent, and impart relaxing, calming, mood-uplifting, and cheer-enhancing effects. In aromatherapy, it is applied either in message oils or in diffusion sprays for homes and vehicle sittings. The diffusion creates a fresh feeling and enhances relaxation from stress and anxiety and helps uplifting mood and boosting emotional and physical energy. This review presents a comprehensive outlook on the composition, properties, characterization, and mechanism of action of the citrus EOs in various health-related issues, with a focus on its antioxidant properties.

Oxidative stress, a pivotal driver of neurodegenerative diseases, results from an imbalance between the generation of reactive oxygen species (ROS) and cellular antioxidant defenses. This review provides a comprehensive analysis of key oxidative stress sources, focusing on NADPH oxidase (NOX) hyperactivity and mitochondrial Uncoupling Protein (UCP) downregulation. Critically, we examine the therapeutic potential of phytochemicals in mitigating NOX-mediated ROS generation through direct enzyme inhibition, including impacts on NOX subunit assembly and gene expression. Furthermore, we explore the ability of phytochemicals to bolster cellular antioxidant defenses by activating the Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway, elucidating the upregulation of antioxidant genes, such as GPx, SOD, CAT, and HO-1. This review expands beyond confined overviews; emphasizes specific molecular interactions between phytochemicals and target proteins, including NOX isoforms; and provides an in-depth analysis of the specific antioxidant genes upregulated via Nrf2. This approach aims to pave the way for targeted and translatable therapeutic strategies in neurodegenerative diseases. Ultimately, this review illuminates the intricate molecular dynamics of oxidative stress in neurodegenerative diseases; underscores the potential of phytochemicals to restore redox homeostasis and reverse pathological conditions through precise modulation of key signaling pathways.

Background: Cutaneous leishmaniasis (CL) is an ulcerative skin disease caused by some species of the genusLeishmania. Evidence shows thatPerovskia abrotanoidesis an important herbal medicine againstLeishmania.This study was conducted to investigate the killing effect of terpenoid-rich fractions on promastigotes ofL. major(MRHO/IR/75/ER).Material and Method: The eluates of reverse phased medium pressure liquid chromatography (RP-MPLC) of the extract were subjected to thin-layer chromatography (TLC) and categorized into six final fractions. Primary proton nuclear magnetic resonance (H-NMR) spectroscopy confirmed fractions' nature. Fractions 4, 5, and 6 (F4, F5, F6) were identified as terpenoid-rich content. Two concentrations of 50 and 100 μg/ml were prepared to test leishmanicidal activity. Followed by treating promastigotes ofL. majorby the fractions in incubation times of 12, 24, and 48 hours, their viability was determined using a cell proliferation MTS ((3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay.Result: F4, F5, and F6 showed significant killing activity on promastigotes ofL. majorin a concentration-dependent manner. The viability of promastigotes was significantly reduced at a concentration of 100 μg/ml compared to 50 μg/ml (P-value <0.05). Also, over time a significant decreasing trend in the viability of promastigotes confirmed the time-dependent manner of the fractions (P-value <0.01). Furthermore, F5 had the highest leishmanicidal activity at the first incubation time compared with other fractions.Conclusion: Terpenoid-rich fractions of theP. abrotanoideshave a leishmanicidal activity that depends on time and concentration. Among them, F5 has the highest potency that may contain potent terpenoid constituents.

Air pollution is a public health threat that requires urgent action. This study conducted a bibliometric analysis of air pollution and human health in Indian cities to examine trends and the geography of the scientific literature, the evolution of research, and co-occurrence patterns of pollution sources, types, and health impacts. Furthermore, a narrative review of air pollution mitigation strategies was conducted using scholarly articles, policy documents, and reports. Relevant publications from the Web of Science (WoS) and Scopus databases were downloaded. The search identified 3307 articles published between 1987 and 2024, of which 172 met the inclusion criteria. The bibliometric analysis was conducted using VOSviewer and R software. The results indicate a steady rise in studies on air pollution and health issues in India. Initially, research concentrated on various sources and types of pollution, subsequently transitioning to the evaluation of exposure risks, risk assessment, and health implications, ultimately narrowing its focus to risk assessment concerning human health. Over the course of forty years, there has been a growing emphasis on the influence of indoor air quality, including ‘PM2.5’, ‘PM10’, dust, chemical pollutants, heavy metals, and exhaust dust, on human health. Research on pollution-related health effects has moved from examining general impacts to focusing on long-term, chronic consequences of pollutant exposure. Notably, most studies are centred in large metropolitan areas, whereas medium and small towns are underrepresented. Urban areas face severe air-quality challenges, requiring strategies such as monitoring pollution, promoting renewable energy, reusing materials, installing green walls or buffers in pollution zones, improving transport infrastructure, and reducing dust with grass covers. This study underscores the importance of implementing effective air pollution control measures across various geographic regions and integrating air pollution mitigation strategies into comprehensive urban development and planning frameworks.