In tissue engineering, a highly porous artificial extracellular matrix or scaffold is required to accommodate mammalian cells and guide their growth and tissue regeneration in three dimensions. However, existing three-dimensional scaffolds for tissue engineering proved less than ideal for actual applications, not only because they lack mechanical strength, but they also do not guarantee interconnected channels. In this paper, the authors analyze the factors necessary to enhance the design and manufacture of scaffolds for use in tissue engineering in terms of materials, structure, and mechanical properties and review the traditional scaffold fabrication methods. Advantages and limitations of these traditional methods are also discussed.

Additive manufacturing (AM), commonly known as three-dimensional (3D) printing or rapid prototyping, has been introduced since the late 1980s. Although a considerable amount of progress has been made in this field, there is still a lot of research work to be done in order to overcome the various challenges remained. Recently, one of the actively researched areas lies in the additive manufacturing of smart materials and structures. Smart materials are those materials that have the ability to change their shape or properties under the influence of external stimuli. With the introduction of smart materials, the AM-fabricated components are able to alter their shape or properties over time (the 4th dimension) as a response to the applied external stimuli. Hence, this gives rise to a new term called ‘4D printing’ to include the structural reconfiguration over time. In this paper, recent major progresses in 4D printing are reviewed, including 3D printing of enhanced smart nanocomposites, shape memory alloys, shape memory polymers, actuators for soft robotics, self-evolving structures, anti-counterfeiting system, active origami and controlled sequential folding, and some results from our ongoing research. In addition, some research activities on 4D bio-printing are included, followed by discussions on the challenges, applications, research directions and future trends of 4D printing.

Three-dimensional (3D) printing (also known as additive manufacturing) is an advanced manufacturing process that can produce complex shape geometries automatically from a 3D computer-aided design model without any tooling, dies and fixtures. This automated manufacturing process has been applied to many diverse fields of industries today due to significant advantages of creating functional prototypes in reasonable build time with less human intervention and minimum material wastage. However, a more recent application of this technology towards the built environment seems to improve our traditional building strategies while reducing the need for human resources, high capital investments and additional formworks. Research interest in employing 3D printing for building and construction has increased exponentially in the past few years. This paper reviews the latest research trends in the discipline by analysing publications from 1997 to 2016. Some recent developments for 3D concrete printing at the Singapore Centre for 3D Printing are also discussed here. Finally, this paper gives a brief description of future work that can be done to improve both the capability and printing quality of the current systems.